questionsmedicales.fr
Phénomènes génétiques
Structures génétiques
Génome
Composants de génome
Gènes
Exons VDJ
Exons VDJ : Questions médicales fréquentes
Termes MeSH sélectionnés :
Single-Cell Gene Expression Analysis
Diagnostic
5
Séquençage de l'ADN
Anomalies génétiques
Imagerie médicale
Analyse moléculaire
Anticorps
Réarrangements génétiques
Tests génétiques
Fiabilité des tests
Symptômes
5
Infections
Troubles immunitaires
Anomalies génétiques
Symptômes
Troubles immunitaires
Symptômes
Symptômes
Troubles immunitaires
Prévention
5
Prévention
Anomalies génétiques
Mode de vie sain
Système immunitaire
Tests génétiques
Prévention
Conseils génétiques
Anomalies génétiques
Traitements
5
Thérapies immunosuppressives
Transfusions
Thérapie génique
Recherche
Médecine personnalisée
Anomalies génétiques
Complications
5
Infections
Troubles auto-immuns
Cancer
Anomalies génétiques
Complications
Gestion des maladies
Surveillance médicale
Complications
Qualité de vie
Complications
Facteurs de risque
5
Facteurs de risque
Antécédents familiaux
Infections virales
Facteurs de risque
Sexe
Anomalies génétiques
Facteurs environnementaux
Toxines
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"name": "Diagnostic",
"headline": "Diagnostic sur Exons VDJ",
"description": "Comment diagnostiquer une anomalie des exons VDJ ?\nQuels tests sont utilisés pour les exons VDJ ?\nLes exons VDJ peuvent-ils être détectés par imagerie ?\nQuels marqueurs indiquent des problèmes avec les exons VDJ ?\nLes tests génétiques sont-ils fiables pour les exons VDJ ?",
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"@type": "Question",
"name": "Comment diagnostiquer une anomalie des exons VDJ ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un diagnostic se fait par séquençage de l'ADN et analyse des réarrangements génétiques."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour les exons VDJ ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests PCR et le séquençage sont couramment utilisés pour évaluer les exons VDJ."
}
},
{
"@type": "Question",
"name": "Les exons VDJ peuvent-ils être détectés par imagerie ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, les exons VDJ nécessitent des analyses moléculaires, pas d'imagerie."
}
},
{
"@type": "Question",
"name": "Quels marqueurs indiquent des problèmes avec les exons VDJ ?",
"position": 4,
"acceptedAnswer": {
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"text": "Des niveaux anormaux d'anticorps ou des réarrangements génétiques peuvent indiquer des problèmes."
}
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"@type": "Question",
"name": "Les tests génétiques sont-ils fiables pour les exons VDJ ?",
"position": 5,
"acceptedAnswer": {
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"text": "Oui, les tests génétiques sont très fiables pour détecter les anomalies des exons VDJ."
}
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{
"@type": "Question",
"name": "Quels symptômes sont liés aux anomalies des exons VDJ ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les anomalies peuvent entraîner des infections fréquentes et des troubles immunitaires."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon le type d'anomalie VDJ ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent varier selon la nature et la gravité de l'anomalie."
}
},
{
"@type": "Question",
"name": "Les anomalies VDJ causent-elles des douleurs ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les anomalies VDJ ne causent généralement pas de douleurs, mais des infections peuvent en provoquer."
}
},
{
"@type": "Question",
"name": "Peut-on avoir des symptômes sans anomalie VDJ ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, d'autres troubles immunitaires peuvent provoquer des symptômes similaires sans anomalies VDJ."
}
},
{
"@type": "Question",
"name": "Les symptômes des anomalies VDJ sont-ils spécifiques ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, ils ne sont pas spécifiques et peuvent ressembler à d'autres troubles immunitaires."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les anomalies des exons VDJ ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il n'existe pas de méthode de prévention spécifique pour les anomalies des exons VDJ."
}
},
{
"@type": "Question",
"name": "Les vaccinations aident-elles à prévenir les complications ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les vaccinations peuvent aider à prévenir les infections chez les patients à risque."
}
},
{
"@type": "Question",
"name": "Un mode de vie sain peut-il réduire les risques ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Un mode de vie sain peut renforcer le système immunitaire, mais ne prévient pas les anomalies VDJ."
}
},
{
"@type": "Question",
"name": "Les tests génétiques peuvent-ils aider à la prévention ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les tests génétiques peuvent identifier les risques et permettre une surveillance précoce."
}
},
{
"@type": "Question",
"name": "Les conseils génétiques sont-ils utiles pour les familles ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les conseils génétiques peuvent aider les familles à comprendre les risques d'anomalies VDJ."
}
},
{
"@type": "Question",
"name": "Quels traitements existent pour les anomalies VDJ ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des thérapies immunosuppressives et des transfusions d'anticorps."
