Titre : ATP-dependent proteases

ATP-dependent proteases : Questions médicales fréquentes

Termes MeSH sélectionnés :

Monocytes
{ "@context": "https://schema.org", "@graph": [ { "@type": "MedicalWebPage", "name": "ATP-dependent proteases : Questions médicales les plus fréquentes", "headline": "ATP-dependent proteases : Comprendre les symptômes, diagnostics et traitements", "description": "Guide complet et accessible sur les ATP-dependent proteases : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.", "datePublished": "2024-05-23", "dateModified": "2025-02-17", "inLanguage": "fr", "medicalAudience": [ { "@type": "MedicalAudience", "name": "Grand public", "audienceType": "Patient", "healthCondition": { "@type": "MedicalCondition", "name": "ATP-dependent proteases" }, "suggestedMinAge": 18, "suggestedGender": "unisex" }, { "@type": "MedicalAudience", "name": "Médecins", "audienceType": "Physician", "geographicArea": { "@type": "AdministrativeArea", "name": "France" } }, { "@type": "MedicalAudience", "name": "Chercheurs", "audienceType": "Researcher", "geographicArea": { "@type": "AdministrativeArea", "name": "International" } } ], "reviewedBy": { "@type": "Person", "name": "Dr Olivier Menir", "jobTitle": "Expert en Médecine", "description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale", "url": "/static/pages/docteur-olivier-menir.html", "alumniOf": { "@type": "EducationalOrganization", "name": "Université Paris Descartes" } }, "isPartOf": { "@type": "MedicalWebPage", "name": "ATPases associated with diverse cellular activities", "url": "https://questionsmedicales.fr/mesh/D000074183", "about": { "@type": "MedicalCondition", "name": "ATPases associated with diverse cellular activities", "code": { "@type": "MedicalCode", "code": "D000074183", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.157.025.750" } } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "ATP-dependent endopeptidases", "alternateName": "ATP-Dependent Endopeptidases", "url": "https://questionsmedicales.fr/mesh/D057065", "about": { "@type": "MedicalCondition", "name": "ATP-dependent endopeptidases", "code": { "@type": "MedicalCode", "code": "D057065", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.157.025.750.032.099" } }, "hasPart": [ { "@type": "MedicalWebPage", "name": "Protease La", "alternateName": "Protease La", "url": "https://questionsmedicales.fr/mesh/D049070", "about": { "@type": "MedicalCondition", "name": "Protease La", "code": { "@type": "MedicalCode", "code": "D049070", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.157.025.750.032.099.750" } } } ] } ], "about": { "@type": "MedicalCondition", "name": "ATP-dependent proteases", "alternateName": "ATP-Dependent Proteases", "code": { "@type": "MedicalCode", "code": "D049069", "codingSystem": "MeSH" } }, "author": [ { "@type": "Person", "name": "Zhou Sha", "url": "https://questionsmedicales.fr/author/Zhou%20Sha", "affiliation": { "@type": "Organization", "name": "Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, 44106, USA." } }, { "@type": "Person", "name": "Jennifer Fishovitz", "url": "https://questionsmedicales.fr/author/Jennifer%20Fishovitz", "affiliation": { "@type": "Organization", "name": "Department of Chemistry and Physics, Saint Mary's College, Notre Dame, Indiana, 46556, USA." } }, { "@type": "Person", "name": "Sujatha Chilakala", "url": "https://questionsmedicales.fr/author/Sujatha%20Chilakala", "affiliation": { "@type": "Organization", "name": "Department of Chemistry, Cleveland State University, Cleveland, Ohio, 44115, USA." } }, { "@type": "Person", "name": "Yan Xu", "url": "https://questionsmedicales.fr/author/Yan%20Xu", "affiliation": { "@type": "Organization", "name": "Department of Chemistry, Cleveland State University, Cleveland, Ohio, 44115, USA." } }, { "@type": "Person", "name": "Irene Lee", "url": "https://questionsmedicales.fr/author/Irene%20Lee", "affiliation": { "@type": "Organization", "name": "Department of Chemistry, Case Western Reserve University, Cleveland, Ohio, 44106, USA." } } ], "citation": [ { "@type": "ScholarlyArticle", "name": "Epigenetic Regulation of IFI44L Expression in Monocytes Affects the Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus Erythematosus.", "datePublished": "2022-05-10", "url": "https://questionsmedicales.fr/article/35592687", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1155/2022/4053038" } }, { "@type": "ScholarlyArticle", "name": "Phenotypic and Functional Heterogeneity of Monocytes and Macrophages.", "datePublished": "2023-09-25", "url": "https://questionsmedicales.fr/article/37833973", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.3390/ijms241914525" } }, { "@type": "ScholarlyArticle", "name": "Defining the Role of Monocytes in Sjögren's Syndrome.", "datePublished": "2022-10-23", "url": "https://questionsmedicales.fr/article/36361554", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.3390/ijms232112765" } }, { "@type": "ScholarlyArticle", "name": "Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro.", "datePublished": "2022-06-29", "url": "https://questionsmedicales.fr/article/35768823", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1186/s12974-022-02535-6" } }, { "@type": "ScholarlyArticle", "name": "Deciphering the role of monocyte and monocyte distribution width (MDW) in COVID-19: an updated systematic review and