Titre : Syndécane-2

Syndécane-2 : Questions médicales fréquentes

Termes MeSH sélectionnés :

Clonidine
{ "@context": "https://schema.org", "@graph": [ { "@type": "MedicalWebPage", "name": "Syndécane-2 : Questions médicales les plus fréquentes", "headline": "Syndécane-2 : Comprendre les symptômes, diagnostics et traitements", "description": "Guide complet et accessible sur les Syndécane-2 : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.", "datePublished": "2024-02-14", "dateModified": "2025-05-09", "inLanguage": "fr", "medicalAudience": [ { "@type": "MedicalAudience", "name": "Grand public", "audienceType": "Patient", "healthCondition": { "@type": "MedicalCondition", "name": "Syndécane-2" }, "suggestedMinAge": 18, "suggestedGender": "unisex" }, { "@type": "MedicalAudience", "name": "Médecins", "audienceType": "Physician", "geographicArea": { "@type": "AdministrativeArea", "name": "France" } }, { "@type": "MedicalAudience", "name": "Chercheurs", "audienceType": "Researcher", "geographicArea": { "@type": "AdministrativeArea", "name": "International" } } ], "reviewedBy": { "@type": "Person", "name": "Dr Olivier Menir", "jobTitle": "Expert en Médecine", "description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale", "url": "/static/pages/docteur-olivier-menir.html", "alumniOf": { "@type": "EducationalOrganization", "name": "Université Paris Descartes" } }, "isPartOf": { "@type": "MedicalWebPage", "name": "Syndécanes", "url": "https://questionsmedicales.fr/mesh/D053667", "about": { "@type": "MedicalCondition", "name": "Syndécanes", "code": { "@type": "MedicalCode", "code": "D053667", "codingSystem": "MeSH" }, "identifier": { "@type": "PropertyValue", "propertyID": "MeSH Tree", "value": "D12.776.543.550.847" } } }, "about": { "@type": "MedicalCondition", "name": "Syndécane-2", "alternateName": "Syndecan-2", "code": { "@type": "MedicalCode", "code": "D053669", "codingSystem": "MeSH" } }, "author": [ { "@type": "Person", "name": "Eok-Soo Oh", "url": "https://questionsmedicales.fr/author/Eok-Soo%20Oh", "affiliation": { "@type": "Organization", "name": "Department of Life Sciences, College of Natural Sciences, Ewha Womans University, Seoul 03760, Korea." } }, { "@type": "Person", "name": "Anett Hudák", "url": "https://questionsmedicales.fr/author/Anett%20Hud%C3%A1k", "affiliation": { "@type": "Organization", "name": "Pharmacoidea Ltd., H-6726 Szeged, Hungary." } }, { "@type": "Person", "name": "Tamás Letoha", "url": "https://questionsmedicales.fr/author/Tam%C3%A1s%20Letoha", "affiliation": { "@type": "Organization", "name": "Pharmacoidea Ltd., H-6726 Szeged, Hungary." } }, { "@type": "Person", "name": "Bohee Jang", "url": "https://questionsmedicales.fr/author/Bohee%20Jang", "affiliation": { "@type": "Organization", "name": "Department of Life Sciences, College of Natural Sciences, Ewha Womans University, Seoul 03760, Korea." } }, { "@type": "Person", "name": "Annamária Letoha", "url": "https://questionsmedicales.fr/author/Annam%C3%A1ria%20Letoha", "affiliation": { "@type": "Organization", "name": "Department of Medicine, Albert Szent-Györgyi Clinical Center, Faculty of Medicine, University of Szeged, H-6725 Szeged, Hungary." } } ], "citation": [ { "@type": "ScholarlyArticle", "name": "Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial.", "datePublished": "2023-10-16", "url": "https://questionsmedicales.fr/article/37845651", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1186/s12902-023-01486-0" } }, { "@type": "ScholarlyArticle", "name": "Ropivacaine-Epinephrine-Clonidine-Ketorolac Cocktail as a Local Anesthetic for Lumbar Decompression Surgery: A Single Institutional Experience.", "datePublished": "2023-05-30", "url": "https://questionsmedicales.fr/article/37263493", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1016/j.wneu.2023.05.091" } }, { "@type": "ScholarlyArticle", "name": "Clonidine as analgesia during retinopathy of prematurity screening in preterm infants (cloROP): protocol for