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"description": "Comment diagnostiquer une déficience en 16-alpha-hydroxylase ?\nQuels tests génétiques sont utilisés pour cette enzyme ?\nQuels symptômes peuvent indiquer un problème avec cette enzyme ?\nQuel rôle joue l'imagerie dans le diagnostic ?\nLes tests de fonction hépatique sont-ils pertinents ?",
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"description": "Quelles complications peuvent survenir avec un déséquilibre hormonal ?\nLes troubles psychologiques sont-ils liés à cette enzyme ?\nY a-t-il des risques de cancer associés ?\nComment les maladies métaboliques sont-elles liées ?\nLes complications sont-elles réversibles ?",
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"description": "Quels facteurs de risque sont associés à des troubles hormonaux ?\nL'âge influence-t-il le risque de déséquilibre hormonal ?\nLes médicaments peuvent-ils affecter cette enzyme ?\nLe mode de vie joue-t-il un rôle dans le risque ?\nLes facteurs environnementaux influencent-ils le risque ?",
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"@type": "Question",
"name": "Comment diagnostiquer une déficience en 16-alpha-hydroxylase ?",
"position": 1,
"acceptedAnswer": {
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"text": "Des tests sanguins pour mesurer les niveaux d'hormones stéroïdiennes sont effectués."
}
},
{
"@type": "Question",
"name": "Quels tests génétiques sont utilisés pour cette enzyme ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des analyses génétiques ciblent les mutations dans le gène CYP3A4."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec cette enzyme ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme l'hyperandrogénie ou des irrégularités menstruelles peuvent survenir."
}
},
{
"@type": "Question",
"name": "Quel rôle joue l'imagerie dans le diagnostic ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'imagerie peut aider à évaluer les glandes endocrines, mais n'est pas spécifique."
}
},
{
"@type": "Question",
"name": "Les tests de fonction hépatique sont-ils pertinents ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, car le foie est crucial pour le métabolisme des stéroïdes et peut indiquer des anomalies."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes d'une surproduction d'androgènes ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Acné, hirsutisme, irrégularités menstruelles et infertilité peuvent se manifester."
}
},
{
"@type": "Question",
"name": "Comment se manifeste une insuffisance en stéroïdes ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Fatigue, perte de poids, hypotension et dépression peuvent être des signes d'insuffisance."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon le sexe ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les hommes et les femmes peuvent présenter des symptômes différents en raison des hormones."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes associés à des troubles métaboliques ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles comme le diabète peuvent être liés à des anomalies hormonales."
}
},
{
"@type": "Question",
"name": "Les symptômes peuvent-ils apparaître à l'adolescence ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des changements hormonaux peuvent se manifester durant la puberté."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les troubles liés à cette enzyme ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une surveillance régulière et un mode de vie sain peuvent aider à prévenir certains troubles."
}
},
{
"@type": "Question",
"name": "Y a-t-il des tests de dépistage recommandés ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests hormonaux réguliers peuvent être recommandés pour les personnes à risque."
}
},
{
"@type": "Question",
"name": "Comment l'éducation peut-elle aider à la prévention ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'éducation sur les symptômes et les risques peut aider à une détection précoce."
}
},
{
"@type": "Question",
"name": "Les habitudes alimentaires influencent-elles la santé hormonale ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation équilibrée peut soutenir la santé hormonale et prévenir des déséquilibres."
}
},
{
"@type": "Question",
"name": "Le stress a-t-il un impact sur cette enzyme ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress peut affecter la production hormonale et aggraver les symptômes."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour les déséquilibres hormonaux ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies hormonales substitutives peuvent être prescrites pour rétablir l'équilibre."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils aider à réguler cette enzyme ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains inhibiteurs enzymatiques peuvent être utilisés pour moduler l'activité."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements non médicamenteux ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des changements de mode de vie, comme l'alimentation et l'exercice, peuvent aider."
}
},
{
"@type": "Question",
"name": "Comment la chirurgie peut-elle être impliquée ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Dans certains cas, une intervention chirurgicale peut être nécessaire pour corriger des anomalies."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils différents pour les hommes et les femmes ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction des besoins hormonaux spécifiques."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec un déséquilibre hormonal ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme l'infertilité, le diabète et des maladies cardiovasculaires peuvent survenir."
}
},
{
"@type": "Question",
"name": "Les troubles psychologiques sont-ils liés à cette enzyme ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles comme l'anxiété et la dépression peuvent être exacerbés par des déséquilibres."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de cancer associés ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines études suggèrent un lien entre les déséquilibres hormonaux et le cancer hormonal."
}
},
{
"@type": "Question",
"name": "Comment les maladies métaboliques sont-elles liées ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les déséquilibres hormonaux peuvent contribuer à des maladies métaboliques comme le diabète."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles avec un traitement approprié et précoce."
}
},
{
"@type": "Question",
"name": "Quels facteurs de risque sont associés à des troubles hormonaux ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des antécédents familiaux, l'obésité et le stress sont des facteurs de risque connus."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque de déséquilibre hormonal ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque augmente avec l'âge, surtout pendant la ménopause chez les femmes."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils affecter cette enzyme ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments peuvent interférer avec l'activité de la stéroïde 16-alpha-hydroxylase."
