questionsmedicales.fr
Enzymes et coenzymes
Enzymes
Complexes multienzymatiques
Proteasome endopeptidase complex
Proteasome endopeptidase complex : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Protéasome
Dysfonctionnement protéique
Biopsie
Évaluation fonctionnelle
Fatigue
Troubles immunitaires
Symptômes
5
Fatigue
Troubles neurologiques
Troubles immunitaires
Réponse immunitaire
Éruptions cutanées
Inflammation
Troubles métaboliques
Dégradation protéique
Troubles cognitifs
Neuropathies
Prévention
5
Alimentation équilibrée
Mode de vie sain
Exercice physique
Santé immunitaire
Examens médicaux
Dysfonctionnements
Sommeil
Fonctions cellulaires
Traitements
5
Inhibiteurs du protéasome
Bortezomib
Thérapie génique
Mutations
Traitements symptomatiques
Douleur
Suppléments nutritionnels
Santé cellulaire
Physiothérapie
Force musculaire
Complications
5
Cancers
Maladies neurodégénératives
Infections
Fonction immunitaire
Maladies auto-immunes
Dysfonction du protéasome
Troubles métaboliques
Dégradation protéique
Troubles cognitifs
Dysfonction du protéasome
Facteurs de risque
5
Âge avancé
Maladies chroniques
Mode de vie sédentaire
Mauvaise alimentation
Expositions environnementales
Toxines
Stress chronique
Dysfonction du protéasome
Infections virales
Fonction du protéasome
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"text": "Des tests de dégradation des protéines et des analyses protéomiques peuvent être effectués."
}
},
{
"@type": "Question",
"name": "Quels marqueurs biologiques sont associés au protéasome ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les niveaux de protéines ubiquitinées et de certains cytokines peuvent indiquer une dysfonction."
}
},
{
"@type": "Question",
"name": "Quels tests génétiques peuvent être utiles ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests pour des mutations dans les gènes codant pour les sous-unités du protéasome peuvent être réalisés."
}
},
{
"@type": "Question",
"name": "Le diagnostic nécessite-t-il une biopsie ?",
"position": 4,
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"@type": "Question",
"name": "Quels symptômes peuvent alerter sur un problème de protéasome ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme la fatigue, la faiblesse musculaire ou des troubles immunitaires peuvent survenir."
}
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{
"@type": "Question",
"name": "Quels symptômes indiquent une défaillance du protéasome ?",
"position": 6,
"acceptedAnswer": {
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"@type": "Question",
"name": "Les troubles immunitaires sont-ils liés au protéasome ?",
"position": 7,
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}
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{
"@type": "Question",
"name": "Peut-on observer des symptômes cutanés ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des éruptions cutanées ou des lésions peuvent survenir en raison d'une inflammation."
}
},
{
"@type": "Question",
"name": "Les troubles métaboliques sont-ils associés ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles métaboliques peuvent résulter d'une dégradation protéique inefficace."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes neurologiques spécifiques ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des troubles cognitifs et des neuropathies peuvent être observés en cas de dysfonction."
}
},
{
"@type": "Question",
"name": "Comment prévenir les dysfonctionnements du protéasome ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée et un mode de vie sain peuvent soutenir la fonction cellulaire."
}
},
{
"@type": "Question",
"name": "Le stress a-t-il un impact sur le protéasome ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut affecter la fonction du protéasome et la santé cellulaire."
}
},
{
"@type": "Question",
"name": "L'exercice physique est-il bénéfique ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer la santé cellulaire et la fonction immunitaire."
}
},
{
"@type": "Question",
"name": "Des examens réguliers sont-ils recommandés ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des examens réguliers peuvent aider à détecter précocement des dysfonctionnements."
}
},
{
"@type": "Question",
"name": "Les habitudes de sommeil influencent-elles le protéasome ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un sommeil de qualité est crucial pour la régulation des fonctions cellulaires."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent le protéasome ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les inhibiteurs du protéasome, comme le bortezomib, sont utilisés dans certains cancers."
}
},
{
"@type": "Question",
"name": "La thérapie génique est-elle une option ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "La thérapie génique visant à corriger les mutations du protéasome est en recherche."
}
},
{
"@type": "Question",
"name": "Des traitements symptomatiques existent-ils ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des traitements pour gérer les symptômes comme la fatigue et la douleur sont disponibles."
