Targeted lateral pelvic lymph node excision in the setting of total neoadjuvant therapy for rectal cancer.
Targeted lateral pelvic node dissection in the era of total neoadjuvant therapy....
Protéines à répétitions de séquences bêta-transducine : Questions médicales fréquentes
Questions fréquentes et termes MeSH associés
Diagnostic 5
#1
Comment diagnostiquer une anomalie des protéines bêta-transducine ?
Le diagnostic repose sur des tests génétiques et des analyses protéomiques.
#2
Quels tests sont utilisés pour évaluer les protéines bêta-transducine ?
Des tests de Western blot et des techniques de spectrométrie de masse sont courants.
#3
Les biopsies sont-elles nécessaires pour le diagnostic ?
Elles peuvent être nécessaires pour évaluer l'expression des protéines dans les tissus.
#4
Y a-t-il des marqueurs spécifiques pour ces protéines ?
Des marqueurs spécifiques peuvent être identifiés par des anticorps ciblés.
#5
Peut-on utiliser l'imagerie pour le diagnostic ?
L'imagerie peut aider à visualiser des anomalies associées, mais pas directement les protéines.
Symptômes 5
#1
Quels symptômes sont associés aux dysfonctionnements des protéines ?
Les symptômes varient, incluant des troubles neurologiques et des anomalies métaboliques.
#2
Les symptômes sont-ils toujours présents ?
Non, certains individus peuvent être asymptomatiques malgré des anomalies protéiques.
#3
Y a-t-il des symptômes spécifiques à surveiller ?
Des troubles de la vision et des problèmes de coordination peuvent être observés.
#4
Les symptômes évoluent-ils avec le temps ?
Oui, les symptômes peuvent s'aggraver ou évoluer selon la gravité de l'anomalie.
#5
Les symptômes peuvent-ils être confondus avec d'autres maladies ?
Oui, ils peuvent ressembler à ceux d'autres troubles neurologiques ou métaboliques.
Prévention 5
#1
Peut-on prévenir les anomalies des protéines bêta-transducine ?
La prévention est difficile, mais un dépistage génétique peut aider à identifier les risques.
#2
Y a-t-il des mesures préventives recommandées ?
Des conseils sur le mode de vie sain et le suivi médical régulier sont recommandés.
#3
Les antécédents familiaux influencent-ils la prévention ?
Oui, des antécédents familiaux de maladies génétiques augmentent le risque.
#4
Le dépistage prénatal est-il possible ?
Oui, le dépistage prénatal peut identifier certaines anomalies génétiques.
#5
Les vaccinations peuvent-elles aider ?
Les vaccinations ne préviennent pas directement les anomalies protéiques, mais protègent la santé générale.
Traitements 5
#1
Quels traitements sont disponibles pour les anomalies protéiques ?
Les traitements incluent la thérapie génique et des médicaments ciblés.
#2
La physiothérapie est-elle utile ?
Oui, la physiothérapie peut aider à améliorer la fonction motrice et la coordination.
#3
Y a-t-il des traitements expérimentaux ?
Des essais cliniques évaluent de nouvelles approches thérapeutiques pour ces conditions.
#4
Les traitements sont-ils personnalisés ?
Oui, les traitements peuvent être adaptés en fonction du profil génétique du patient.
#5
Les traitements peuvent-ils guérir les anomalies ?
Certains traitements peuvent améliorer les symptômes, mais une guérison complète est rare.
Complications 5
#1
Quelles complications peuvent survenir avec ces anomalies ?
Les complications incluent des troubles neurologiques graves et des déficits fonctionnels.
#2
Les complications sont-elles réversibles ?
Certaines complications peuvent être gérées, mais beaucoup ne sont pas réversibles.
#3
Y a-t-il des risques de maladies associées ?
Oui, les anomalies peuvent augmenter le risque de maladies métaboliques et cardiovasculaires.
#4
Les complications affectent-elles la qualité de vie ?
Oui, elles peuvent significativement réduire la qualité de vie des patients.
#5
Comment gérer les complications ?
La gestion implique un suivi médical régulier et des interventions thérapeutiques adaptées.
Facteurs de risque 5
#1
Quels sont les principaux facteurs de risque ?
