Comment diagnostiquer une activation des JNK ?

Des tests de signalisation cellulaire et des analyses protéomiques peuvent être utilisés.

Quels biomarqueurs indiquent l'activation des JNK ?

Des niveaux élevés de protéines phosphorylées c-Jun peuvent indiquer une activation.

Les tests génétiques sont-ils utiles pour les JNK ?

Oui, des tests peuvent identifier des mutations affectant la voie JNK.

Quels examens d'imagerie sont utilisés pour les JNK ?

L'imagerie par résonance magnétique peut aider à visualiser des effets cellulaires.

Peut-on mesurer l'activité des JNK dans le sang ?

Des échantillons sanguins peuvent être analysés pour des marqueurs d'activation.

Quels symptômes sont liés à l'activation des JNK ?

L'activation peut entraîner inflammation, apoptose et dysfonction cellulaire.

Les JNK sont-ils impliqués dans des maladies ?

Oui, ils sont associés à des maladies comme le cancer et les maladies neurodégénératives.

Comment les JNK affectent-ils la douleur ?

Ils modulent la signalisation de la douleur, contribuant à des douleurs chroniques.

Les JNK influencent-ils le métabolisme ?

Oui, ils jouent un rôle dans la régulation du métabolisme énergétique.

Y a-t-il des symptômes neurologiques associés aux JNK ?

Des troubles cognitifs et des troubles de l'humeur peuvent être observés.

Comment prévenir l'activation des JNK ?

Un mode de vie sain, incluant une alimentation équilibrée et de l'exercice, peut aider.

Le stress influence-t-il les JNK ?

Oui, le stress oxydatif peut activer les JNK, donc la gestion du stress est cruciale.

Les antioxydants aident-ils à prévenir l'activation des JNK ?

Oui, les antioxydants peuvent réduire le stress oxydatif et l'activation des JNK.

L'exercice physique prévient-il l'activation des JNK ?

Oui, l'exercice régulier peut moduler positivement l'activité des JNK.

Les habitudes alimentaires influencent-elles les JNK ?

Une alimentation riche en nutriments peut réduire l'activation des JNK.

Quels traitements ciblent les JNK ?

Des inhibiteurs spécifiques des JNK sont en développement pour diverses maladies.

Les anti-inflammatoires affectent-ils les JNK ?

Oui, certains anti-inflammatoires peuvent moduler l'activité des JNK.

La thérapie génique peut-elle cibler les JNK ?

La thérapie génique est explorée pour corriger des dysfonctionnements des JNK.

Les traitements naturels influencent-ils les JNK ?

Certaines plantes médicinales peuvent avoir un effet sur l'activation des JNK.

Les traitements anticancéreux ciblent-ils les JNK ?

Oui, des traitements anticancéreux visent à inhiber les voies JNK dans les cellules tumorales.

Quelles complications sont liées à l'activation des JNK ?

L'activation excessive des JNK peut entraîner des maladies inflammatoires et cancéreuses.

Les JNK sont-ils liés à des complications cardiovasculaires ?

Oui, l'activation des JNK est associée à des maladies cardiovasculaires.

Les JNK influencent-ils le vieillissement cellulaire ?

Oui, une activation prolongée des JNK peut accélérer le vieillissement cellulaire.

Y a-t-il des complications neurologiques liées aux JNK ?

Oui, l'activation des JNK est impliquée dans des troubles neurodégénératifs.

Les JNK sont-ils impliqués dans des complications métaboliques ?

Oui, ils sont liés à des troubles métaboliques comme le diabète.

Quels facteurs de risque influencent les JNK ?

Le stress, l'inflammation chronique et l'obésité sont des facteurs de risque connus.

L'alimentation affecte-t-elle les JNK ?

Oui, une alimentation riche en graisses saturées peut augmenter l'activation des JNK.

Le tabagisme influence-t-il les JNK ?

Oui, le tabagisme est un facteur de risque qui peut activer les JNK.

L'exposition à des toxines affecte-t-elle les JNK ?

Oui, l'exposition à des toxines environnementales peut activer les JNK.

Le manque d'exercice est-il un facteur de risque pour les JNK ?

Oui, un mode de vie sédentaire peut augmenter le risque d'activation des JNK.

JNK Mitogen-Activated Protein Kinases - Informations médicales vérifiées

Reliability of point-of-care ultrasound for measuring quadriceps femoris muscle thickness.

