L'âge est-il un facteur de risque pour les anomalies des 5' UTR ?
Oui, l'âge avancé peut augmenter le risque de mutations dans les 5' UTR et d'autres gènes.
ÂgeMutations
#3
Les habitudes alimentaires influencent-elles les 5' UTR ?
Certaines habitudes alimentaires peuvent affecter l'expression des gènes, y compris les 5' UTR.
Habitudes alimentairesExpression des gènes
#4
Le stress peut-il affecter les 5' UTR ?
Oui, le stress peut influencer l'expression génique et potentiellement affecter les 5' UTR.
StressExpression génique
#5
Les infections virales sont-elles un facteur de risque pour les anomalies des 5' UTR ?
Certaines infections virales peuvent induire des modifications dans les 5' UTR, augmentant les risques.
Infections viralesModifications génétiques
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"name": "Les vaccinations influencent-elles les 5' UTR ?",
"position": 15,
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"name": "Comment les traitements ciblent-ils les 5' UTR ?",
"position": 16,
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"text": "Des thérapies géniques et des oligonucléotides peuvent cibler les 5' UTR pour moduler l'expression."
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"@type": "Question",
"name": "Les médicaments peuvent-ils interagir avec les 5' UTR ?",
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"text": "Oui, certains médicaments peuvent moduler l'activité des 5' UTR, influençant la traduction."
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"@type": "Question",
"name": "Y a-t-il des traitements pour corriger les anomalies des 5' UTR ?",
"position": 18,
"acceptedAnswer": {
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"text": "Des approches de thérapie génique sont en développement pour corriger ces anomalies."
}
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"name": "Les traitements ciblant les 5' UTR sont-ils efficaces ?",
"position": 19,
"acceptedAnswer": {
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"text": "L'efficacité dépend du type de mutation et du contexte biologique de la maladie."
}
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"@type": "Question",
"name": "Les 5' UTR influencent-elles la résistance aux traitements ?",
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"name": "Quelles complications peuvent survenir avec des anomalies des 5' UTR ?",
"position": 21,
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"position": 22,
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}
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"position": 23,
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}
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"name": "Les complications liées aux 5' UTR sont-elles réversibles ?",
"position": 24,
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}
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"name": "Les 5' UTR sont-elles impliquées dans des complications post-thérapeutiques ?",
"position": 25,
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}
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"name": "Quels sont les facteurs de risque pour les anomalies des 5' UTR ?",
"position": 26,
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}
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}
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"@type": "Question",
"name": "Les habitudes alimentaires influencent-elles les 5' UTR ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines habitudes alimentaires peuvent affecter l'expression des gènes, y compris les 5' UTR."
}
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"name": "Le stress peut-il affecter les 5' UTR ?",
"position": 29,
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"name": "Les infections virales sont-elles un facteur de risque pour les anomalies des 5' UTR ?",
"position": 30,
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State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P.R. China.
State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P.R. China.
State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P.R. China.
State Key Laboratory for Animal Disease Control and Prevention, College of Veterinary Medicine, Lanzhou University, Lanzhou Veterinary Research Institute, Chinese Academy of Agricultural Sciences, Lanzhou, P.R. China.
Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA.
Molecular and Cellular Biology, University of Washington, Seattle, WA 98195, USA; Division of Human Biology, Fred Hutchinson Cancer Research Center, Seattle, WA, 98109, USA; School of Medicine and Genome Sciences, University of Washington, Seattle, WA 98195, USA. Electronic address: ahsieh@fredhutch.org.
Borderline personality disorder (BPD) is a complex condition marked by heterogeneity. People with BPD have a profusion of symptoms spread across various levels of lived experience, such as identity, a...
Low personal agency is the concept of attributing successes and failures to external factors rather than personal characteristics. Previous research supported links between low personal agency and sym...
Patients (N = 57, age 18-72, 91.5% female) were assessed at intake, after three months of DBT treatment, and 12 months follow up on measures of symptoms and personal agency. Three separate measures we...
Mixed model analyses found BPD symptoms significantly reduced as a result of DBT treatment and were maintained at follow-up. However, 47% of participants continued to meet BPD criteria 12 months later...
Despite the reductions in BPD symptomology, personal agency did not significantly change over time. Those with lower agency at intake continued to do more poorly at follow up. We speculate that poor o...