Les facteurs incluent des mutations génétiques, des antécédents familiaux et des expositions environnementales.
#2
L'âge joue-t-il un rôle dans le risque ?
Oui, certains risques augmentent avec l'âge, notamment pour les maladies dégénératives.
#3
Les habitudes de vie influencent-elles le risque ?
Oui, un mode de vie malsain peut exacerber les risques associés aux anomalies protéiques.
#4
Y a-t-il des facteurs environnementaux à considérer ?
Oui, l'exposition à des toxines ou à des agents chimiques peut augmenter le risque.
#5
Les facteurs de risque sont-ils modifiables ?
Certains facteurs, comme le mode de vie, sont modifiables, d'autres non.
Contenu validé par Dr Olivier Menir
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 30/04/2025
Contenu vérifié selon les dernières recommandations médicales
Auteurs principaux
Richard A Cerione
4 publications dans cette catégorie
Affiliations :
- Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA; Department of Molecular Medicine, Cornell University, Ithaca, NY 14853, USA. Electronic address: rac1@cornell.edu.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Molecular cell 2019-07-09
-
Probing the mechanism by which the retinal G protein transducin activates its biological effector PDE6.
The Journal of biological chemistry 2023-12-28
-
Reconstitution of the Rhodopsin-Transducin Complex into Lipid Nanodiscs.
Methods in molecular biology (Clifton, N.J.)
-
Purification of the Rhodopsin-Transducin Complex for Structural Studies.
Methods in molecular biology (Clifton, N.J.)
Yang Gao
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Molecular cell 2019-07-09
-
Reconstitution of the Rhodopsin-Transducin Complex into Lipid Nanodiscs.
Methods in molecular biology (Clifton, N.J.)
-
Purification of the Rhodopsin-Transducin Complex for Structural Studies.
Methods in molecular biology (Clifton, N.J.)
Sekar Ramachandran
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Molecular cell 2019-07-09
-
Reconstitution of the Rhodopsin-Transducin Complex into Lipid Nanodiscs.
Methods in molecular biology (Clifton, N.J.)
-
Purification of the Rhodopsin-Transducin Complex for Structural Studies.
Methods in molecular biology (Clifton, N.J.)
Jon W Erickson
3 publications dans cette catégorie
Affiliations :
- Department of Chemistry and Chemical Biology, Cornell University, Ithaca, NY 14853, USA.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Structures of the Rhodopsin-Transducin Complex: Insights into G-Protein Activation.
Molecular cell 2019-07-09
-
Reconstitution of the Rhodopsin-Transducin Complex into Lipid Nanodiscs.
Methods in molecular biology (Clifton, N.J.)
-
Purification of the Rhodopsin-Transducin Complex for Structural Studies.
Methods in molecular biology (Clifton, N.J.)
Yeonji Chang
3 publications dans cette catégorie
Affiliations :
- Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs.
Proceedings of the National Academy of Sciences of the United States of America 2023-01-09
-
CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs.
bioRxiv : the preprint server for biology 2023-10-16
-
CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs.
Molecular cell 2024-01-30
Rachel Anderson
3 publications dans cette catégorie
Affiliations :
- Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
- Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs.
Proceedings of the National Academy of Sciences of the United States of America 2023-01-09
-
CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs.
bioRxiv : the preprint server for biology 2023-10-16
-
CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs.
Molecular cell 2024-01-30
Ankur Jain
3 publications dans cette catégorie
Affiliations :
- Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
- Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs.
Proceedings of the National Academy of Sciences of the United States of America 2023-01-09
-
CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs.
bioRxiv : the preprint server for biology 2023-10-16
-
CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs.
Molecular cell 2024-01-30
Jiang Li
2 publications dans cette catégorie
Affiliations :
- Guangdong Engineering Research Center of Oral Restoration and Reconstruction, Affiliated Stomatology Hospital of Guangzhou Medical University, Guangzhou, 510180, China.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Isolation and characterization of β-transducin repeat-containing protein ligands screened using a high-throughput screening system.
Oncology research 2023-07-21
-
PTEN downregulates WD repeat‑containing protein 66 in salivary adenoid cystic carcinoma.
