questionsmedicales.fr
Maladies du système immunitaire
Troubles de l'activation mastocytaire
Mastocytose
Mastocytose cutanée
Mastocytose cutanée : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Mastocytose
Biopsie cutanée
Urticaire
Affections cutanées
Antécédents médicaux
Allergies
Symptômes
5
Démangeaisons
Lésions cutanées
Variabilité des symptômes
Individus
Symptômes systémiques
Nausées
Lésions cutanées
Contagiosité
Prévention
5
Stress
Poussées de symptômes
Soins de la peau
Irritations
Traitements
5
Antihistaminiques
Corticostéroïdes
Antihistaminiques
Démangeaisons
Photothérapie
Lésions cutanées
Gestion des symptômes
Traitements
Traitements alternatifs
Efficacité
Complications
5
Complications
Infections cutanées
Mastocytose systémique
Évolution
Gestion
Consultation spécialisée
Facteurs de risque
5
Facteurs de risque
Antécédents familiaux
Maladies auto-immunes
Risque
Produits chimiques
Exposition
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"@type": "Question",
"name": "Comment diagnostique-t-on la mastocytose cutanée ?",
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"text": "Le diagnostic repose sur l'examen clinique et la biopsie cutanée pour détecter les mastocytes."
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},
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"@type": "Question",
"name": "Quels tests sont utilisés pour confirmer la mastocytose ?",
"position": 2,
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"name": "Les symptômes sont-ils suffisants pour le diagnostic ?",
"position": 3,
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"name": "La mastocytose cutanée est-elle confondue avec d'autres maladies ?",
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"text": "Oui, elle peut être confondue avec d'autres affections cutanées comme l'urticaire."
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"@type": "Question",
"name": "Quels sont les symptômes courants de la mastocytose cutanée ?",
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"@type": "Question",
"name": "La mastocytose cutanée provoque-t-elle des douleurs ?",
"position": 7,
"acceptedAnswer": {
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"text": "Elle peut provoquer des douleurs localisées, surtout en cas de lésions étendues."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils d'une personne à l'autre ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'intensité et la nature des symptômes peuvent varier considérablement."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes systémiques associés ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes systémiques comme des nausées peuvent survenir dans certains cas."
}
},
{
"@type": "Question",
"name": "Les lésions cutanées sont-elles contagieuses ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, les lésions cutanées de la mastocytose ne sont pas contagieuses."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir la mastocytose cutanée ?",
"position": 11,
"acceptedAnswer": {
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"text": "Il n'existe pas de méthode de prévention spécifique pour la mastocytose cutanée."
}
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{
"@type": "Question",
"name": "Les allergènes peuvent-ils aggraver la condition ?",
"position": 12,
"acceptedAnswer": {
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"text": "Oui, l'exposition à certains allergènes peut aggraver les symptômes."
}
},
{
"@type": "Question",
"name": "Faut-il éviter certains médicaments ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments peuvent déclencher des réactions chez les patients sensibles."
}
},
{
"@type": "Question",
"name": "L'évitement du stress aide-t-il ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Gérer le stress peut aider à réduire les poussées de symptômes chez certains patients."
}
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{
"@type": "Question",
"name": "Les soins de la peau sont-ils importants ?",
"position": 15,
"acceptedAnswer": {
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"text": "Oui, des soins appropriés de la peau peuvent aider à minimiser les irritations."
}
},
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"@type": "Question",
"name": "Quels traitements sont disponibles pour la mastocytose cutanée ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des antihistaminiques et des corticostéroïdes topiques."
}
},
{
"@type": "Question",
"name": "Les antihistaminiques sont-ils efficaces ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils aident à réduire les démangeaisons et les rougeurs."
}
},
{
"@type": "Question",
"name": "La photothérapie est-elle une option de traitement ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la photothérapie peut être utilisée pour traiter les lésions cutanées."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils permanents ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, les traitements visent à gérer les symptômes, pas à guérir la maladie."
}
},
{
"@type": "Question",
"name": "Des traitements alternatifs existent-ils ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines personnes explorent des traitements alternatifs, mais leur efficacité n'est pas prouvée."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec la mastocytose cutanée ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme des infections cutanées peuvent survenir en raison de lésions."
}
},
{
"@type": "Question",
"name": "La mastocytose cutanée peut-elle évoluer vers une forme plus grave ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Dans de rares cas, elle peut évoluer vers une mastocytose systémique."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles fréquentes ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications ne sont pas fréquentes mais peuvent survenir chez certains patients."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion des complications nécessite souvent une consultation spécialisée."
}
},
{
"@type": "Question",
"name": "Les complications affectent-elles la qualité de vie ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les complications peuvent affecter la qualité de vie en raison de l'inconfort."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque de la mastocytose cutanée ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents familiaux et des allergies cutanées."