The goal of this study was to evaluate specific characteristics associated with hopelessness, potentially correlated with coping strategies, sensory profile, and alexithymia in patients with borderlin...
Two hundred twenty-four (N=224) inpatients completed a clinical interview with administration of the Beck Hopelessness Scale (BHS), the Adolescent/Adult Sensory Profile (AASP), the Coping Orientation ...
Hopelessness was significantly associated with female gender, more hospitalizations, current suicidal ideation, number of suicide attempts, current and lifetime medication abuse, and alcohol misuse. F...
Hopelessness in BPD was associated with higher severity of illness, alternative process sensory input from the environment, reduced ability to cope with stressful events, and alexithymia. Therefore, a...
Among people with a diagnosis of borderline personality disorder (BPD) who are engaged in clinical care, prescription rates of psychotropic medications are high, despite the fact that medication use i...
To assess the effects of pharmacological treatment for people with BPD....
For this update, we searched CENTRAL, MEDLINE, Embase, 14 other databases and four trials registers up to February 2022. We contacted researchers working in the field to ask for additional data from p...
Randomised controlled trials comparing pharmacological treatment to placebo, other pharmacologic treatments or a combination of pharmacologic treatments in people of all ages with a formal diagnosis o...
At least two review authors independently selected trials, extracted data, assessed risk of bias using Cochrane's risk of bias tool and assessed the certainty of the evidence using the GRADE approach....
We included 46 randomised controlled trials (2769 participants) in this review, 45 of which were eligible for quantitative analysis and comprised 2752 participants with BPD in total. This is 18 more t...
This review included 18 more trials than the 2010 version, so larger meta-analyses with more statistical power were feasible. We found mostly very low-certainty evidence that medication may result in ...
People diagnosed with borderline personality disorder (BPD) frequently present to healthcare services in crisis, often with suicidal thoughts or actions. Despite this, little is known about what const...
To assess the effects of crisis interventions in adults diagnosed with BPD in any setting....
We searched CENTRAL, MEDLINE, Embase, nine other databases and three trials registers up to January 2022. We also checked reference lists, handsearched relevant journal archives and contacted experts ...
Randomised controlled trials (RCTs) comparing crisis interventions with usual care, no intervention or waiting list, in adults of any age diagnosed with BPD....
We used standard methodological procedures expected by Cochrane....
We included two studies with 213 participants. One study (88 participants) was a feasibility RCT conducted in the UK that examined the effects of joint crisis plans (JCPs) plus treatment as usual (TAU...
A comprehensive search of the literature revealed very little RCT-based evidence to inform the management of acute crises in people diagnosed with BPD. We included two studies of two very different ty...
The progressively improving understanding of the borderline personality disorder (BPD) has led to an increased interest in the better clarification of the integrated role of biological and psychosocia...
Previous research has emphasized the importance of therapists giving Routine Outcome Monitoring (ROM) feedback to their patients. It has been shown that several factors influence therapists' tendency ...
In this qualitative study, using a semi-structured interview followed by thematic analysis using Atlas.ti, we focused on experiences of therapists and patients with a disorder specific ROM instrument:...
Qualitative analysis revealed that patients experienced benefits of ROM using the BPDSI-IV. Patients gained more insight in and recognition of their borderline personality disorder symptoms. They also...
Experiences of both patients and therapists with the BPDSI-IV were positive. It seems to be valuable and promising for healthcare institutions to evaluate treatment with a disorder specific ROM instru...
It has been suggested that the diagnosis of borderline personality disorder (BPD) is associated with particularly stigmatizing connotations, particularly among mental health professionals. The goal of...
A systematic search was carried out using MEDLINE Complete, CINAHL Complete, PsychoINFO, PsychARTICLES, Scopus, Social Sciences Citation Index, and Academic Search Complete. Study quality was rated us...
This review included 37 papers involving an estimated 8196 participants: 21 cross-sectional survey studies, 5 studies assessing training workshops, 5 studies assessing countertransference, and 6 exper...
Negative attitudes toward BPD continue to be a problem to differing degrees among clinical staff. Although this issue is most prominent among psychiatric nurses, the results of this review highlight e...
Comorbidity between borderline personality disorder (BPD) and other mental disorders is common. Although no specific pharmacological treatments have been approved for the treatment of BPD, many drugs,...
Borderline Personality Disorder (BPD) is often perceived to be a female-predominant disorder in both research and clinical contexts. Although there is growing recognition of possible sex differences, ...