Oct 2022

DOI: 10.23736/S1973-9087.22.07432-9 PMID: 36052891

Point-of-care ultrasound can be used to assess muscle thickness. However, its reliability has not been fully evaluated.... This study aimed to assess the intrarater and inter-rater reliability of point-of-care ultrasound for the estimation of quadriceps and rectus femoris thickness in patients from a rehabilitation settin... This is a cross-sectional study.... This study was conducted at the Department of Physical Medicine and Rehabilitation of a tertiary care hospital.... Twenty-nine inpatients consecutively selected after admission.... Four observers, two trained and two untrained, used point-of-care ultrasound to measure quadriceps femoris and rectus femoris thickness. Each observer performed two measurements followed by a second s... Both intrarater and inter-rater ICC were higher than 0.888 for both quadriceps and rectus femoris measurements. Reliability was highest when ICC were calculated based on the average of two measurement... These results suggest that point-of-care ultrasound is a reliable option to measure muscle thickness of knee extensors by the same or different observers.... Measuring knee extensors thickness may aid to adequately modulate treatment choices in patients with disability. This study suggests that quadriceps and rectus femoris muscle thickness measured after ...

Cross-Sectional Studies Humans Point-of-Care Systems Quadriceps Muscle Reproducibility of Results +1 autres

Motor point heatmap guide for neuromuscular electrical stimulation of the quadriceps muscle.

Jun 2023

DOI: 10.1016/j.jelekin.2023.102771 PMID: 37054655

To create an anatomical chart that indicates the probability of finding a motor point (MP) in different areas of the quadriceps muscle.... On 31 healthy adults, the individual anatomy of the vastus medialis (VM), rectus femoris (RF) and vastus lateralis (VL) was determined using ultrasound. Thereafter, a 3 Hz neuromuscular electrical sti... The heat-map displayed the two best 3x3cm areas, over VL and VM respectively, each with a probability greater than 50% of finding a MP and a higher probability compared to all other areas (p <.05). RF... Large inter-individual variations in location, and number of MPs were found, but the heat-map displayed areas with higher probability of finding a MP and can be used to facilitate NMES-application....

Adult Humans Quadriceps Muscle Muscle, Skeletal Lower Extremity +3 autres

Ultrasound quadriceps muscle thickness is variably associated with frailty in haemodialysis recipients.

18 01 2023

DOI: 10.1186/s12882-022-03043-8 PMID: 36653750

Ultrasonographic quantitation of quadriceps muscle mass is increasingly used for assessment of sarcopenia, but its relationship with frailty in haemodialysis recipients is not known. This study explor... This was an exploratory analysis of a subgroup of adult prevalent (≥3 months) haemodialysis recipients deeply phenotyped for frailty. Ultrasound assessment of BATT was obtained with participants at an... In total 223 study participants had ultrasound measurements. Frailty ranged from 34% for FP to 58% for FI. BATT was associated with increasing frailty on simple linear regression by all frailty tools,... Ultrasound measures of quadriceps thickness is variably associated with frailty in prevalent haemodialysis recipients, dependent upon the frailty tool used, but not independent of other variables. Fur... Clinicaltrials.gov : NCT03071107 registered 06/03/2017....

Aged Humans Frail Elderly Frailty Geriatric Assessment +3 autres

Relationship between quadriceps muscle computed tomography measurement and motor function, muscle mass, and sarcopenia diagnosis.

2023

DOI: 10.3389/fendo.2023.1259350 PMID: 38047116

The quadriceps muscle is one of the human body's largest and most clinically important muscles and is evaluated using mid-thigh computed tomography (CT); however, its relationship with motor function ... A total of 472 middle-aged and older community dwellers (254 men and 218 women) aged ≥40 years (mean age: 62.3 years) were included in this study. The quantity and quality of the quadriceps muscle wer... In men, CSA and CSA×CTV were significantly associated with seven of the eight motor functions (p<0.05), excluding only balance ability. BMI-corrected CSA was significantly correlated with all eight mo... The present results showed that a single CT image of the quadriceps muscle at the mid-thigh is useful for diagnosing sarcopenic changes, such as loss of muscle mass, muscle weakness, and muscle functi...

Middle Aged Male Humans Female Aged +5 autres

Immunohistochemical analysis of the quadriceps femoris muscle before and after total knee arthroplasty.

Jan 2023

DOI: 10.1016/j.knee.2022.10.010 PMID: 36403397

The number of total knee arthroplasties (TKA) has increased steadily with the aging of the population. This surgical procedure is recognized for its success in pain relief and restoration of knee func... Muscle biopsies (VM and VL muscles) were collected from patients previously submitted to TKA via the medial parapatellar route and undergoing TKA revision (main group, n = 9) and patients with osteoar... The normal mosaic pattern of the medial and lateral knee muscles was observed in the main and control groups, with no evidence of peripheral nerve damage. Notably, 88.9 % of the patients exhibited mil... The medial parapatellar incision for TKA surgical access does not generate definitive morphological changes in the VM and VL muscle fibers but may contribute to VL atrophy....

