Comment diagnostiquer une déficience en convertases C3-C5 ?

Des tests sanguins mesurant les niveaux de C3 et C5 peuvent indiquer une déficience.

Quels tests sont utilisés pour évaluer l'activité du complément ?

Les tests d'hémolyse et les dosages de protéines du complément sont courants.

Quels signes cliniques suggèrent une activation du complément ?

Des symptômes comme des infections récurrentes ou des maladies auto-immunes peuvent indiquer une activation.

Peut-on mesurer l'activité des convertases dans le sang ?

Oui, des tests spécifiques peuvent évaluer l'activité des convertases dans le sérum.

Quels marqueurs biologiques sont associés aux convertases ?

Les niveaux de C3a et C5a, produits de clivage, sont des marqueurs importants.

Quels symptômes indiquent une activation excessive du complément ?

Des symptômes comme des éruptions cutanées, des douleurs articulaires et de la fièvre peuvent survenir.

Comment se manifestent les troubles liés aux convertases ?

Ils peuvent se manifester par des infections fréquentes et des réactions inflammatoires.

Les troubles du complément causent-ils des symptômes neurologiques ?

Oui, des troubles neurologiques peuvent survenir en raison d'une inflammation cérébrale.

Quels signes indiquent une déficience en C3 ?

Des infections bactériennes récurrentes et des maladies auto-immunes peuvent être des signes.

Les symptômes varient-ils selon le type de déficience ?

Oui, les symptômes peuvent varier selon que la déficience concerne C3 ou C5.

Peut-on prévenir les déficiences en complément ?

La prévention est difficile, mais un diagnostic précoce peut aider à gérer les symptômes.

Quelles mesures préventives peuvent réduire les infections ?

Des vaccinations et une bonne hygiène peuvent aider à réduire le risque d'infections.

Les patients doivent-ils éviter certains aliments ?

Il n'y a pas de restrictions alimentaires spécifiques, mais une alimentation équilibrée est conseillée.

Comment le suivi médical aide-t-il à prévenir les complications ?

Un suivi régulier permet d'identifier et de traiter rapidement les complications potentielles.

Les conseils génétiques sont-ils utiles pour les familles ?

Oui, les conseils génétiques peuvent aider à comprendre les risques de transmission.

Quels traitements sont disponibles pour les déficiences en complément ?

Les traitements incluent des immunoglobulines intraveineuses et des antibiotiques prophylactiques.

Comment traiter une activation excessive du complément ?

Des médicaments anti-inflammatoires et des inhibiteurs du complément peuvent être utilisés.

Les transfusions sanguines aident-elles en cas de déficience ?

Oui, les transfusions peuvent aider à restaurer les niveaux de protéines du complément.

Y a-t-il des thérapies géniques pour les déficiences en complément ?

Des recherches sont en cours sur les thérapies géniques pour traiter ces déficiences.

Les traitements sont-ils personnalisés selon le patient ?

Oui, les traitements sont souvent adaptés en fonction des besoins individuels du patient.

Quelles complications peuvent survenir avec une déficience en C3 ?

Des infections graves, des maladies auto-immunes et des complications rénales peuvent survenir.

Les complications sont-elles réversibles ?

Certaines complications peuvent être gérées, mais d'autres peuvent être permanentes.

Comment les complications affectent-elles la qualité de vie ?

Elles peuvent réduire la qualité de vie en entraînant des douleurs chroniques et des limitations fonctionnelles.

Les complications neurologiques sont-elles fréquentes ?

Oui, des complications neurologiques peuvent survenir, notamment des troubles cognitifs.

Quelles sont les complications liées à l'activation excessive du complément ?

Des complications comme des lésions tissulaires et des réactions inflammatoires peuvent se produire.

Quels facteurs augmentent le risque de déficience en complément ?

Des antécédents familiaux et certaines maladies auto-immunes augmentent le risque.

L'âge influence-t-il le risque de troubles du complément ?

Oui, le risque peut augmenter avec l'âge en raison de la dégradation du système immunitaire.

Les infections fréquentes sont-elles un facteur de risque ?

Oui, des infections fréquentes peuvent indiquer une déficience sous-jacente du complément.

Le sexe joue-t-il un rôle dans les troubles du complément ?

Oui, certaines déficiences sont plus fréquentes chez les femmes en raison de facteurs hormonaux.

