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"name": "Diagnostic",
"headline": "Diagnostic sur Syndécane-2",
"description": "Comment diagnostiquer une anomalie de Syndécane-2 ?\nQuels examens sont recommandés pour le Syndécane-2 ?\nLe dosage sanguin est-il utile pour le Syndécane-2 ?\nQuels marqueurs sont associés au Syndécane-2 ?\nY a-t-il des tests spécifiques pour le Syndécane-2 ?",
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"description": "Quels symptômes sont liés à une dysfonction de Syndécane-2 ?\nLe Syndécane-2 affecte-t-il la croissance tumorale ?\nY a-t-il des signes cliniques associés au Syndécane-2 ?\nLe Syndécane-2 est-il lié à des maladies spécifiques ?\nComment le Syndécane-2 influence-t-il la signalisation cellulaire ?",
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"description": "Peut-on prévenir les anomalies de Syndécane-2 ?\nY a-t-il des mesures préventives spécifiques ?\nL'alimentation influence-t-elle le Syndécane-2 ?\nLe tabagisme affecte-t-il le Syndécane-2 ?\nL'exercice physique a-t-il un impact sur le Syndécane-2 ?",
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"description": "Quels traitements ciblent le Syndécane-2 ?\nLe Syndécane-2 peut-il être une cible thérapeutique ?\nY a-t-il des médicaments associés au Syndécane-2 ?\nComment les thérapies géniques affectent-elles le Syndécane-2 ?\nLe Syndécane-2 est-il impliqué dans des essais cliniques ?",
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"headline": "Complications sur Syndécane-2",
"description": "Quelles complications peuvent survenir avec le Syndécane-2 ?\nLe Syndécane-2 est-il lié à des complications cardiovasculaires ?\nComment le Syndécane-2 affecte-t-il la réponse immunitaire ?\nY a-t-il des complications liées à la thérapie ciblée du Syndécane-2 ?\nLe Syndécane-2 influence-t-il la progression des maladies ?",
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"headline": "Facteurs de risque sur Syndécane-2",
"description": "Quels sont les facteurs de risque pour le Syndécane-2 ?\nL'âge influence-t-il le Syndécane-2 ?\nLe stress a-t-il un impact sur le Syndécane-2 ?\nY a-t-il des prédispositions génétiques au Syndécane-2 ?\nL'environnement joue-t-il un rôle dans le Syndécane-2 ?",
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"@type": "Question",
"name": "Comment diagnostiquer une anomalie de Syndécane-2 ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques et des analyses de tissus peuvent être utilisés pour évaluer les niveaux de Syndécane-2."
}
},
{
"@type": "Question",
"name": "Quels examens sont recommandés pour le Syndécane-2 ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des biopsies et des analyses immunohistochimiques peuvent aider à diagnostiquer les anomalies."
}
},
{
"@type": "Question",
"name": "Le dosage sanguin est-il utile pour le Syndécane-2 ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le dosage sanguin peut fournir des informations sur les niveaux de Syndécane-2 dans certaines conditions."
}
},
{
"@type": "Question",
"name": "Quels marqueurs sont associés au Syndécane-2 ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des marqueurs tumoraux et des cytokines peuvent être associés à l'expression de Syndécane-2."
}
},
{
"@type": "Question",
"name": "Y a-t-il des tests spécifiques pour le Syndécane-2 ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests spécifiques d'immunofluorescence peuvent être utilisés pour détecter Syndécane-2."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont liés à une dysfonction de Syndécane-2 ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes peuvent inclure des troubles de l'adhésion cellulaire et des anomalies tissulaires."
}
},
{
"@type": "Question",
"name": "Le Syndécane-2 affecte-t-il la croissance tumorale ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une expression anormale de Syndécane-2 peut influencer la croissance et la métastase tumorale."
}
},
{
"@type": "Question",
"name": "Y a-t-il des signes cliniques associés au Syndécane-2 ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des signes cliniques peuvent inclure des inflammations et des modifications dans la matrice extracellulaire."
}
},
{
"@type": "Question",
"name": "Le Syndécane-2 est-il lié à des maladies spécifiques ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, il est impliqué dans des maladies comme le cancer et certaines maladies inflammatoires."
}
},
{
"@type": "Question",
"name": "Comment le Syndécane-2 influence-t-il la signalisation cellulaire ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Il modifie la signalisation cellulaire en interagissant avec des récepteurs et des ligands."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les anomalies de Syndécane-2 ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention passe par un mode de vie sain et la réduction des facteurs de risque associés."
}
},
{
"@type": "Question",
"name": "Y a-t-il des mesures préventives spécifiques ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des dépistages réguliers et une surveillance des maladies associées peuvent aider à la prévention."
}
},
{
"@type": "Question",
"name": "L'alimentation influence-t-elle le Syndécane-2 ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut influencer l'expression de Syndécane-2 et la santé cellulaire."