Humans Arthroplasty, Replacement, Knee Quadriceps Muscle Knee Joint Knee +1 autres

Association of Regional Muscle Thickness and Echo Intensity with Muscle Volume, Intramuscular Adipose Tissue, and Strength of the Quadriceps Femoris.

2023

DOI: 10.2147/CIA.S424504 PMID: 37724172

This study aimed to investigate the association of muscle thickness (MT) and echo intensity (EI) obtained at different regions along the muscle length with muscle volume (MV), intramuscular adipose ti... A total of 135 community-dwelling adults (64 men and 71 women) participated in the study. Ultrasound scanning of the rectus femoris (RF) and vastus intermedius (VI) was performed at three locations (f... The correlation between RF-MT and RF-MV weakened as scanning approached the distal thigh, and the difference between the coefficients for the scanning locations was significant for women. However, the... The results of this study suggest that ultrasound measurements at the distal thigh can predict MV, IntraMAT, and muscle strength of the QF to the same degree as those at the mid-thigh....

Male Female Humans Quadriceps Muscle Thigh +3 autres

Wearable Neuromuscular Electrical Stimulation on Quadriceps Muscle Can Increase Venous Flow.

Dec 2023

DOI: 10.1007/s10439-023-03349-0 PMID: 37598135

Neuromuscular electrical stimulation (NMES) of the quadriceps (Q) may increase venous blood flow to reduce the risk of venous thromboembolism. This study assessed whether Q-NMES pants could increase p...

Humans Quadriceps Muscle Venous Thromboembolism Muscle Contraction Electric Stimulation Therapy +3 autres

Comparison of The Effect of High- and Low-Frequency Vibration Foam Rolling on The Quadriceps Muscle.

09 2022

DOI: 10.52082/jssm.2022.376 PMID: 36157391

Vibration foam rolling (VFR) intervention has recently gained attention in sports and rehabilitation settings since the superimposed vibration with foam rolling can affect several physiological system...

Humans Isometric Contraction Male Muscle Strength Quadriceps Muscle +2 autres

Sex differences in quadriceps and inspiratory muscle fatigability following high-intensity cycling.

Mar 2023

DOI: 10.1016/j.jsams.2023.02.006 PMID: 36863893

As females have been hypothesized to have more fatigue resistant inspiratory muscles, this study aimed to compare the development of inspiratory and leg muscle fatigue between males and females follow... Cross-sectional comparison.... 17 healthy young males (27 ± 6 years, V̇O... Time to exhaustion was similar between sexes (p = 0.270, 95% CI -2.4 - 0.7 min). MVC of the quadriceps was lower after cycling for males (83.9 ± 11.5% vs. 94.0 ± 12.0% of baseline for females, p = 0.0... Females incur similar peripheral fatigue in the quadriceps and inspiratory muscles compared with men following high-intensity cycling, despite smaller reduction in voluntary force. This small differen...

Humans Male Female Sex Characteristics Cross-Sectional Studies +5 autres

Evaluation of Changes in Quadriceps Femoris Muscle in Critically III Children Using Ultrasonography.

06 2023

DOI: 10.1007/s12098-022-04220-1 PMID: 35834126

To measure changes in muscle thickness and echogenicity, reflecting muscle bulk and quality, respectively, of quadriceps femoris (QF), in critically ill children.... This study was done on 58 children aged 1-18 y requiring mechanical ventilation, admitted in a pediatric intensive care unit (PICU) of a tertiary care hospital from January 2018 to June 2019. QF thick... The median muscle thickness of QF was 1.58 cm, and vastus intermedius and rectus femoris echogenicity was 35.5 and 25.88 units, respectively in the present cohort, with median age of 6 y. Only 36 of t... There was a significant change in rectus femoris echogenicity, but not in QF thickness. Echogenicity rather than muscle thickness may be a more sensitive marker for changes in muscle properties....

Humans Child Quadriceps Muscle Intensive Care Units, Pediatric Ultrasonography +2 autres

JNK Mitogen-Activated Protein Kinases : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Mitogen-Activated Protein Kinase 8

Mitogen-Activated Protein Kinase 9

Mitogen-Activated Protein Kinase 10

Auteurs principaux

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