Oncology reports 2018-12-13
Dmitri Zorine
2 publications dans cette catégorie
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
De novo design of alpha-beta repeat proteins.
bioRxiv : the preprint server for biology 2024-06-16
-
Hallucination of closed repeat proteins containing central pockets.
Nature structural & molecular biology 2023-09-28
David Baker
2 publications dans cette catégorie
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
De novo design of alpha-beta repeat proteins.
bioRxiv : the preprint server for biology 2024-06-16
-
Hallucination of closed repeat proteins containing central pockets.
Nature structural & molecular biology 2023-09-28
Stefan Knapp
2 publications dans cette catégorie
Affiliations :
- Department of Biochemistry, Chemistry and Pharmacy, Institute for Pharmaceutical Chemistry, Goethe University, Frankfurt, Germany.
- Structural Genomics Consortium, Buchmann Institute for Molecular Life Sciences, Goethe University, Frankfurt, Germany.
- German Cancer Consortium (DKTK), German Cancer Research Center (DKFZ), Heidelberg, Germany.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
A Toolbox for the Generation of Chemical Probes for Baculovirus IAP Repeat Containing Proteins.
Frontiers in cell and developmental biology 2022-05-26
-
Design, Synthesis, and Evaluation of WD-Repeat-Containing Protein 5 (WDR5) Degraders.
Journal of medicinal chemistry 2021-05-13
Rikard Frederiksen
2 publications dans cette catégorie
Affiliations :
- Department of Ophthalmology and Jules Stein Eye Institute, University of California, Los Angeles, California 90095-7000.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Rod Photoreceptors Avoid Saturation in Bright Light by the Movement of the G Protein Transducin.
The Journal of neuroscience : the official journal of the Society for Neuroscience 2021-02-16
-
Elementary response triggered by transducin in retinal rods.
Proceedings of the National Academy of Sciences of the United States of America 2019-02-22
Mehwish Anwer
2 publications dans cette catégorie
Affiliations :
- A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2).
Neuroscience 2019-07-27
-
Acute Downregulation of Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 after Experimental Traumatic Brain Injury.
Journal of neurotrauma 2019-12-05
Noora Puhakka
2 publications dans cette catégorie
Affiliations :
- A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2).
Neuroscience 2019-07-27
-
Acute Downregulation of Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 after Experimental Traumatic Brain Injury.
Journal of neurotrauma 2019-12-05
Xavier Ekolle Ndode-Ekane
2 publications dans cette catégorie
Affiliations :
- A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2).
Neuroscience 2019-07-27
-
Acute Downregulation of Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 after Experimental Traumatic Brain Injury.
Journal of neurotrauma 2019-12-05
Asla Pitkänen
2 publications dans cette catégorie
Affiliations :
- A. I. Virtanen Institute for Molecular Sciences, University of Eastern Finland, Kuopio, Finland. Electronic address: asla.pitkanen@uef.fi.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Genotype and Injury Effect on the Expression of a Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 (SRPX2).
Neuroscience 2019-07-27
-
Acute Downregulation of Novel Hypothalamic Protein Sushi Repeat-Containing Protein X-Linked 2 after Experimental Traumatic Brain Injury.
Journal of neurotrauma 2019-12-05
Shikha Khosla
2 publications dans cette catégorie
Affiliations :
- Department of Endocrinology Diabetes and Metabolism, George Washington University, Washington, USA.
- Department of Endocrinology, Diabetes and Metabolism, Veterans Affairs Medical Center, Washington, USA.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
Pablo Mier
2 publications dans cette catégorie
Affiliations :
- Faculty of Biology, Johannes Gutenberg University of Mainz, 55128 Mainz, Germany. Electronic address: munoz@uni-mainz.de.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Repeatability in protein sequences.
Journal of structural biology 2019-08-10
-
CRISPR sequences are sometimes erroneously translated and can contaminate public databases with spurious proteins containing spaced repeats.
Database : the journal of biological databases and curation
Miguel A Andrade-Navarro
2 publications dans cette catégorie
Affiliations :
- Faculty of Biology, Johannes Gutenberg University of Mainz, 55128 Mainz, Germany. Electronic address: andrade@uni-mainz.de.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Repeatability in protein sequences.
Journal of structural biology 2019-08-10
-
CRISPR sequences are sometimes erroneously translated and can contaminate public databases with spurious proteins containing spaced repeats.