}
},
{
"@type": "Question",
"name": "Le tabagisme affecte-t-il le Syndécane-2 ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le tabagisme peut altérer l'expression de Syndécane-2 et augmenter le risque de maladies."
}
},
{
"@type": "Question",
"name": "L'exercice physique a-t-il un impact sur le Syndécane-2 ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'exercice régulier peut améliorer la santé cellulaire et potentiellement réguler Syndécane-2."
}
},
{
"@type": "Question",
"name": "Quels traitements ciblent le Syndécane-2 ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des thérapies ciblées et des anticorps monoclonaux peuvent être développés pour cibler Syndécane-2."
}
},
{
"@type": "Question",
"name": "Le Syndécane-2 peut-il être une cible thérapeutique ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, en raison de son rôle dans la progression tumorale, il est une cible potentielle pour des traitements."
}
},
{
"@type": "Question",
"name": "Y a-t-il des médicaments associés au Syndécane-2 ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments expérimentaux ciblant la signalisation de Syndécane-2 sont en développement."
}
},
{
"@type": "Question",
"name": "Comment les thérapies géniques affectent-elles le Syndécane-2 ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les thérapies géniques peuvent corriger les anomalies d'expression de Syndécane-2 dans certaines pathologies."
}
},
{
"@type": "Question",
"name": "Le Syndécane-2 est-il impliqué dans des essais cliniques ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des essais cliniques évaluent des traitements ciblant Syndécane-2 dans divers cancers."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec le Syndécane-2 ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des troubles de la cicatrisation et des métastases dans le cancer."
}
},
{
"@type": "Question",
"name": "Le Syndécane-2 est-il lié à des complications cardiovasculaires ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des études suggèrent un lien entre Syndécane-2 et des complications cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Comment le Syndécane-2 affecte-t-il la réponse immunitaire ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une dysfonction de Syndécane-2 peut altérer la réponse immunitaire, augmentant le risque d'infections."
}
},
{
"@type": "Question",
"name": "Y a-t-il des complications liées à la thérapie ciblée du Syndécane-2 ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des effets secondaires peuvent survenir avec les thérapies ciblées, nécessitant une surveillance."
}
},
{
"@type": "Question",
"name": "Le Syndécane-2 influence-t-il la progression des maladies ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une expression anormale peut accélérer la progression de certaines maladies, comme le cancer."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour le Syndécane-2 ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des prédispositions génétiques, le tabagisme et l'obésité."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le Syndécane-2 ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'âge peut affecter l'expression de Syndécane-2 et le risque de maladies associées."
}
},
{
"@type": "Question",
"name": "Le stress a-t-il un impact sur le Syndécane-2 ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress chronique peut influencer l'expression de Syndécane-2 et la santé cellulaire."
}
},
{
"@type": "Question",
"name": "Y a-t-il des prédispositions génétiques au Syndécane-2 ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines mutations génétiques peuvent augmenter le risque d'anomalies de Syndécane-2."
}
},
{
"@type": "Question",
"name": "L'environnement joue-t-il un rôle dans le Syndécane-2 ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à des toxines environnementales peut affecter l'expression de Syndécane-2."
}
}
]
}
]
}
Assessment of motor and cognitive functions is recommended before clean intermittent catheterization training. Two validated instruments, the Functional Independence Measure (FIM) and the Pencil and P...
We aimed to compare the performance of these tools in predicting the outcome of clean intermittent catheterization training in multiple sclerosis....
All people with multiple sclerosis attending a tertiary neuro-urology department between 2011 and 2019 and eligible for clean intermittent catheterization were included in this retrospective study. Th...
We included 395 individuals (mean [SD] age 49.8 [12] years; 70% women). At the end of the session, 87% of the patients succeeded in learning self-catheterization. The optimal cut-offs for the FIM (107...
An FIM value ≥107 has the best specificity to predict outcome after clean intermittent catheterization training for people with multiple sclerosis. The sensitivity of the FIM and PP-Test is similar, a...
Neurogenic bladder dysfunction is a major problem for spinal cord injury (SCI) patients not only due to the risk of serious complications but also because of the impact on quality of life. The main ai...
This was a retrospective cohort study from 2005 to 2020 including adult male or female patients who have an SCI at least more than 1 month ago with neurogenic bladder dysfunction and were using interm...
A total of 1000 patients were selected and recruited through a stratified random sampling technique with 467 (47.60%) patients in the uncoated catheter arm and 524 (52.60%) in the coated catheter grou...
The results indicate a beneficial effect regarding clinical UTI when using hydrophilic-coated catheters in terms of fewer cases of symptomatic UTI. Bacteriuria is inevitable in patients with long-term...
Intermittent self-catheterization (ISC) is widely considered the gold standard for treating patients with neurogenic bladder (NB). Healthcare professionals and catheter users must optimize ISC care to...
The objective of this study was to culturally adapt the ISC-Q and develop the Chinese version of the ISC-Q (C-ISC-Q), and assess its reliability and validity among patients with NB....