Les maladies génétiques augmentent-elles le risque ?

Oui, certaines maladies génétiques peuvent prédisposer à des déficiences du complément.

Complement C3-C5 Convertases - Informations médicales vérifiées

Educational preferences in individuals with cardiometabolic disease differs with age, ethnicity and educational status.

12 2022

DOI: 10.1016/j.pec.2022.08.016 PMID: 36150978

To evaluate how sociodemographic factors influence educational modality preferences in people with cardiometabolic disease.... This was a cross-sectional study performed in people with diabetes and cardiovascular disease, who completed a questionnaire to denote their previous experience and ranked preferences for different ed... The questionnaire was completed by 3751 people, of whom 59% were men, median (interquartile range) age was 68 (59-76) years, and 78% were White European. In total, 73% had diabetes, 35% had heart dise... We highlight the importance of considering factors that could influence selection of educational modalities including age, ethnicity, gender and educational level. We anticipate this approach will aid... Given the influence of multiple demographic factors and previous experiences on expressed preferences, providers should support individuals to make informed decisions about educational interventions t...

Male Humans Aged Female Ethnicity +4 autres

Immigration Status, Educational Level, and Perceived Discrimination in Europe.

26 01 2023

DOI: 10.3390/ijerph20032222 PMID: 36767588

Multiple studies have been conducted to test the moderating effect of immigration on the positive health results yielded through educational attainment. However, no study has been conducted to examine... We aimed to study whether an inverse association exists between educational level and perceived discrimination in European countries and whether immigration status moderates the association between ed... Data from the 10th round of the cross-sectional European Social Survey (ESS) were used in this cross-sectional study. A total of 17,596 participants between 15-90 years old who lived in European count... Of 17,596 participants, 16,632 (94.5%) were native-born and 964 were immigrants (5.5%). We found that higher levels of educational level were protective against perceived discrimination, which was als... This study found that educational level was a protective factor against perceived discrimination. This effect, however, was more robust in the native-born participants than in their immigrant counterp...

Humans Adolescent Young Adult Adult Middle Aged +8 autres

Children oral health and parents education status: a cross sectional study.

24 10 2023

DOI: 10.1186/s12903-023-03424-x PMID: 37875845

Oral diseases are common and affect millions of people worldwide. They can range from mild and easily treatable conditions to more severe and serious diseases. Proper oral hygiene and regular dental m... We enrolled consecutively healthy subjects aged between 0-16 and their parents at the Dental Clinic of the University of Campania "L. Vanvitelli". The Italian version of the ECOHIS (I-ECOHIS) was admi... We found a significative association of a higher I-ECOHIS total score (coeff. 4.04244; CI 95%: 1.530855-6.554026; p = 0,002) and higher I-ECOHIS children section score (coeff. 3.2794; CI 95%: 1.29002-... Father unemployed status and a lower educational level for both parents may negatively affect oral health status....

Female Humans Child Infant, Newborn Infant +9 autres

Nature, Nurture, and the Meaning of Educational Attainment: Differences by Sex and Socioeconomic Status.

Feb 2023

DOI: 10.1017/thg.2023.6 PMID: 36912114

Estimated heritability of educational attainment (EA) varies widely, from 23% to 80%, with growing evidence suggesting the degree to which genetic variation contributes to individual differences in EA...

Female Humans Male Academic Success Educational Status +4 autres

The association between educational status and colorectal neoplasia: results from a screening cohort.

05 Apr 2023

DOI: 10.1007/s00384-023-04383-z PMID: 37017795

Educational status is used as a proxy for socioeconomic status. While lower levels of education are generally associated with poorer health, the data on the relationship between educational status and... We included 5977 participants undergoing a screening colonoscopy in Austria. We split the cohort into patients with lower (n = 2156), medium (n = 2933), and higher (n = 459) educational status. Multiv... We found that the rates of any neoplasia (32%) were similar between the educational strata. However, patients with higher (10%) educational status evidenced significantly higher rates of advanced colo... Our study found that higher educational status was associated with a higher prevalence of advanced colorectal neoplasia compared to medium and lower educational status. This finding remained significa...

Humans Colorectal Neoplasms Colonoscopy Educational Status Risk Factors +1 autres

Healthy and Respectful Relationship Education: Differences by Disability Status and Associations With Sexual Abuse.

