Titre : Kinases CDC2-CDC28

Kinases CDC2-CDC28 : Questions médicales fréquentes

Termes MeSH sélectionnés :

Scleroderma, Systemic
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validées par des experts médicaux.", "datePublished": "2025-05-18", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Kinases CDC2-CDC28", "description": "Comment diagnostiquer une dysfonction des kinases CDC2-CDC28 ?\nQuels tests sont utilisés pour évaluer l'activité des kinases CDC2-CDC28 ?\nLes biopsies peuvent-elles aider au diagnostic ?\nQuels marqueurs biologiques sont associés aux kinases CDC2-CDC28 ?\nLes tests génétiques sont-ils nécessaires pour le diagnostic ?", "url": "https://questionsmedicales.fr/mesh/D042846?mesh_terms=Scleroderma,+Systemic&page=2#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Kinases CDC2-CDC28", "description": "Quels symptômes indiquent une anomalie des kinases CDC2-CDC28 ?\nLes troubles de la division cellulaire sont-ils liés aux kinases CDC2-CDC28 ?\nPeut-on observer des anomalies morphologiques cellulaires ?\nLes cancers sont-ils liés aux dysfonctionnements des kinases CDC2-CDC28 ?\nY a-t-il des signes cliniques spécifiques à surveiller ?", "url": "https://questionsmedicales.fr/mesh/D042846?mesh_terms=Scleroderma,+Systemic&page=2#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Kinases CDC2-CDC28", "description": "Peut-on prévenir les dysfonctionnements des kinases CDC2-CDC28 ?\nY a-t-il des mesures préventives spécifiques ?\nL'alimentation joue-t-elle un rôle dans la prévention ?\nL'exercice physique peut-il aider à prévenir des anomalies ?\nLes vaccinations ont-elles un impact sur les kinases ?", "url": "https://questionsmedicales.fr/mesh/D042846?mesh_terms=Scleroderma,+Systemic&page=2#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Kinases CDC2-CDC28", "description": "Quels traitements ciblent les kinases CDC2-CDC28 ?\nLes thérapies géniques sont-elles une option ?\nComment les inhibiteurs de kinases sont-ils administrés ?\nY a-t-il des effets secondaires aux traitements ?\nLes traitements sont-ils personnalisés ?", "url": "https://questionsmedicales.fr/mesh/D042846?mesh_terms=Scleroderma,+Systemic&page=2#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Kinases CDC2-CDC28", "description": "Quelles complications peuvent survenir avec des anomalies des kinases ?\nLes anomalies des kinases peuvent-elles affecter d'autres systèmes ?\nY a-t-il des risques de résistance aux traitements ?\nLes complications sont-elles réversibles ?\nComment gérer les complications liées aux kinases ?", "url": "https://questionsmedicales.fr/mesh/D042846?mesh_terms=Scleroderma,+Systemic&page=2#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Kinases CDC2-CDC28", "description": "Quels sont les principaux facteurs de risque pour les anomalies des kinases ?\nL'âge est-il un facteur de risque ?\nLe tabagisme influence-t-il les kinases ?\nY a-t-il un lien entre l'alimentation et les kinases ?\nLe stress peut-il affecter les kinases ?", "url": "https://questionsmedicales.fr/mesh/D042846?mesh_terms=Scleroderma,+Systemic&page=2#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une dysfonction des kinases CDC2-CDC28 ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Le diagnostic repose sur des tests génétiques et des analyses de protéines spécifiques." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour évaluer l'activité des kinases CDC2-CDC28 ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des tests biochimiques et des dosages enzymatiques sont utilisés pour mesurer leur activité." } }, { "@type": "Question", "name": "Les biopsies peuvent-elles aider au diagnostic ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les biopsies peuvent révéler des anomalies dans l'expression des kinases CDC2-CDC28." } }, { "@type": "Question", "name": "Quels marqueurs biologiques sont associés aux kinases CDC2-CDC28 ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Des marqueurs comme cyclines et phosphorylations spécifiques sont souvent analysés." } }, { "@type": "Question", "name": "Les tests génétiques sont-ils nécessaires pour le diagnostic ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les tests génétiques peuvent identifier des mutations affectant les kinases CDC2-CDC28." } }, { "@type": "Question", "name": "Quels symptômes indiquent une anomalie des kinases CDC2-CDC28 ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes comme la croissance cellulaire anormale ou des troubles du cycle cellulaire peuvent survenir." } }, { "@type": "Question", "name": "Les troubles de la division cellulaire sont-ils liés aux kinases CDC2-CDC28 ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des anomalies dans ces kinases peuvent entraîner des troubles de la division cellulaire." } }, { "@type": "Question", "name": "Peut-on observer des anomalies morphologiques cellulaires ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des anomalies morphologiques peuvent être observées dans les cellules affectées." } }, { "@type": "Question", "name": "Les