}
},
{
"@type": "Question",
"name": "L'âge joue-t-il un rôle dans la mastocytose cutanée ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la mastocytose cutanée est plus fréquente chez les enfants et les jeunes adultes."
}
},
{
"@type": "Question",
"name": "Les femmes sont-elles plus touchées que les hommes ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, la mastocytose cutanée affecte les hommes et les femmes de manière égale."
}
},
{
"@type": "Question",
"name": "Les maladies auto-immunes augmentent-elles le risque ?",
"position": 29,
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"text": "Oui, certaines maladies auto-immunes peuvent augmenter le risque de mastocytose."
}
},
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"@type": "Question",
"name": "L'exposition à des produits chimiques est-elle un facteur ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certains produits chimiques peut être un facteur de risque."
}
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}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 01/05/2025
Contenu vérifié selon les dernières recommandations médicales
9 publications dans cette catégorie
Affiliations :
Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, 80-211 Gdańsk, Poland.
6 publications dans cette catégorie
Affiliations :
Allergologische Poliklinik, Klinik für Dermatologie, Universitätsspital Basel, Petersgraben 4, 4031, Basel, Schweiz. karin.hartmann@usb.ch.
5 publications dans cette catégorie
Affiliations :
Department of Dermatology and Allergy Biederstein, School of Medicine and Health, Technical University of Munich, 80802 Munich, Germany.
Department of Dermatology and Allergy Centre, Odense University Hospital, 5000 Odense, Denmark.
Publications dans "Mastocytose cutanée" :
5 publications dans cette catégorie
Affiliations :
Department of Dermatology, Venereology and Allergology, Medical University of Gdańsk, 80-211 Gdańsk, Poland.
Publications dans "Mastocytose cutanée" :
5 publications dans cette catégorie
Affiliations :
Department of Hematology and Mastocytosis Expert Centre (CEREMAST), Necker Children's Hospital and Paris Descartes University, Assistance Publique Hôpitaux de Paris, Paris, France. Electronic address: ohermine@gmail.com.
Publications dans "Mastocytose cutanée" :
5 publications dans cette catégorie
Affiliations :
Department of Hematology Oncology, Fondazione IRCCS Policlinico San Matteo, University of Pavia, Pavia, Italy.
Publications dans "Mastocytose cutanée" :
5 publications dans cette catégorie
Affiliations :
Department of Allergology, Medical University of Gdansk, Gdansk, Poland.
Publications dans "Mastocytose cutanée" :
5 publications dans cette catégorie
Affiliations :
Section of Hematology, Department of Medicine, Verona University Hospital, Verona, Italy.
Publications dans "Mastocytose cutanée" :
5 publications dans cette catégorie
Affiliations :
Allergy Unit, Verona University Hospital, Verona, Italy.
Publications dans "Mastocytose cutanée" :
5 publications dans cette catégorie
Affiliations :
Division of Hematology, Department of Medicine, Stanford University School of Medicine, Stanford, California, USA.
Publications dans "Mastocytose cutanée" :
5 publications dans cette catégorie
Affiliations :
Department of Hematology and Oncology, University Hospital Mannheim, Heidelberg University, Mannheim, Germany.
Publications dans "Mastocytose cutanée" :
4 publications dans cette catégorie
Affiliations :
Department of Internal Medicine I, Division of Hematology & Hemostaseology, Medical University of Vienna, Vienna, Austria; Ludwig Boltzmann Institute for Hematology and Oncology, Medical University of Vienna, Vienna, Austria; Internal Medicine Small Animals, University Clinic for Small Animals, Department/University Clinic for Companion Animals and Horses, University of Veterinary Medicine, Vienna, Austria.
Publications dans "Mastocytose cutanée" :
4 publications dans cette catégorie
Affiliations :
Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy.
Publications dans "Mastocytose cutanée" :
4 publications dans cette catégorie
Affiliations :
Pediatric Dermatology Unit, Department of Medicine, University of Padova, Padova, Italy.
Publications dans "Mastocytose cutanée" :
4 publications dans cette catégorie
Affiliations :
Pediatric Dermatology Unit, Department of Medicine, University of Padova, Padova, Italy.
Publications dans "Mastocytose cutanée" :
4 publications dans cette catégorie
Affiliations :
University Hospital and Faculty of Medicine, Brno, Czechia.
Publications dans "Mastocytose cutanée" :
4 publications dans cette catégorie
Affiliations :
Faculty of Medicine and Health Sciences, Department of Immunology-Allergology-Rheumatology, University of Antwerp and Antwerp University Hospital, Antwerpen, Belgium.