meta-analysis.", "datePublished": "2023-01-11", "url": "https://questionsmedicales.fr/article/36626568", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1515/cclm-2022-0936" } } ], "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "questionsmedicales.fr", "item": "https://questionsmedicales.fr" }, { "@type": "ListItem", "position": 2, "name": "Acides aminés, peptides et protéines", "item": "https://questionsmedicales.fr/mesh/D000602" }, { "@type": "ListItem", "position": 3, "name": "Protéines", "item": "https://questionsmedicales.fr/mesh/D011506" }, { "@type": "ListItem", "position": 4, "name": "Protéines de transport", "item": "https://questionsmedicales.fr/mesh/D002352" }, { "@type": "ListItem", "position": 5, "name": "Protéines AAA", "item": "https://questionsmedicales.fr/mesh/D000074582" }, { "@type": "ListItem", "position": 6, "name": "ATPases associated with diverse cellular activities", "item": "https://questionsmedicales.fr/mesh/D000074183" }, { "@type": "ListItem", "position": 7, "name": "ATP-dependent proteases", "item": "https://questionsmedicales.fr/mesh/D049069" } ] } }, { "@type": "MedicalWebPage", "name": "Article complet : ATP-dependent proteases - Questions et réponses", "headline": "Questions et réponses médicales fréquentes sur ATP-dependent proteases", "description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.", "datePublished": "2025-05-09", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur ATP-dependent proteases", "description": "Comment diagnostiquer une dysfonction des protéases ATP-dépendantes ?\nQuels tests sanguins sont utiles pour évaluer ces protéases ?\nLes biopsies sont-elles nécessaires pour le diagnostic ?\nQuels symptômes peuvent indiquer un problème avec ces enzymes ?\nPeut-on utiliser l'imagerie pour diagnostiquer des troubles liés aux protéases ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Monocytes&page=3#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur ATP-dependent proteases", "description": "Quels sont les symptômes d'une déficience en protéases ATP-dépendantes ?\nLes troubles neurologiques sont-ils liés à ces protéases ?\nComment la dégradation des protéines affecte-t-elle la santé ?\nY a-t-il des signes cutanés associés à ces troubles ?\nLes douleurs musculaires peuvent-elles être un symptôme ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Monocytes&page=3#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur ATP-dependent proteases", "description": "Comment prévenir les troubles liés aux protéases ?\nL'exercice physique joue-t-il un rôle préventif ?\nLes contrôles médicaux réguliers sont-ils importants ?\nY a-t-il des vaccins pour prévenir ces troubles ?\nLe stress peut-il affecter la fonction des protéases ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Monocytes&page=3#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur ATP-dependent proteases", "description": "Quels traitements existent pour les troubles liés aux protéases ?\nLes suppléments alimentaires peuvent-ils aider ?\nLa thérapie génique est-elle une option ?\nLes médicaments anti-inflammatoires sont-ils utiles ?\nComment la physiothérapie peut-elle aider ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Monocytes&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur ATP-dependent proteases", "description": "Quelles complications peuvent survenir avec des troubles protéolytiques ?\nLes complications cardiovasculaires sont-elles possibles ?\nComment les troubles protéolytiques affectent-ils le système immunitaire ?\nY a-t-il un risque accru de cancer ?\nLes troubles neurologiques peuvent-ils s'aggraver ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Monocytes&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur ATP-dependent proteases", "description": "Quels sont les facteurs de risque pour les troubles protéolytiques ?\nLe mode de vie influence-t-il ces risques ?\nLes maladies auto-immunes sont-elles un facteur de risque ?\nLe stress chronique est-il un facteur de risque ?\nL'exposition à des toxines peut-elle augmenter le risque ?", "url": "https://questionsmedicales.fr/mesh/D049069?mesh_terms=Monocytes&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une dysfonction des protéases ATP-dépendantes ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests enzymatiques et des analyses protéomiques peuvent être utilisés." } }, { "@type": "Question", "name": "Quels tests sanguins sont utiles pour évaluer ces protéases ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des dosages d'enzymes spécifiques et des marqueurs de dégradation protéique sont recommandés." } }, { "@type": "Question", "name": "Les biopsies sont-elles nécessaires pour le diagnostic ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des biopsies peuvent aider à évaluer l'activité des protéases dans les tissus." } }, { "@type": "Question", "name": "Quels symptômes peuvent indiquer un problème avec ces enzymes ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes comme la fatigue, la perte de poids et des troubles métaboliques peuvent survenir." } }, { "@type": "Question", "name": "Peut-on utiliser l'imagerie pour diagnostiquer des troubles liés aux protéases ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "L'imagerie peut aider à visualiser des anomalies tissulaires, mais pas directement les protéases." } }, { "@type": "Question", "name": "Quels sont les symptômes d'une déficience en protéases ATP-dépendantes ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Fatigue, troubles digestifs, et accumulation de protéines mal