cancers sont-ils liés aux dysfonctionnements des kinases CDC2-CDC28 ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des dysfonctionnements peuvent contribuer à la carcinogenèse et à la progression tumorale." } }, { "@type": "Question", "name": "Y a-t-il des signes cliniques spécifiques à surveiller ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Des signes comme l'hyperplasie ou des anomalies dans le cycle cellulaire doivent être surveillés." } }, { "@type": "Question", "name": "Peut-on prévenir les dysfonctionnements des kinases CDC2-CDC28 ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "La prévention passe par un mode de vie sain et la réduction des facteurs de risque environnementaux." } }, { "@type": "Question", "name": "Y a-t-il des mesures préventives spécifiques ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Des dépistages réguliers et une surveillance des antécédents familiaux sont recommandés." } }, { "@type": "Question", "name": "L'alimentation joue-t-elle un rôle dans la prévention ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une alimentation équilibrée peut contribuer à la santé cellulaire et à la prévention." } }, { "@type": "Question", "name": "L'exercice physique peut-il aider à prévenir des anomalies ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exercice régulier favorise la santé cellulaire et peut réduire les risques." } }, { "@type": "Question", "name": "Les vaccinations ont-elles un impact sur les kinases ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Certaines vaccinations peuvent réduire le risque de cancers associés aux dysfonctionnements des kinases." } }, { "@type": "Question", "name": "Quels traitements ciblent les kinases CDC2-CDC28 ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Des inhibiteurs spécifiques des kinases sont utilisés pour traiter les dysfonctionnements associés." } }, { "@type": "Question", "name": "Les thérapies géniques sont-elles une option ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la thérapie génique peut corriger des mutations affectant les kinases CDC2-CDC28." } }, { "@type": "Question", "name": "Comment les inhibiteurs de kinases sont-ils administrés ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Ils peuvent être administrés par voie orale ou intraveineuse, selon le médicament." } }, { "@type": "Question", "name": "Y a-t-il des effets secondaires aux traitements ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des effets secondaires comme la toxicité cellulaire peuvent survenir avec certains traitements." } }, { "@type": "Question", "name": "Les traitements sont-ils personnalisés ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques des kinases." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec des anomalies des kinases ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications comme le cancer, des troubles métaboliques et des anomalies cellulaires peuvent survenir." } }, { "@type": "Question", "name": "Les anomalies des kinases peuvent-elles affecter d'autres systèmes ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elles peuvent avoir des répercussions sur le système immunitaire et d'autres systèmes organiques." } }, { "@type": "Question", "name": "Y a-t-il des risques de résistance aux traitements ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des mutations dans les kinases peuvent entraîner une résistance aux traitements ciblés." } }, { "@type": "Question", "name": "Les complications sont-elles réversibles ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Certaines complications peuvent être réversibles avec un traitement approprié, d'autres non." } }, { "@type": "Question", "name": "Comment gérer les complications liées aux kinases ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "La gestion implique un suivi médical régulier et des ajustements thérapeutiques." } }, { "@type": "Question", "name": "Quels sont les principaux facteurs de risque pour les anomalies des kinases ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent des prédispositions génétiques, l'exposition à des agents cancérigènes et des habitudes de vie." } }, { "@type": "Question", "name": "L'âge est-il un facteur de risque ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le risque d'anomalies des kinases augmente avec l'âge en raison de l'accumulation de mutations." } }, { "@type": "Question", "name": "Le tabagisme influence-t-il les kinases ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le tabagisme est un facteur de risque connu pour des anomalies dans les kinases CDC2-CDC28." } }, { "@type": "Question", "name": "Y a-t-il un lien entre l'alimentation et les kinases ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une alimentation riche en graisses et en sucres peut augmenter le risque d'anomalies." } }, { "@type": "Question", "name": "Le stress peut-il affecter les kinases ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut influencer l'expression et l'activité des kinases CDC2-CDC28." } } ] } ] }