Publications dans "Mastocytose cutanée" :
4 publications dans cette catégorie
Affiliations :
Division of Allergy and Clinical Immunology, University of Salerno, Salerno, Italy.
Publications dans "Mastocytose cutanée" :
4 publications dans cette catégorie
Affiliations :
Department of Hematology, University Medical Center Groningen, University of Groningen, Groningen, The Netherlands.
Publications dans "Mastocytose cutanée" :
4 publications dans cette catégorie
Affiliations :
Department of Oncology, Haematology, Haemostaseology and Stem Cell Transplantation, University Hospital RWTH Aachen, Aachen, Germany; Center for Integrated Oncology, Aachen Bonn Cologne Düsseldorf (CIO ABCD), Aachen, Germany.
Publications dans "Mastocytose cutanée" :
Osteoarthritis (OA) affects more than 500 million people worldwide and is among the five diseases in Germany causing the highest suffering of the patients and cost for the society. The quality of life...
Neuromyelitis Optica Spectrum Disorders (NMOSD) is an antibody-mediated disorder of the Central Nervous System where a leading role of the complement system has been demonstrated....
To measure the levels of complement factors C3, C4 and C5a in serum and plasma of clinical remission patients with AQP4-IgG + NMOSD....
Twelve patients with NMOSD AQP4 + according to 2015 criteria from a General Hospital in Buenos Aires, Argentina, were included in the study, and 19 age- and sex-matched healthy volunteers as a control...
The complement factors, C3, C4, and C5a were measured in all samples. The mean concentration of C3 was 130.7 mg/dl (SD 16.1 mg/dl), and the mean concentration of C4 was 21.6 mg/dl (SD 4.8 mg/dl); both...
In conclusion, the present study demonstrates that plasma C5a may be interesting to investigate as a potential biomarker of disease activity in NMOSD, in a larger and prospective cohort....
Diabetic kidney disease (DKD) affects 30-40% of patients with diabetes and is currently the leading cause of end-stage renal disease (ESRD). The activation of the complement cascade, a highly conserve...
Complement C5a is an important component of the innate immune system. An increasing number of reports have revealed the relevance of C5a in tumor progression; however, its exact role in metastatic ren...
We evaluated C5a expression in tumor tissue microarrays of 231 mRCC patients and analyzed the relationship between C5a levels and clinical outcomes, and the expression of epithelial-mesenchymal transi...
High C5a expression was associated with poor therapeutic responses, poor overall and progression-free survival, and high expression of EMT-related proteins and PD-1/PD-L1 in mRCC patients. Exogenous C...
Our findings indicate that elevated C5a expression is associated with poor outcomes in patients with mRCC, and this effect may be partly attributed to the ability of C5a to promote EMT and PD-1/PD-L1 ...
The clinical efficacy and safety of complement C5a inhibitors for patients with severe COVID-19 remains unclear....
The PubMed, Embase, Cochrane Library, and ClinicalTrials.gov databases were searched from their inception to 27 September 2022. Only studies that assessed the usefulness of C5a inhibitors for the trea...
Six studies, including four randomized controlled trials (RCTs) and two non-RCTs, were included. The study group receiving C5a inhibitors had a significantly lower risk of mortality compared with the ...
C5a inhibitors could help reduce the risk of mortality in patients with severe COVID-19 infection while being as safe as placebos. These findings support the promising role of C5a inhibitors in the tr...
Involvement of lower gastrointestinal tract (LGI) occurs in 60% of patients with graft-versus-host-disease (GVHD). Complement components C3 and C5 are involved in GVHD pathogenesis. In this phase 2a s...
Numerous publications have underlined the link between complement C5a and the clinical course of COVID-19. We previously reported that levels of C5a remain high in the group of severely ill patients u...
To examine concentrations of circulating antibodies targeting C3a and C5a complement receptors in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) and analyze their associati...
Concentrations of antibodies against C3a and C5a complement receptors (anti-C3aR and anti-C5aR) and plasma complement fragments C3a and C5a were determined in patients with AAV (n = 110; granulomatosi...
In AAV, anti-C3aR and anti-C5aR antibodies were decreased (P = 0.0026 and P ≤ 0.0001, respectively). In remission, anti-C3aR antibody concentrations rose to values comparable to healthy donors, wherea...
Low concentrations of anti-C5aR antibodies reflect disease activity and are associated with an increased risk for relapse in AAV....
A complement effect on homeostasis during infection is determined by both cytotoxic (activate complement component 5 (C5a) terminal cytotoxic complex (TCC)), and cytoprotective elements (complement fa...
The conjunctiva has immune-responsive properties to protect the eye from infections. Its innate immune system reacts against external pathogens, such as fungi. The complement factor C5a is an importan...