}
},
{
"@type": "Question",
"name": "La thérapie génique est-elle une option pour les anomalies VDJ ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "La thérapie génique est en recherche, mais pas encore une option standard pour ces anomalies."
}
},
{
"@type": "Question",
"name": "Les antibiotiques sont-ils efficaces contre les anomalies VDJ ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les antibiotiques ne traitent pas les anomalies VDJ, mais peuvent traiter les infections secondaires."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils personnalisés pour les anomalies VDJ ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être personnalisés selon le type et la gravité de l'anomalie."
}
},
{
"@type": "Question",
"name": "Les patients ont-ils besoin de suivi après traitement des anomalies VDJ ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un suivi régulier est essentiel pour surveiller les infections et l'immunité."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec les anomalies VDJ ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des infections récurrentes et des troubles auto-immuns."
}
},
{
"@type": "Question",
"name": "Les anomalies VDJ augmentent-elles le risque de cancer ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines anomalies VDJ peuvent augmenter le risque de développer des cancers hématologiques."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes."
}
},
{
"@type": "Question",
"name": "Les patients doivent-ils surveiller des signes de complications ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une surveillance régulière est cruciale pour détecter rapidement les complications."
}
},
{
"@type": "Question",
"name": "Les complications affectent-elles la qualité de vie ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les complications peuvent significativement affecter la qualité de vie des patients."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour les anomalies VDJ ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents familiaux et des expositions environnementales."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque d'anomalies VDJ ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines anomalies VDJ sont plus fréquentes chez les jeunes enfants et les adolescents."
}
},
{
"@type": "Question",
"name": "Les infections virales augmentent-elles le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines infections virales peuvent augmenter le risque d'anomalies VDJ."
}
},
{
"@type": "Question",
"name": "Le sexe joue-t-il un rôle dans les anomalies VDJ ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines anomalies peuvent être plus fréquentes chez un sexe que l'autre."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux influencent-ils les anomalies VDJ ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des toxines ou à des radiations peut augmenter le risque d'anomalies."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 11/04/2025
Contenu vérifié selon les dernières recommandations médicales
3 publications dans cette catégorie
Affiliations :
Department of Laboratory Medicine, Ningbo Medical Center Lihuili Hospital, Ningbo 315040, Zhejiang, China.
Publications dans "Exons VDJ" :
3 publications dans cette catégorie
Affiliations :
Department of Nephrology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, China.
Department of Dermatology, Peking University First Hospital, Beijing, China.
Publications dans "Exons VDJ" :
3 publications dans cette catégorie
Affiliations :
Department of Nephrology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, China.
Publications dans "Exons VDJ" :
3 publications dans cette catégorie
Affiliations :
Department of Nephrology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, China.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Villum Center for Bioanalytical Sciences, University of Southern Denmark, 5230 Odense M, Denmark.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Villum Center for Bioanalytical Sciences, University of Southern Denmark, 5230 Odense M, Denmark.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Villum Center for Bioanalytical Sciences, University of Southern Denmark, 5230 Odense M, Denmark.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Department of Biochemistry and Molecular Biology, University of Southern Denmark, 5230 Odense M, Denmark.
Villum Center for Bioanalytical Sciences, University of Southern Denmark, 5230 Odense M, Denmark.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Department of Nephrology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, China.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Department of Nephrology, The Affiliated Qingdao Municipal Hospital of Qingdao University, Qingdao, China.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Division of Medical Genetics, Department of Molecular Medicine, Sapienza University, San Camillo-Forlanini Hospital, Italy.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Burning Rock Biotech, Guangzhou, Guangdong 510300, P.R. China.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China.
International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of pharmacy, Jinan University, Guangzhou 510632, China.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China.
International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of pharmacy, Jinan University, Guangzhou 510632, China.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Institute of Genomic Medicine, College of Pharmacy, Jinan University, Guangzhou 510632, China.
International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), College of pharmacy, Jinan University, Guangzhou 510632, China.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Guangdong Provincial Key Laboratory of Stem Cell and Regenerative Medicine, Key Laboratory of Regenerative Biology, South China Institute for Stem Cell Biology and Regenerative Medicine, Guangzhou Institute of Biomedicine and Health, Chinese Academy of Sciences, Guangzhou 510530, China.
Publications dans "Exons VDJ" :
2 publications dans cette catégorie
Affiliations :
Department of Internal Medicine, Morsani College of Medicine, University of South Florida, 12901 Bruce B. Downs Blvd, MDC 19, Tampa, FL 33612, USA.
Publications dans "Exons VDJ" :
Single-cell (SC) gene expression analysis is crucial to dissect the complex cellular heterogeneity of solid tumors, which is one of the main obstacles for the development of effective cancer treatment...
scMuffin provides a series of functions to calculate qualitative and quantitative scores, such as: expression of marker sets for normal and tumor conditions, pathway activity, cell state trajectories,...