07 2023

DOI: 10.1111/josh.13317 PMID: 36815452

Education about healthy and respectful relationships (HRR) is a key component of comprehensive sexual health curricula and is supposed to be universally provided in Oregon. This study: (1) assesses th... Using data from the 2019 Oregon Healthy Teens survey, we conducted multivariable Poisson regression to compare 11th grade students with and without disabilities on self-reported receipt of school base... Students with disabilities were 41% more likely than students without disabilities to say they had never been taught in school about HRR (adjusted prevalence ratio 1.41, 95% confidence interval: 1.25-... Students with disabilities are less likely to have received school-based HRR education than their peers without disabilities. Providing inclusive HRR education may help reduce risk of sexual abuse and...

Adolescent Humans Sex Offenses Health Status Schools +3 autres

Marital Status, Father Acknowledgement, and Birth Outcomes: Does the Maternal Education Matter?

10 03 2023

DOI: 10.3390/ijerph20064868 PMID: 36981777

We evaluated whether the maternal marital status and father acknowledgement (proxy for paternal presence) affect birth weight, and if so, whether the maternal educational attainment modifies this effe...

Female Humans Male Pregnancy Educational Status +5 autres

Health and health behaviours in adolescence as predictors of education and socioeconomic status in adulthood - a longitudinal study.

26 Apr 2024

DOI: 10.1186/s12889-024-18668-7 PMID: 38671433

The positive association of health with education level and socioeconomic status (SES) is well-established. Two theoretical frameworks have been delineated to understand main mechanisms leading to soc... Surveys on health and health behaviours were sent to representative samples of 12-18-year-old Finns in 1981-1997 every second year (response rate 77.8%, N = 55,682). The survey data were linked with t... In logistic regression analyses, good health, health-enhancing behaviours, and lack of health-compromising behaviours were related to higher education and SES, also after controlling for family backgr... Health and health behaviours in adolescence predicted education and SES in adulthood. Even though the relationships were modest, they support the health selection hypotheses and emphasise the importan...

Humans Adolescent Health Behavior Finland Male +8 autres

[Extremely preterm infants with severe intraventricular hemorrhage: neurological evolution and long term and educational status].

Apr 2024

DOI: 10.32641/andespediatr.v95i2.4604 PMID: 38801364

Extensive intraventricular hemorrhage (IVH) in very preterm newborns (VPNB) is associated with mortality and severe long-term neurological sequelae.... To know the most frequent neurological pathologies associated with extensive IVH, to determine the functional outcomes of mobility in the motor area and intellectual capacity in the cognitive area, to... Descriptive and longitudinal study in VPNB with extensive IVH born between 2001 and 2014. They underwent protocolized neurological follow-up until school age. The functional outcomes in mobility and i... 74 children completed the follow-up; the most frequent associated neurological pathologies were neurodevelopmental disorders, hypertensive hydrocephalus, and epilepsy. Independent mobility (normal or ... 2/3 VPNB with extensive IVH showed positive functional outcomes, from normal to mild limitations that allow an almost autonomous life; in 1/3 the outcomes were unfavorable in mobility and cognitive pe...

Humans Male Infant, Newborn Longitudinal Studies Female +12 autres

Educational impacts of the COVID-19 pandemic in the United States: Inequities by race, ethnicity, and socioeconomic status.

08 2023

DOI: 10.1016/j.copsyc.2023.101643 PMID: 37442079

The COVID-19 pandemic caused reverberations throughout the educational system that disproportionately impacted students of color and those from lower socioeconomic backgrounds. In this review, we exam...

Humans United States Ethnicity COVID-19 Pandemics +2 autres

Complement C3-C5 Convertases : Questions médicales fréquentes

Termes MeSH sélectionnés :

Questions fréquentes et termes MeSH associés

Diagnostic 5

Symptômes 5

Prévention 5

Traitements 5

Complications 5

Facteurs de risque 5

Contenu validé par Dr Olivier Menir

Sous-catégories

Alternative pathway C3-C5 Convertases

Classical pathway C3-C5 Convertases

Mannose-Binding Protein-Associated Serine Proteases

Alternative pathway complement C3 convertase

Alternative pathway C5 convertase

Classical pathway complement C3 convertase

Classical pathway C5 convertase

Auteurs principaux

Sources (10000 au total)