repliées peuvent se manifester." } }, { "@type": "Question", "name": "Les troubles neurologiques sont-ils liés à ces protéases ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des dysfonctionnements peuvent entraîner des troubles neurologiques et cognitifs." } }, { "@type": "Question", "name": "Comment la dégradation des protéines affecte-t-elle la santé ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Une dégradation inappropriée peut mener à des maladies dégénératives et à l'inflammation." } }, { "@type": "Question", "name": "Y a-t-il des signes cutanés associés à ces troubles ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Des éruptions cutanées et des problèmes de cicatrisation peuvent être observés." } }, { "@type": "Question", "name": "Les douleurs musculaires peuvent-elles être un symptôme ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des douleurs musculaires peuvent survenir en raison d'une dégradation protéique anormale." } }, { "@type": "Question", "name": "Comment prévenir les troubles liés aux protéases ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée et un mode de vie sain peuvent aider à maintenir leur fonction." } }, { "@type": "Question", "name": "L'exercice physique joue-t-il un rôle préventif ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exercice régulier peut améliorer la santé musculaire et enzymatique." } }, { "@type": "Question", "name": "Les contrôles médicaux réguliers sont-ils importants ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des bilans réguliers peuvent détecter précocement des anomalies protéolytiques." } }, { "@type": "Question", "name": "Y a-t-il des vaccins pour prévenir ces troubles ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Actuellement, il n'existe pas de vaccins spécifiques pour ces troubles enzymatiques." } }, { "@type": "Question", "name": "Le stress peut-il affecter la fonction des protéases ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut perturber l'équilibre enzymatique et la santé cellulaire." } }, { "@type": "Question", "name": "Quels traitements existent pour les troubles liés aux protéases ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Des thérapies enzymatiques et des médicaments ciblant les voies protéolytiques sont utilisés." } }, { "@type": "Question", "name": "Les suppléments alimentaires peuvent-ils aider ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certains suppléments peuvent soutenir la fonction protéolytique et la santé cellulaire." } }, { "@type": "Question", "name": "La thérapie génique est-elle une option ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "La thérapie génique est explorée pour corriger des déficiences enzymatiques spécifiques." } }, { "@type": "Question", "name": "Les médicaments anti-inflammatoires sont-ils utiles ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Oui, ils peuvent réduire l'inflammation causée par une dégradation protéique anormale." } }, { "@type": "Question", "name": "Comment la physiothérapie peut-elle aider ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "La physiothérapie peut améliorer la fonction musculaire et réduire la douleur associée." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec des troubles protéolytiques ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des maladies dégénératives, des troubles métaboliques et des infections peuvent survenir." } }, { "@type": "Question", "name": "Les complications cardiovasculaires sont-elles possibles ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des déséquilibres protéolytiques peuvent contribuer à des maladies cardiovasculaires." } }, { "@type": "Question", "name": "Comment les troubles protéolytiques affectent-ils le système immunitaire ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Ils peuvent affaiblir le système immunitaire, rendant l'organisme plus vulnérable aux infections." } }, { "@type": "Question", "name": "Y a-t-il un risque accru de cancer ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des anomalies dans la dégradation des protéines peuvent être liées à certains cancers." } }, { "@type": "Question", "name": "Les troubles neurologiques peuvent-ils s'aggraver ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles protéolytiques non traités peuvent aggraver les symptômes neurologiques." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque pour les troubles protéolytiques ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "L'âge avancé, des antécédents familiaux et des maladies métaboliques augmentent le risque." } }, { "@type": "Question", "name": "Le mode de vie influence-t-il ces risques ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, un mode de vie sédentaire et une mauvaise alimentation augmentent les risques." } }, { "@type": "Question", "name": "Les maladies auto-immunes sont-elles un facteur de risque ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, elles peuvent perturber la fonction des protéases et entraîner des complications." } }, { "@type": "Question", "name": "Le stress chronique est-il un facteur de risque ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut affecter la régulation des protéases et la santé globale." } }, { "@type": "Question", "name": "L'exposition à des toxines peut-elle augmenter le risque ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines toxines peuvent altérer la fonction des protéases et causer des dommages cellulaires." } } ] } ] }