a randomised controlled trial.", "datePublished": "2022-09-22", "url": "https://questionsmedicales.fr/article/36137627", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1136/bmjopen-2022-064251" } }, { "@type": "ScholarlyArticle", "name": "Use of clonidine in the treatment of Irukandji syndrome: A 4-year retrospective cohort study on safety, efficacy and clinical utility.", "datePublished": "2022-05-31", "url": "https://questionsmedicales.fr/article/35638940", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1111/1742-6723.14017" } }, { "@type": "ScholarlyArticle", "name": "Postoperative recovery in preschool-aged children: A secondary analysis of a randomized controlled trial comparing premedication with midazolam, clonidine, and dexmedetomidine.", "datePublished": "2023-08-01", "url": "https://questionsmedicales.fr/article/37528645", "identifier": { "@type": "PropertyValue", "propertyID": "DOI", "value": "10.1111/pan.14740" } } ], "breadcrumb": { "@type": "BreadcrumbList", "itemListElement": [ { "@type": "ListItem", "position": 1, "name": "questionsmedicales.fr", "item": "https://questionsmedicales.fr" }, { "@type": "ListItem", "position": 2, "name": "Acides aminés, peptides et protéines", "item": "https://questionsmedicales.fr/mesh/D000602" }, { "@type": "ListItem", "position": 3, "name": "Protéines", "item": "https://questionsmedicales.fr/mesh/D011506" }, { "@type": "ListItem", "position": 4, "name": "Protéines membranaires", "item": "https://questionsmedicales.fr/mesh/D008565" }, { "@type": "ListItem", "position": 5, "name": "Glycoprotéines membranaires", "item": "https://questionsmedicales.fr/mesh/D008562" }, { "@type": "ListItem", "position": 6, "name": "Syndécanes", "item": "https://questionsmedicales.fr/mesh/D053667" }, { "@type": "ListItem", "position": 7, "name": "Syndécane-2", "item": "https://questionsmedicales.fr/mesh/D053669" } ] } }, { "@type": "MedicalWebPage", "name": "Article complet : Syndécane-2 - Questions et réponses", "headline": "Questions et réponses médicales fréquentes sur Syndécane-2", "description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.", "datePublished": "2025-05-17", "inLanguage": "fr", "hasPart": [ { "@type": "MedicalWebPage", "name": "Diagnostic", "headline": "Diagnostic sur Syndécane-2", "description": "Comment diagnostiquer une anomalie de Syndécane-2 ?\nQuels examens sont recommandés pour le Syndécane-2 ?\nLe dosage sanguin est-il utile pour le Syndécane-2 ?\nQuels marqueurs sont associés au Syndécane-2 ?\nY a-t-il des tests spécifiques pour le Syndécane-2 ?", "url": "https://questionsmedicales.fr/mesh/D053669?mesh_terms=Clonidine&page=2#section-diagnostic" }, { "@type": "MedicalWebPage", "name": "Symptômes", "headline": "Symptômes sur Syndécane-2", "description": "Quels symptômes sont liés à une dysfonction de Syndécane-2 ?\nLe Syndécane-2 affecte-t-il la croissance tumorale ?\nY a-t-il des signes cliniques associés au Syndécane-2 ?\nLe Syndécane-2 est-il lié à des maladies spécifiques ?\nComment le Syndécane-2 influence-t-il la signalisation cellulaire ?", "url": "https://questionsmedicales.fr/mesh/D053669?mesh_terms=Clonidine&page=2#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Syndécane-2", "description": "Peut-on prévenir les anomalies de Syndécane-2 ?\nY a-t-il des mesures préventives spécifiques ?\nL'alimentation influence-t-elle le Syndécane-2 ?\nLe tabagisme affecte-t-il le Syndécane-2 ?\nL'exercice physique a-t-il un impact sur le Syndécane-2 ?", "url": "https://questionsmedicales.fr/mesh/D053669?mesh_terms=Clonidine&page=2#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Syndécane-2", "description": "Quels traitements ciblent le Syndécane-2 ?\nLe Syndécane-2 peut-il être une cible thérapeutique ?\nY a-t-il des médicaments associés au Syndécane-2 ?\nComment les thérapies géniques affectent-elles le Syndécane-2 ?