Sources (10000 au total)

Cohort Enrichment Strategies for Progressive Interstitial Lung Disease in Systemic Sclerosis From European Scleroderma Trials and Research.

Enrichment strategies from clinical trials for progressive systemic sclerosis-associated interstitial lung disease (SSc-ILD) have not been tested in a real-life cohort.... Do enrichment strategies for progressive ILD impact efficacy, representativeness, and feasibility in patients with SSc-ILD from the European Scleroderma Trials and Research (EUSTAR) database?... We applied the inclusion criteria of major recent SSc-ILD trials (Study of the Efficacy and Safety of Tocilizumab in Participants With Systemic Sclerosis [focuSSced], Scleroderma Lung Study II [SLS II... In total, 2,258 patients with SSc-ILD were included: 31.2% of the patients met SENSCIS criteria; 5.8% of the patients met SLS II criteria; 1.6% of the patients met focuSSced criteria, and 67.7% (1,529... The application of enrichment criteria from previous clinical trials showed enrichment for progression with variable success, which led to selected patient populations reducing feasibility of recruitm...

Standardized incidence ratios and risk factors for cancer in patients with systemic sclerosis: Data from the Spanish Scleroderma Registry (RESCLE).

Patients with systemic sclerosis (SSc) are at increased risk of cancer, a growing cause of non-SSc-related death among these patients. We analyzed the increased cancer risk among Spanish patients with... Spanish Scleroderma Registry data were analyzed to determine the demographic characteristics of patients with SSc, and logistic regression was used to identify cancer risk factors. SIRs with 95% confi... Of 1930 patients with SSc, 206 had cancer, most commonly breast, lung, hematological, and colorectal cancers. Patients with SSc had increased risks of overall cancer (SIR 1.48, 95% CI 1.36-1.60; P < 0... Spanish patients with SSc had an increased cancer risk compared with the general population. Some characteristics, including specific autoantibodies, may be related to this increased risk....

Scleroderma autoantibodies in guiding monitoring and treatment decisions.

One of the key clinical challenges of systemic sclerosis (SSc) is diversity in clinical presentation, organ involvement and disease progression. Antinuclear autoantibodies (ANA) are central to the dia... There has been further development in delineating clinical patterns in ANA, genetic susceptibility and antigen triggers predisposing to ANA subtypes. Sub-group analysis of recent clinical trials shows... ANA subtyping is likely to be firmly embedded into future classification systems. Beyond informing current management and monitoring of scleroderma patients, ANA subsets have implication on future res...

Drug Repositioning Identifies Six Drug Candidates for Systemic Autoimmune Diseases by Integrative Analyses of Transcriptomes from Scleroderma, Systemic Lupus Erythematosus, and Sjogren's Syndrome.

The mechanisms of systemic autoimmune diseases (ADs) are still not clearly understood. Understanding the etiology of systemic ADs and identifying new therapeutic targets require a systems science appr...

Mental health symptoms in scleroderma during COVID-19: a Scleroderma Patient-centred Intervention Network (SPIN) cohort longitudinal study.

People with systemic sclerosis (SSc) are vulnerable in COVID-19 and face challenges related to shifting COVID-19 risk and protective restrictions. We evaluated mental health symptom trajectories in pe... The longitudinal Scleroderma Patient-centred Intervention Network (SPIN) COVID-19 cohort was launched in April 2020 and included participants from the ongoing SPIN Cohort and external enrolees. Analys... Anxiety symptoms increased in early 2020 but returned to pre-COVID-19 levels by mid-2020 and remained stable through March 2022. Depression symptoms did not initially change but were slightly lower by... People with SSc continue to face COVID-19 challenges related to ongoing risk, the opening of societies, and removal of protective restrictions. People with SSc, in aggregate, appear to be weathering t...

[Autoimmune and inflammatory pathologies associated with systemic scleroderma: Clinical, serological and prognostic profiles. Bi-centric retrospective series in the PACA region].

Systemic sclerosis (SSc) is a rare auto-immune disease, affecting principally women between 40 and 60 years old. It is caracterised by a cutaneous and visceral fibrosis, an alteration of the microvasc... We have analysed the data of a retrospective and bicentrique cohort, from the internal medicine unit of Hôpital Nord in Marseille and from the internal medicine unit of the Hôpital Sainte-Anne in Toul... The cohort included 151 patients including 134 limited cutaneous SSc. Fifty-two (34.4%) patients presented at least one associated auto-immune or inflammatory disease. The association of two connectiv... SSc is often associated with other autoimmune diseases. This interrelation between associated pathologies and SSc, modifying sometimes the evolution of SSc, enhances the need of a personalized follow-...

Juvenile and adult-onset scleroderma: Different clinical phenotypes.

Systemic sclerosis (SSc) represents extremely rare disease with majority of data coming from adults. Studies comparing juvenile- (jSSc) and adult-onset (aSSc) patients are limited. We aimed to compare... A retrospective study among pediatric and adult Scl patients has been performed. Demographic characteristics, clinical features, autoantibody profiles, and treatment data were retrieved from the datab... A total of 158 adults and 58 juvenile Scl patients were identified. The mean age at the disease onset was 37±14.7 vs. 8.8 ± 4.1 years, mean age at diagnosis 42±15.2 vs. 10.4 ± 3.8 years and mean follo... Juvenile and adult-onset Scl represent rarely seen conditions with different clinical phenotypes. Pediatric patients with LS are more commonly seen by pediatric rheumatologists, in contrary to adults....