}
},
{
"@type": "Question",
"name": "Les suppléments nutritionnels sont-ils bénéfiques ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des suppléments peuvent aider à soutenir la fonction cellulaire et la santé globale."
}
},
{
"@type": "Question",
"name": "La physiothérapie peut-elle aider ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la physiothérapie peut améliorer la force musculaire et la fonction physique."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec une dysfonction du protéasome ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications comme des cancers, des maladies neurodégénératives et des troubles immunitaires peuvent se développer."
}
},
{
"@type": "Question",
"name": "Les infections sont-elles plus fréquentes ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une fonction immunitaire altérée peut augmenter le risque d'infections."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque accru de maladies auto-immunes ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une dysfonction du protéasome peut contribuer au développement de maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "Les troubles métaboliques peuvent-ils s'aggraver ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles métaboliques peuvent s'aggraver en raison d'une dégradation protéique inefficace."
}
},
{
"@type": "Question",
"name": "Des troubles cognitifs peuvent-ils survenir ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles cognitifs peuvent être une complication de la dysfonction du protéasome."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque de dysfonction du protéasome ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'âge avancé, des antécédents familiaux et certaines maladies chroniques augmentent le risque."
}
},
{
"@type": "Question",
"name": "Le mode de vie influence-t-il le risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "Les expositions environnementales sont-elles un facteur ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des toxines environnementales peut affecter la fonction du protéasome."
}
},
{
"@type": "Question",
"name": "Le stress chronique est-il un facteur de risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut contribuer à la dysfonction du protéasome et à des maladies associées."
}
},
{
"@type": "Question",
"name": "Les infections virales peuvent-elles jouer un rôle ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines infections virales peuvent altérer la fonction du protéasome et augmenter le risque."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 02/03/2025
Contenu vérifié selon les dernières recommandations médicales
3 publications dans cette catégorie
Publications dans "Proteasome endopeptidase complex" :
3 publications dans cette catégorie
Publications dans "Proteasome endopeptidase complex" :
3 publications dans cette catégorie
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Affiliations :
College of Pharmacy, Yeungnam University, Gyeongsan, Korea.
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Affiliations :
Division of Life Science, Gyeongsang National University, Jinju, Korea.
Research Institute of Molecular Alchemy, Gyeongsang National University, Jinju, Korea.
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Affiliations :
College of Pharmacy, Yeungnam University, Gyeongsan, Korea.
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Affiliations :
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, 414 E. Clark Street, Lee Medical Building, Vermillion, SD 57069, USA.
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Affiliations :
Division of Basic Biomedical Sciences, Sanford School of Medicine, University of South Dakota, 414 E. Clark Street, Lee Medical Building, Vermillion, SD 57069, USA.
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Affiliations :
Comprehensive Pneumology Center (CPC), University Hospital of the Ludwig-Maximilians-University (LMU) and Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Max-Lebsche Platz 31, 81377 Munich, Germany.
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Affiliations :
Comprehensive Pneumology Center (CPC), University Hospital of the Ludwig-Maximilians-University (LMU) and Helmholtz Zentrum München, Member of the German Center for Lung Research (DZL), Max-Lebsche Platz 31, 81377 Munich, Germany.
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Affiliations :
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK. lukly@cardiff.ac.uk.
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Affiliations :
School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK. lukly@cardiff.ac.uk and Cardiff Catalysis Institute, School of Chemistry, Cardiff University, Main Building, Park Place, Cardiff, CF10 3AT, UK.
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Affiliations :
The Laboratory for Molecular Infection Medicine Sweden, Department of Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden.
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Affiliations :
Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853.
Department of Microbiology, Cornell University, Ithaca, NY 14853.
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Affiliations :
The Laboratory for Molecular Infection Medicine Sweden, Department of Molecular Biology, Umeå University, SE-901 87 Umeå, Sweden.
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Affiliations :
Weill Institute for Cell and Molecular Biology, Cornell University, Ithaca, NY 14853; tdoerr@cornell.edu.
Department of Microbiology, Cornell University, Ithaca, NY 14853.
Cornell Institute of Host-Microbe Interactions and Disease, Cornell University, Ithaca, NY 14853.
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Affiliations :
Centre de Recherche de Biologie Cellulaire de Montpellier (CRBM), CNRS UMR 5237, Université de Montpellier, 1919 Route de Mende, 34293, Montpellier, France.