\nLe Syndécane-2 est-il impliqué dans des essais cliniques ?", "url": "https://questionsmedicales.fr/mesh/D053669?mesh_terms=Clonidine&page=2#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Syndécane-2", "description": "Quelles complications peuvent survenir avec le Syndécane-2 ?\nLe Syndécane-2 est-il lié à des complications cardiovasculaires ?\nComment le Syndécane-2 affecte-t-il la réponse immunitaire ?\nY a-t-il des complications liées à la thérapie ciblée du Syndécane-2 ?\nLe Syndécane-2 influence-t-il la progression des maladies ?", "url": "https://questionsmedicales.fr/mesh/D053669?mesh_terms=Clonidine&page=2#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Syndécane-2", "description": "Quels sont les facteurs de risque pour le Syndécane-2 ?\nL'âge influence-t-il le Syndécane-2 ?\nLe stress a-t-il un impact sur le Syndécane-2 ?\nY a-t-il des prédispositions génétiques au Syndécane-2 ?\nL'environnement joue-t-il un rôle dans le Syndécane-2 ?", "url": "https://questionsmedicales.fr/mesh/D053669?mesh_terms=Clonidine&page=2#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une anomalie de Syndécane-2 ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques et des analyses de tissus peuvent être utilisés pour évaluer les niveaux de Syndécane-2." } }, { "@type": "Question", "name": "Quels examens sont recommandés pour le Syndécane-2 ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Des biopsies et des analyses immunohistochimiques peuvent aider à diagnostiquer les anomalies." } }, { "@type": "Question", "name": "Le dosage sanguin est-il utile pour le Syndécane-2 ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Le dosage sanguin peut fournir des informations sur les niveaux de Syndécane-2 dans certaines conditions." } }, { "@type": "Question", "name": "Quels marqueurs sont associés au Syndécane-2 ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Des marqueurs tumoraux et des cytokines peuvent être associés à l'expression de Syndécane-2." } }, { "@type": "Question", "name": "Y a-t-il des tests spécifiques pour le Syndécane-2 ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Des tests spécifiques d'immunofluorescence peuvent être utilisés pour détecter Syndécane-2." } }, { "@type": "Question", "name": "Quels symptômes sont liés à une dysfonction de Syndécane-2 ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes peuvent inclure des troubles de l'adhésion cellulaire et des anomalies tissulaires." } }, { "@type": "Question", "name": "Le Syndécane-2 affecte-t-il la croissance tumorale ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une expression anormale de Syndécane-2 peut influencer la croissance et la métastase tumorale." } }, { "@type": "Question", "name": "Y a-t-il des signes cliniques associés au Syndécane-2 ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Des signes cliniques peuvent inclure des inflammations et des modifications dans la matrice extracellulaire." } }, { "@type": "Question", "name": "Le Syndécane-2 est-il lié à des maladies spécifiques ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Oui, il est impliqué dans des maladies comme le cancer et certaines maladies inflammatoires." } }, { "@type": "Question", "name": "Comment le Syndécane-2 influence-t-il la signalisation cellulaire ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Il modifie la signalisation cellulaire en interagissant avec des récepteurs et des ligands." } }, { "@type": "Question", "name": "Peut-on prévenir les anomalies de Syndécane-2 ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "La prévention passe par un mode de vie sain et la réduction des facteurs de risque associés." } }, { "@type": "Question", "name": "Y a-t-il des mesures préventives spécifiques ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Des dépistages réguliers et une surveillance des maladies associées peuvent aider à la prévention." } }, { "@type": "Question", "name": "L'alimentation influence-t-elle le Syndécane-2 ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée peut influencer l'expression de Syndécane-2 et la santé