The analyses offered by scMuffin and the results achieved in the case study show that our tool helps addressing the main challenges in the bioinformatics analysis of SC expression data from solid tumo...
A common feature of single-cell RNA-seq (scRNA-seq) data is that the number of cells in a cell cluster may vary widely, ranging from a few dozen to several thousand. It is not clear whether scRNA-seq ...
We addressed this question by performing scRNA-seq and poly(A)-dependent bulk RNA-seq in comparable aliquots of human induced pluripotent stem cells-derived, purified vascular endothelial and smooth m...
Findings of the current study provide a quantitative reference for designing studies that aim for identifying DEGs for specific cell clusters using scRNA-seq data and for interpreting results of such ...
There is a wealth of software that utilizes single-cell RNA-seq (scRNA-seq) data to deconvolve spatial transcriptomic spots, which currently are not yet at single-cell resolution. Here we provide prot...
Normalization is a crucial step in the analysis of single-cell RNA-sequencing (scRNA-seq) counts data. Its principal objectives are reduction of systematic biases primarily introduced through technica...
The widely adopted bulk RNA-seq measures the gene expression average of cells, masking cell type heterogeneity, which confounds downstream analyses. Therefore, identifying the cellular composition and...
We propose a new deconvolution algorithm, DSSC, which infers cell type-specific gene expression and cell type proportions of heterogeneous samples simultaneously by leveraging gene-gene and sample-sam...
DSSC provides a practical and promising alternative to the experimental techniques to characterize cellular composition and heterogeneity in the gene expression of heterogeneous samples....
Cell clustering is a prerequisite for identifying differentially expressed genes (DEGs) in single-cell RNA sequencing (scRNA-seq) data. Obtaining a perfect clustering result is of central importance f...
Here, we propose single-cell minimum enclosing ball (scMEB), a novel and fast method for detecting single-cell DEGs without prior cell clustering results. The proposed method utilizes a small part of ...
We compared scMEB to two different approaches that could be used to identify DEGs without cell clustering. The investigation of 11 real datasets revealed that scMEB outperformed rival methods in terms...
The aim of this study was to reveal the key genes associated with macrophage polarization in liver cancer....
Data were downloaded from the Gene Expression Omnibus (GEO) and the Cancer Genome Atlas databases (TCGA). R package Seurat 4.0 was used to preprocess the downloaded single-cell sequencing data, princi...
Two thousand highly variable genes were obtained after the normalization of single-cell profiles. In all, 16 principal components and 15 cell clusters were obtained. Monocytes and macrophages were the...
The key genes associated with macrophage polarization, namely CD53, TGFBI, S100A4, pyruvate kinase M, LSP1, and SPP1, may be potential therapeutic targets for liver cancer....
As an essential regulator of type I interferon (IFN) response, TMEM173 participates in immune regulation and cell death induction. In recent studies, activation of TMEM173 has been regarded as a promi...
Quantitative real-time PCR (qRT-PCR) and western blotting (WB) were applied to determine the mRNA and protein levels of TMEM173 in peripheral blood mononuclear cells (PBMCs). TMEM173 mutation status w...
The mRNA and protein levels of TMEM173 were increased in PBMCs from B-ALL patients. Besides, frameshift mutation was presented in TMEM173 sequences of 2 B-ALL patients. ScRNA-seq analysis identified t...
Our findings provide insights into the transcriptomic features of TMEM173 in the BM of high-risk B-ALL patients. Targeted activation of TMEM173 in specific cells might provide new therapeutic strategi...
The poor prognosis of sepsis warrants the investigation of biomarkers for predicting the outcome. Several studies have indicated that PANoptosis exerts a critical role in tumor initiation and developm...
We obtained Sepsis samples and scRNA-seq data from the GEO database. PANoptosis-related genes were subjected to consensus clustering and functional enrichment analysis, followed by identification of d...
Unsupervised clustering analysis using 16 PANoptosis-related genes identified three subtypes of sepsis. Kaplan-Meier analysis showed significant differences in patient survival among the subtypes, wit...
We developed a machine learning based Boruta algorithm for profiling PANoptosis related subgroups with in predicting survival and clinical features in the sepsis....
Macrophages play an important role in the occurrence and development of atherosclerosis. However, few existing studies have deliberately analyzed the changes in characteristic genes in the process of ...
Carotid atherosclerotic plaque single-cell RNA (scRNA) sequencing data were analyzed to define the cells involved and determine their transcriptomic characteristics. KEGG enrichment analysis, CIBERSOR...
Nine cell clusters were identified. M1 macrophages, M2 macrophages, and M2/M1 macrophages were identified as three clusters within the macrophages. According to pseudotime analysis, M2/M1 macrophages ...
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