Sources (2221 au total)

Epigenetic Regulation of IFI44L Expression in Monocytes Affects the Functions of Monocyte-Derived Dendritic Cells in Systemic Lupus Erythematosus.

Interferon-inducible 44 like (IFI44L) is a newly discovered interferon-induced gene and has been reported to overexpress in systemic lupus erythematosus (SLE). However, little is known about the mecha... We collected peripheral blood from 20 SLE patients and 20 healthy controls. Expression of IFI44L in monocytes and effects of different signal transducers and activators of transcription (STAT) pathway... Expression level of IFI44L was significantly increased in SLE monocyte. IFI44L expression was decreased most significantly in STAT3 inhibitor compared with other inhibitors. STAT3 regulated IFI44L exp... TET2 recruited by STAT3 induces DNA demethylation of IFI44L promoter which promotes IFI44L overexpression in monocyte contributing to the pathogenesis of SLE by enhancing the maturation and functions ...

Transient post-operative overexpression of CXCR2 on monocytes of traumatic brain injury patients drives monocyte chemotaxis toward cerebrospinal fluid and enhances monocyte-mediated immunogenic cell death of neurons in vitro.

After traumatic brain injury (TBI), peripheral monocytes infiltrate into the central nervous system due to disruption of the blood-brain barrier, and play an important role in neuroinflammation. Howev... TBI patients who underwent surgery at our hospital were recruited. CXCR2 expression in CD14... Transient CXCR2 upregulation in monocytes from the peripheral blood and CSF of TBI patients was detected soon after surgery and was associated with unfavorable outcomes. TBI serum and CSF promoted CXC... CXCR2 is transiently overexpressed in the peripheral monocytes of TBI patients post-surgery, and drives peripheral monocyte chemotaxis toward CSF and monocyte-mediated ICD of nerve cells. Therefore, C...

Monocyte-to-lymphocyte, neutrophil-to-lymphocyte and neutrophil-to-monocyte plus lymphocyte ratios in children with active tuberculosis: A multicentre study.

Higher number of monocytes and neutrophils may correlate with active tuberculosis (TB) in children. However, the few paediatric studies available are limited by the small numbers of children with TB d... We calculated the monocyte-to-lymphocyte-ratio (MLR), neutrophil-to-lymphocyte-ratio (NLR) and neutrophil-to-monocyte-plus-lymphocyte-ratio (NMLR) in children with active TB, latent TB infection (LTBI... Overall, 649 children were included (41.8% females, mean age of 5.74 years). MLR, NLR and NMLR values were always significantly higher in patients with TB compared with the other groups (p < 0.001). C... Our study provides further evidence that MLR, NLR and NMLR can serve as first level diagnostics to support the clinical suspicion of TB in children....

Papain ameliorates monocyte-platelet aggregate formation-mediated inflammatory responses in monocytes by upregulating miRNA-146a transcription.

MicroRNA-146a (miRNA-146a) is a nuclear factor κB (NF-κB)-inducible and inflammation-sensitive miRNA, while papain elicits anti-inflammatory effects by inhibiting monocyte-platelet aggregate (MPA)-med... THP-1 cells were exposed to papain, miRNA-146a mimic and inhibitor, NF-κB inhibitor (BAY11-7082), and platelets. Flow cytometry was used to measure the MPA formation-initiated monocyte activation. Lev... The NF-κB inhibitor and miRNA-146a mimics upregulated miRNA-146a expression but suppressed subsequent monocyte activation and expression of COX-2 and MCP-1. Following exposure to papain, the enhanced ... Our findings suggest that papain can inhibit MPA formation-mediated expression of inflammatory mediators in activated monocytes by upregulating miRNA-146a transcription....

Chronic Kidney Disease Is Characterized by Expansion of a Distinct Proinflammatory Intermediate Monocyte Subtype and by Increased Monocyte Adhesion to Endothelial Cells.

CKD is accompanied by abnormal inflammation, which contributes to progressive loss of functional renal tissue and accelerated cardiovascular disease. Although studies have documented that dysregulatio... Cardiovascular disease (CVD) in patients with CKD is associated with increased circulating intermediate monocytes (IMs). Dysregulation of monocyte maturation and function is associated with CKD and it... To explore monocyte repertoire abnormalities in CKD, we studied properties of monocyte subpopulations, including IM subpopulations distinguished by HLA-DR expression level, in individuals with or with... Of four predefined blood monocyte subpopulations, only HLA-DR hi IMs were increased in individuals with CKD compared with HVs and PCs. In HVs and patients with CKD, LPS-stimulated HLA-DR hi IMs isolat... CKD is associated with an increased number of a distinctive proinflammatory IM subpopulation and abnormalities of monocyte migration and endothelial adhesion. Dysregulated monocyte maturation and func...