cellulaire." } }, { "@type": "Question", "name": "Le tabagisme affecte-t-il le Syndécane-2 ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le tabagisme peut altérer l'expression de Syndécane-2 et augmenter le risque de maladies." } }, { "@type": "Question", "name": "L'exercice physique a-t-il un impact sur le Syndécane-2 ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "L'exercice régulier peut améliorer la santé cellulaire et potentiellement réguler Syndécane-2." } }, { "@type": "Question", "name": "Quels traitements ciblent le Syndécane-2 ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Des thérapies ciblées et des anticorps monoclonaux peuvent être développés pour cibler Syndécane-2." } }, { "@type": "Question", "name": "Le Syndécane-2 peut-il être une cible thérapeutique ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, en raison de son rôle dans la progression tumorale, il est une cible potentielle pour des traitements." } }, { "@type": "Question", "name": "Y a-t-il des médicaments associés au Syndécane-2 ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Des médicaments expérimentaux ciblant la signalisation de Syndécane-2 sont en développement." } }, { "@type": "Question", "name": "Comment les thérapies géniques affectent-elles le Syndécane-2 ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Les thérapies géniques peuvent corriger les anomalies d'expression de Syndécane-2 dans certaines pathologies." } }, { "@type": "Question", "name": "Le Syndécane-2 est-il impliqué dans des essais cliniques ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des essais cliniques évaluent des traitements ciblant Syndécane-2 dans divers cancers." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec le Syndécane-2 ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications incluent des troubles de la cicatrisation et des métastases dans le cancer." } }, { "@type": "Question", "name": "Le Syndécane-2 est-il lié à des complications cardiovasculaires ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des études suggèrent un lien entre Syndécane-2 et des complications cardiovasculaires." } }, { "@type": "Question", "name": "Comment le Syndécane-2 affecte-t-il la réponse immunitaire ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "Une dysfonction de Syndécane-2 peut altérer la réponse immunitaire, augmentant le risque d'infections." } }, { "@type": "Question", "name": "Y a-t-il des complications liées à la thérapie ciblée du Syndécane-2 ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Des effets secondaires peuvent survenir avec les thérapies ciblées, nécessitant une surveillance." } }, { "@type": "Question", "name": "Le Syndécane-2 influence-t-il la progression des maladies ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une expression anormale peut accélérer la progression de certaines maladies, comme le cancer." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque pour le Syndécane-2 ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent des prédispositions génétiques, le tabagisme et l'obésité." } }, { "@type": "Question", "name": "L'âge influence-t-il le Syndécane-2 ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'âge peut affecter l'expression de Syndécane-2 et le risque de maladies associées." } }, { "@type": "Question", "name": "Le stress a-t-il un impact sur le Syndécane-2 ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Le stress chronique peut influencer l'expression de Syndécane-2 et la santé cellulaire." } }, { "@type": "Question", "name": "Y a-t-il des prédispositions génétiques au Syndécane-2 ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, certaines mutations génétiques peuvent augmenter le risque d'anomalies de Syndécane-2." } }, { "@type": "Question", "name": "L'environnement joue-t-il un rôle dans le Syndécane-2 ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à des toxines environnementales peut affecter l'expression de Syndécane-2." } } ] } ] }