}
},
{
"@type": "Question",
"name": "Le mode de vie joue-t-il un rôle dans le risque ?",
"position": 29,
"acceptedAnswer": {
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"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent le risque."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux influencent-ils le risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certains produits chimiques peut affecter la fonction hormonale."
}
}
]
}
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Chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) has a high prevalence of up to 15% and accounts for 90-95% of prostatitis diagnoses, and yet its etiopathogenesis and link to prostate cancer...
To detect and analyze the changes of microorganisms in expressed prostatic secretion (EPS) of patients with IIIB prostatitis before and after low-intensity pulsed ultrasound (LIPUS) treatment, and to ...
Prostatitis is a common urological condition that affects almost half of all men at some point in their life. The prostate gland has a dense nerve supply that contributes to the production of fluid to...
This study aims to investigate a possible relationship between chronic prostatitis (CP) and Peyronie's disease (PD) and to characterize the psychological profile of patients suffering from PD, with or...
We included 539 patients with PD, of which 200 were found to have underlying CP. As a comparator population, we selected 2201 patients without PD, referring to our tertiary care clinic. In this popula...
The overall prevalence of chronic prostatitis in PD patients was 37.1% compared to a prevalence of 17.4% in the non-PD control population (OR = 2.79 and p < 0.0001). The severity of CP symptom total s...
Chronic prostatitis (CP) and Peyronie's disease (PD) are frequently associated. Our results demonstrate the strong impact of chronic prostatitis on the mental status of PD patients. Anxiety and depres...
Bacterial prostatitis is a highly prevalent infection responsible for significant morbidity among men. The diagnosis and treatment for bacterial prostatitis remains complicated. The difficulty in diag...
We aimed to provide a useful resource for clinicians in effectively diagnosing and managing acute bacterial prostatitis (ABP) and chronic bacterial prostatitis (CBP)....
A PubMed literature search on prostatitis was performed with no restrictions on publication date....
The epidemiology, pathophysiology, diagnosis, and treatment for ABP and CBP are explored using a clinical vignette as relevant context....
Bacterial prostatitis can be diagnosed through a focused history and microbiological investigations. The Meares-Stamey 4-glass test or modified 2-glass test can help confirm the diagnosis if uncertain...
Bacterial prostatitis, acute or chronic, is one of the most prevalent urogenital infections in men. Its diagnosis requires the application of a careful methodology. Gram-negative bacilli are the most ...
The aim of this article is to summarize the current evidence regarding the pathogenesis, etiology, empirical and definitive antimicrobial therapy, and new pharmacotherapeutic interventions to improve ...
Bacterial prostatitis requires the application of an accurate diagnostic protocol to identify the causative agent and establish the optimal antimicrobial treatment. The structural and biochemical char...
To evaluate the relation between resistive index (RI) of prostatic capsular arteries by transrectal Doppler ultrasonography in chronic prostatitis/chronic pelvic pain syndrome (CP/CPPS) and its correl...
In total, we included 68 patients presenting with chronic prostatitis/chronic pelvic pain syndrome. We formed two groups, as Group 1 of 35 patients with a RI ≥ 0.7 and Group 2 of 33 patients with RI <...
Demographic characteristics were similar in the two groups. IPSS was 11.3 ± 6 in Group 1 and 9.7 ± 5.3 in Group 2. IIEF-5 was 18.6 ± 2 in Group 1 and 20.4 ± 2.3 in Group 2. PEDT was 12.4 ± 5.6 in Grou...
There is a significant correlation between the lower urinary tract symptoms and erectile dysfunction parameters and the RI of the prostatic capsular artery in CP/CPPS and RI is an effective and noninv...
Single-cell RNA sequencing studies in the human prostate have defined a population of epithelial cells with transcriptional similarities to club cells in the lung. However, the localization of club-li...
Benign prostate hyperplasia (BPH) is a common cause for bladder outlet obstruction (BOO) and lower urinary tract symptoms (LUTS) in men. The pathophysiology of BPH is multifactorial and inflammation h...
Patients who had undergone TURP for BPH at a single institution between 2014 and 2018 were included. The study population was divided into three cohorts: those with no histological inflammation, those...
A total 198 patients were included (no inflammation n = 101; any inflammation n = 97, prostatic stromal inflammation n = 81). All three groups were comparable in terms of baseline characteristics. The...
Histological prostatitis is associated with worse urinary outcomes after TURP compared to no inflammation. These results are useful in improving prognostic discussions with patients after TURP....
The expression of programmed cell death ligand protein (PD-L1) is weakly investigated in non-tumoral and inflammatory prostatic pathology. The diagnosis of granulomatous prostatitis (GP) rests on the ...
We studied PD-L1 expression in 17 GP cases (9 nonspecific GP, 5 Bacillus Calmette-Guérin induced prostatitis, 1 prostatic tuberculosis, and 3 cases of postsurgical prostatic granulomas). The control g...
All of the GP cases showed easily visible strong membranous PD-L1 expression (high levels of combined positive score) in localized and diffuse epithelioid granulomatous prostatic inflammation. None of...
The study presents the first attempt to examine PD-L1 expression in GP. Granulomatous inflammation in GP is easily identified when stained with PD-L1....