Publications dans "Proteasome endopeptidase complex" :
2 publications dans cette catégorie
Affiliations :
MRC Laboratory of Molecular Biology, Francis Crick Avenue, Cambridge CB2 0QH, UK.
Publications dans "Proteasome endopeptidase complex" :
This study examined the relationships between training workloads, game workloads, and match performance in an elite netball team....
Ten elite female netball athletes were monitored over a complete season. Training and game external workloads were determined through inertial movement units and expressed as absolute PlayerLoad (PL) ...
Monthly PL, training efficiency index PL, and avgMC PL were statistically significant (P < .05) and positively related to game PL (z = 0.20-0.35, P < .001-.02). For game COD, statistically significant...
Higher monthly workloads are related to higher game workload; however, they are also related to decreases in match performance. Therefore, netball practitioners should consider that increases to train...
The ideal hospitalist workload and optimal way to measure it are not well understood....
To obtain expert consensus on the salient measures of hospitalist workload....
This qualitative study used a 3-round Delphi technique between April 5 and July 13, 2022, involving national experts within and external to the field. Experts included hospitalist clinicians, leaders,...
Three rounds of surveys were conducted, during which participants provided input on the salient measures of hospitalist workload across various domains. In the first round, free-text data collected fr...
Seventeen individuals from 14 organizations, encompassing clinicians, leaders, administrators, and researchers, participated in 3 rounds of surveys. In round 1, participants provided 135 unique qualit...
In this qualitative study measuring hospitalist workload, multiple measures, including those quantifying work demands and the association of those demands with outcomes, were considered relevant for m...
The purpose of the study was to validate WORKLINE, a NICU specific clinician workload model and to evaluate the feasibility of integrating WORKLINE into our EHR....
This was a prospective, observational study of the workload of 42 APPs and physicians in a large academic medical center NICU over a 6-month period. We used regression models with robust clustered sta...
We found significant correlations between WORKLINE and NASA-TLX scores. APP caseload was not significantly associated with WORKLINE scores. We successfully integrated the WORKLINE model into our EHR t...
WORKLINE provides an objective method to quantify the workload of clinicians in the NICU, and for APPs, performed better than caseload numbers to reflect workload. Integrating the WORKLINE model into ...
Live captioning is a challenging task that requires intense concentration to convert audio to text in real-time. Despite the importance of live captioning for accessibility, little is known about the ...
Clinicians that care for hospitalised patients face unprecedented work conditions with exposure to highly infectious disease, exceedingly high patient numbers, and unpredictable work demands, all of w...
We will follow the methodology outlined by Joanna Briggs Institute and Arksey and O'Malley to conduct a comprehensive search of major electronic databases including Ovid Medline (PubMed), Embase (Emba...
This review does not require ethics approval though all included studies will be screened to ensure appropriate approval. The synthesis of this literature will provide a better understanding of the cu...
to analyze midwives' employment situation of midwives and detect their workload measurement needs....
a mixed methodology (quantitative and qualitative), observational, descriptive and cross-sectional study. Two phases were carried out. The first methodological phase consisted of conducting semi-struc...
90.3% of midwives have work overload, since for 80.6% the midwife-pregnant mother ratio is not well established, since the mean execution time of a Nursing Intervention Classification (NIC) interventi...
the need to generate an instrument that considers the diversity of Nursing Intervention Classification (NIC) interventions that develop within the labor room is ratified....
Tillman et al. (2017) used evidence-accumulation modeling to ascertain the effects of a conversation (either with a passenger or on a hands-free cell phone) on a drivers' mental workload. They found t...
This integrative review will examine the current literature assessing student workload, outcomes of increased workload and cognitive load, and approaches to evaluate and reduce student workload. Recom...
Literature supports that perceptions of heavy workload can influence students' approach to learning and lead to the adoption of surface learning rather than a deep approach that involves higher-order ...
Cognitive overload is multifactorial and complicated, given the increased standards of professional education accreditation and licensure requirements. As the Academy deliberately considers methods to...
Research has not yet quantified the effects of workload or duty hours on the accuracy of radiologists. With the exception of a brief reduction in imaging studies during the 2020 peak of the COVID-19 p...
In aviation, any detail can have massive consequences. Among the potential sources of failure, human error is still the most troublesome to handle. Therefore, research concerning the management of men...