Sources (122 au total)

Effectiveness of oral clonidine and gabapentin on peripheral neuropathy in diabetic patients in southwestern Iran: a randomized clinical trial.

Peripheral neuropathy is not only the most prevalent consequence of diabetes but also the main reason for foot ulceration, disability, and amputation. Therefore, the current study aims to determine th... This 12-week, randomized, and parallel-group trial was conducted to compare the efficacy of oral clonidine and gabapentin with gabapentin alone in diabetic patients in southwest Iran during the first ... The mean and standard deviation of the age of the participants in the clonidine + gabapentin group was equal to 50.20 ± 7.44, and in the gabapentin group was equal to 50.47 ± 7.57 (t = 0.10, P-value =... According to this research results, clonidine + gabapentin can reduce neuropathic pain and the severity of neuropathic pain in diabetic patients. Therefore, it is recommended that healthcare professio... This study was registered in the Iranian Clinical Trials System with the ID (IRCT20211106052983N1) on 14/01/2022....

Ropivacaine-Epinephrine-Clonidine-Ketorolac Cocktail as a Local Anesthetic for Lumbar Decompression Surgery: A Single Institutional Experience.

The goal of this study is to discuss our initial experience with a multimodal opioid-sparing cocktail containing ropivacaine, epinephrine, clonidine, and ketorolac (RECK) in the postoperative manageme... Patients were either administered no local anesthetic at the incision site or were administered a weight-based amount of RECK into the paraspinal musculature and subdermal space surrounding the operat... A total of 121 patients undergoing 52 lumbar laminectomy and 69 lumbar diskectomy surgeries were identified. For lumbar laminectomy, patients who were administered RECK had decreased opioid use in the... The RECK cocktail has potential to be an effective therapeutic option for the postoperative management of lumbar decompression surgeries....

Clonidine as analgesia during retinopathy of prematurity screening in preterm infants (cloROP): protocol for a randomised controlled trial.

Preterm infants are at risk of negative consequences from stress and pain at the same time as they often are in need of intensive care that includes painful interventions. One of the frequent painful ... The planned study is a multicentre randomised controlled trial with a crossover design. Infants will be recruited from two different neonatal intensive care units (NICUs) in Sweden. Infants born befor... Approval from the Swedish Ethical Review Authority and the Swedish Medical Products Agency has been obtained for the study. Parents of eligible infants will be getting both verbal and written informat... ClinicalTrials.gov (NCT04902859).EudraCT (2021-003005-21)....

Use of clonidine in the treatment of Irukandji syndrome: A 4-year retrospective cohort study on safety, efficacy and clinical utility.

Irukandji syndrome (IS) is an extremely painful condition that causes a significant catecholamine surge and sympathetic autonomic response related to the envenomation from certain types of jellyfish. ... All patients diagnosed with IS at Cairns Hospital between 1 March 2016 and 30 April 2020, and participants from the Magnesium in Irukandji Study Trial, were included in this retrospective study (n = 1... Notably, 39 patients with IS received ≥1 mcg/kg clonidine and the remaining 75 did not. There was no difference in oral morphine equivalent daily dose (oMEDD) between groups before clonidine administr... Patients with IS who received clonidine required significantly lower opioid requirements than those who did not receive clonidine. Clonidine was safe to administer and should be considered early when ...

Postoperative recovery in preschool-aged children: A secondary analysis of a randomized controlled trial comparing premedication with midazolam, clonidine, and dexmedetomidine.

Preoperative anxiety in pediatric patients can worsen postoperative outcomes and delay discharge. Drugs aimed at reducing preoperative anxiety and facilitating postoperative recovery are available; ho... In this prespecified secondary analysis of a double-blinded randomized trial, 90 children scheduled for ear, nose, and throat surgery were randomized (1:1:1) to receive sedative premedication: oral mi... After excluding eight children due to drug refusal or deviation from the protocol, 82 children were included in this study. No differences were found between the groups in terms of median time [interq... No statistical difference was observed in the postoperative recovery times between the premedication regimens. Compared with midazolam, dexmedetomidine was favorable in reducing both emergence deliriu...

Efficacy and safety of epidural clonidine by continuous infusion or patient-controlled analgesia in labor: A meta-analysis of randomized controlled trials.