Database : the journal of biological databases and curation
Michael R Das
2 publications dans cette catégorie
Affiliations :
- Whitehead Institute for Biomedical Research, Cambridge, MA 02142.
- Department of Biology, Massachusetts Institute of Technology, Cambridge, MA 02139.
Publications dans "Protéines à répétitions de séquences bêta-transducine" :
-
Repeat-associated non-AUG translation induces cytoplasmic aggregation of CAG repeat-containing RNAs.
Proceedings of the National Academy of Sciences of the United States of America 2023-01-09
-
CAG repeat expansions create splicing acceptor sites and produce aberrant repeat-containing RNAs.
Molecular cell 2024-01-30
Sources (7946 au total)
Prone position thoracoscopic-assisted total mesoesophageal excision: initial experiences and benefits of lymph node dissection.
Total mesoesophageal excision (TME) is a promising procedure. Prone position thoracoscopic-assisted TME might be a good choice, even without robust evidence yet. Therefore, it is necessary to explore ... We retrospectively analyzed the short-term outcomes regarding intraoperative unplanned events, postoperative complications, and lymphadenectomy in 61 patients who underwent prone position thoracoscopi... Of these sixty-one patients, there were 10, 24 and 27 cases of tumor in the upper, middle, and lower thoracic, respectively. Although there were five cases of unplanned events during surgery, no conve... The prone position thoracoscopic-assisted TME is a safe procedure that is more conducive to thoracic lymph node dissection, especially for middle and lower mediastinum....
Efficacy of octreotide to reduce lymphorrhea and prevent lymphocele after pelvic lymph node excision in gynecological malignancies.
To study the efficacy of octreotide to reduce lymphorrhea and prevent lymphocele after pelvic lymph node excision in gynecological malignancies.... Patients with more than 200 mL of lymph drained per day until postoperative day 3 after pelvic lymph node excision were enrolled. Of the 75 patients, 36 were managed by conservative methods without th... The total and mean daily amount of lymph produced per patient was significantly lower in the octreotide-treated group than in the untreated group. The duration of drain placement was shorter in the oc... The injection of octreotide is effective to reduce lymphorrhea and prevent lymphocele after pelvic lymph node excision in gynecological malignancies....
Subcostal lymph nodes: An unusual sentinel lymph node basin in cutaneous melanoma.
Lymphatic drainage from subcostal nodes, along the costal groove, have not previously been characterized as sites for melanoma drainage and metastasis. This study reports a series of patients with sub... Patients who presented to our institution between 2005 and 2020 with documented cutaneous melanoma and sentinel lymph node biopsy of a subcostal node (sentinel = S), or metastases to subcostal nodes l... Six patients had subcostal sentinel nodes (SNs). Primary sites included the posterior trunk and lateral chest wall. Subcostal nodes were found under ribs 10-12. Subcostal SNs had at least one dimensio... Melanoma can metastasize to subcostal lymph nodes and be found at the time of SN biopsy or identified at recurrence. These small nodes are fed by lymphatic channels that run in the neurovascular bundl...
Lymph Node Positivity of Axillary Reverse Mapping Lymph Nodes at the Time of Axillary Lymph Node Dissection: Two-Site Prospective Trial.
Axillary reverse mapping (ARM) was introduced in 2007 to identify and selectively preserve upper-extremity lymphatics during axillary lymph node surgery to decrease the risk of lymphedema. The patient... Patients undergoing ALND with or without immediate lymphatic reconstruction (ILR) were enrolled in a prospective trial at two institutional sites between April 2018 and Decemeber 2022. This report ana... The inclusion criteria were met by 139 patients, who made up the study population (133 with breast cancer and 6 with other disease). Of the breast cancer patients, 99.2% were female, 35.3% (47/133) we... In the contemporary patient population undergoing ALND, the positivity rate of the ARM LN was relatively high, suggesting that leaving ARM LNs in patients undergoing ALND may not be oncologically safe...
Sentinel Lymph Node Identification in Post Neoadjuvant Chemotherapy Breast Cancer Patients Undergoing Surgical Excision Using Lymphosonography.