Epidural clonidine improves analgesia but may induce adverse effects in labor.... To evaluate the efficacy and safety of epidural clonidine as local anesthetics (LA) adjuvant by continuous infusion or patient-controlled epidural analgesia (PCEA) in labor.... PubMed, Embase, Web of Science, and CENTRAL were searched from inception to May 10, 2022 without language restriction; references of the retrieved studies were hand searched.... Randomized controlled trials (RCTs) comparing epidural LA with and without clonidine using continuous infusion or PCEA in labor were included.... A random effects model was used to pool the data on analgesia and adverse effects.... Eight RCTs were included. Clonidine did not reduce the incidence of parturients requiring additional epidural boluses but reduced LA consumption and pain scores without increasing adverse effects, exc... Epidural clonidine by continuous infusion or PCEA does not increase significant adverse effects and offers similar analgesia to opioids in labor. PROSPERO registration no. CRD42022306565....

Growth hormone responses during arginine and clonidine stimulation test: Correlations with patients' auxological and metabolic parameters in a single centre study.

Children with auxological parameters defining a 'short stature' is routinely subjected to various blood tests and, if necessary, to growth hormone stimulation test (GHST) for differentiating GH defici... This retrospective monocentric study aimed to evaluate any correlations between GH peaks during GHST in children assessed for short stature and their auxological/metabolic parameters, highlighting dif... We reviewed the medical records of 74 children with short stature (height lower than the third percentile according to standardized growth curves for the Italian population) managed at the Pediatric D... We found significantly lower serum levels of insulin growth factor-1 (IGF-1) and increased levels of thyroid-stimulating hormone (TSH) in children with GHD, without other metabolic differences in comp...

Efficacy and safety of clonidine for the treatment of impulse control disorder in Parkinson's disease: a multicenter, parallel, randomised, double-blind, Phase 2b Clinical trial.

Impulse control disorders (ICDs) are frequently encountered in Parkinson's disease (PD).... We aimed to assess whether clonidine, an α2-adrenergic receptor agonist, would improve ICDs.... We conducted a multicentre trial in five movement disorder departments. Patients with PD and ICDs (n = 41) were enrolled in an 8-week, randomised (1:1), double-blind, placebo-controlled study of cloni... Between 15 May 2019 and 10 September 2021, 19 patients in the clonidine group and 20 patients in the placebo group were enrolled. The proportion difference of success in reducing QUIP-RS at 8 weeks, w... Clonidine was well tolerated but our study was not enough powerful to demonstrate significant superiority compared to placebo in reducing ICDs despite a greater reduction of total QUIP score at 8 week... The study was registered (NCT03552068) on clinicaltrials.gov on June 11, 2018....

Identification of a Conversion Factor for Dexmedetomidine to Clonidine Transitions.

To determine a conversion factor for use when switching from dexmedetomidine infusion to enteral clonidine in critically ill neonates.... This was an observational, retrospective review of conversions from dexmedetomidine to -clonidine, performed in a neonatal intensive care unit (NICU) between January 2020 and December 2021. Both initi... A total of 43 dexmedetomidine to clonidine conversions were included. The median (IQR) dexmedetomidine dose prior to conversion was 17.4 (11.3-24.0) mcg/kg/day (0.7 mcg/kg/hr) and the median (IQR) ent... Neonatal clinicians may find the conversion factor identified in this study a useful starting point when converting from dexmedetomidine infusion to enteral clonidine in practice and should be -remind...

Effectiveness of Clonidine in Child and Adolescent Sleep Disorders.

We aimed to investigate the improvement in sleep quantity and quality when clonidine was used in children and adolescents with insomnia. We also examined how sociodemographic characteristics such as a... We retrospectively reviewed outpatients aged 6 to 24 who took clonidine due to insomnia from September 2019 to September 2021 at the Department of Psychiatry at Eunpyeong St. Mary's Hospital of Cathol... A total of 62 participants were included in our study (34 females, mean age 13.94±4.94 years). After using clonidine, there was a significant decrease in PSQI components 1, 2, and 5, especially PSQI c... Considering that there are currently no Food and Drug Administration-approved sleep drugs for children and adolescents and no apparent difference in efficacy and safety among sleep drugs, we demonstra...