This study evaluated the efficacy of lymphosonography in the identification of sentinel lymph nodes (SLNs) in post neoadjuvant chemotherapy patients with breast cancer scheduled to undergo surgical ex... Seventy-nine subjects scheduled for breast cancer surgery with SLN excision completed this IRB-approved study, out of which 18 (23%) underwent neoadjuvant chemotherapy before surgery. Subjects underwe... Seventy-two SLNs were surgically excised from 18 subjects, 29 were positive for blue dye, 63 were positive for radioactive tracer and 57 were positive for Sonazoid. Comparison with blue dye showed tha... Lymphosonography achieved similar accuracy as radioactive tracer and higher accuracy than blue dye for identifying SLNs. The 15 SLNs positive for malignancy were all identified by lymphosonography....
Prediction of nonsentinel lymph node metastasis in acral melanoma with positive sentinel lymph nodes.
Metastasis in a nonsentinel lymph node (non-SLN) is an unfavorable independent prognostic factor in cutaneous melanoma (CM). Recent data did suggest potential value of completion lymph node dissection... This retrospective study enrolled 656 cases of melanoma who underwent sentinel lymph node biopsy at Fudan University Shanghai Cancer Center from 2009 to 2017. We identified 81 SLN + AM patients who un... Ulceration, Clark level, number of deposits in the SLN (NumDep) and maximum size of deposits (MaxSize) are independent risk factors associated with non-SLN metastases. We developed a scoring system th... A scoring system that included ulceration, Clark level, MaxSize, and NumDep is reliable and effective for predicting non-SLN metastasis in SLN-positive AM....
Prognostic Value of Lymph Node Yield, Lymph Node Density, and pN in Oral Cancer.
To investigate thresholds for lymph node yield (LNY), lymph node density (LND), and pN in patients with oral squamous cell carcinoma in relation to previous findings in the literature.... Retrospective register-based study.... Copenhagen Oral Cavity Squamous Cell Carcinoma database.... Appropriate thresholds for LNY, LND, and pN were determined by areas under the curve and subsequently subjected to multivariate analysis. Five-year overall survival and 3-year recurrence-free survival... In total, 413 patients diagnosed with oral squamous cell carcinoma were included. In the pN0 cohort, no superior/prognostic LNY cutoff values were detected. In the pN+ cohort, areas under the curve de... Increased nodal yield, decreased LND, and decreasing number of pN were associated with significantly improved survival outcomes. LNY might serve as a prognosticator of survival as well as a surgical q...
Effect of inguinal lymph node dissection in lymph node negative patients with squamous cell carcinoma of the penis.
The survival benefit of inguinal lymph node dissection (ILND) vs no ILND in patients with squamous cell carcinoma of the penis (SCCP) and the absence of lymph node invasion is unclear. We addressed th... We identified lymph node negative SCCP patients who either underwent ILND (pN0) or clinical examination only (cN0). We tested for the effect of ILND vs no ILND on cancer-specific mortality (CSM) in Ka... Of 2520 SCCP patients, 369 (15%) underwent ILND (pN0) vs 2151 (85%) did not (cN0). The pN0 vs cN0 distribution according to pT stages was as follows: 80 (7%) vs 1092 (93%) in pT1b, and 289 (21%) vs 10... In pT2-3 stage SCCP, a significantly lower CSM was recorded in lymph node negative patients treated with ILND than in their clinical lymph node negative counterparts who did not undergo ILND....
Predictive Value of Jugulo-omohyoid Lymph Nodes in Lateral Lymph Node Metastasis of Papillary Thyroid Cancer.
Jugulo-omohyoid lymph nodes (JOHLN) metastasis has proven to be associated with lateral lymph node metastasis (LLNM). This study aimed to reveal the clinical features and evaluate the predictive value... A total of 550 patients pathologically diagnosed with PTC between October 2015 and January 2020, all of whom underwent thyroidectomy and lateral lymph node dissection, were included in this study.... Thyroiditis, tumor location, tumor size, extra-thyroidal extension, extra-nodal extension, central lymph node metastasis (CLNM), and LLMM were associated with JOHLN. Male, upper lobe tumor, multifocal... JOLHN metastasis could be a clinically sensitive predictor of further LLM. A high-performance nomogram was established, which can provide an individual risk assessment of LNM and guide treatment decis...