With the authorization of the ISC-Q author, the Beaton mode was used to adapt the scale cross-culturally. The study was conducted from June 2020 to June 2021 in three phases: committee-based translati...
The C-ISC-Q has 24 items and four dimensions. The critical ratio of each item is over 3.0, and the correlation coefficient between each item and the scale's total score is above 0.4. The Cronbach's α ...
The C-ISC-Q is culturally sensitive, reliable, and valid to measure the quality of life for patients with NB. It can assist nurses and researchers in tailoring strategies to enhance the quality of lif...
Clean intermittent catheterization (CIC) is associated with an increased risk of urinary tract infections (UTI), urethral trauma, urethral stenosis, hematuria, and pain. The first catheters were devel...
To conduct a systematic review and meta-analysis to evaluate the effectiveness of hydrophilic coated catheters compared to uncoated catheters on the rate of UTI in patients using CIC....
A systematic literature search was performed in OVID, Embase, Scopus, Web of Science, PubMed, and CENTRAL databases. Randomized controlled trials (RCTs) or randomized crossover trials comparing UTI an...
Nine studies with a total of 525 patients in CIC were analyzed. Overall, the use of hydrophilic catheters had a lower risk of UTIs compared to uncoated catheters (RR = 0.78; 95% CI 0.62-0.97; I...
We found a risk reduction of UTIs associated with using hydrophilic catheters in adults, with low heterogeneity. Regarding hematuria, significant differences were not proved. We do not find a signific...
To identify the clinical and urodynamic risk factors associated with the development of recurrent febrile urinary tract infections (FUTIs) in children with neurogenic bladder (NB) who perform clean in...
Children with NB receiving CIC were prospectively enrolled from January to December 2019 and followed up prospectively for 2 years. All data were compared between occasional (0-1 FUTI) and recurrent F...
Complete data from 321 children were analyzed. Occasional FUTIs occurred in 223 patients, and 98 patients experienced recurrent FUTIs. Univariate and multivariate analyses, showed late-initiation and ...
Our study suggests that late-initiation and low-frequency CIC, VUR, small bladder capacity and low compliance, and detrusor overactivity were associated with recurrent FUTIs in patients with NB. In ad...
In April 2008, Medicare amended its policy for clean intermittent catheterization, increasing coverage from 4 reused catheters per month to up to 200 single-use catheters. The primary reason for the p...
We accessed data for the years 1995 to 2020 from the National Spinal Cord Injury Database focusing on 1-year follow-up in those unable to volitionally void after injury. We asked 2 questions: (1) Did ...
During the study period, 2,657 of the 6,843 (38.8%) participants unable to volitionally void after spinal cord injury were hospitalized during their first follow-up year. Of the cohort performing clea...
Our findings suggest the 2008 policy change shifting clean intermittent catheterization coverage from catheter reuse to single-use did not decrease hospitalizations for urinary tract infection or incr...
Urinary diversions after radical cystectomy (RC) have a significant impact on quality of life and body image. Particularly for orthotopic neobladder (ONB), the rate of continence, urinary retention an...
In this prospective randomized study patients were divided in two groups. Patients were on a standard postoperative care (group A) or started CIC within the first postoperative month (group B). All pa...
Thirty-nine male and 8 female patients underwent laparoscopic or robotic RC with intracorporeal ONB (37 U shaped and 10 Padua reconstructions). At the first follow up, mean PVR was in group A and B, 1...
Our data support the early introduction of self CIC in patients with ONB after RC. The CIC was significantly associated a reduced risk of incontinence, urinary retention, and UTI with significant impr...
Clean intermittent catheterization (CIC) is a well-established method of managing lower urinary tract dysfunction. Depending on the age at introduction, caregivers might perform CIC initially but then...
A phenomenological approach was used to gather information from caregivers and children >12 years through semistructured interviews. Thematic analysis was utilized to generate themes around experience...
Of the 40 families interviewed, 25 families underwent successful transition to patient self-CIC. Analysis of excerpts identified a three-step process, including (1) desiring to learn self-CIC, (2) pra...
Authors reviewed interventions to address challenges and provide clinical care recommendations to enhance success during the transition to patient self-CIC....
No prior studies have identified this stepwise process that occurs in the transition from caregiver-led CIC to patient self-CIC. Healthcare providers and school officials (where indicated) can support...
This retrospective study evaluated the safety and efficacy of fluoroscopy-guided urethral catheterization in patients who failed blind or cystoscopy-assisted urethral catheterization. We utilized our ...
To summarize available data focused on diagnosis and management of urethral stricture in men with neurogenic lower urinary tract dysfunction by a systematic review of the literature....
A systematic review of the literature was carried out through an extensive electronic database search performed in PubMed/MEDLINE and Scopus databases for full texts, and International Continence Soci...
A total of 316 articles were identified, 48 of which were selected for this review. Different strategies are currently being used for the management of urethral strictures, such as clean intermittent ...
Further studies are needed in this population because of the heterogeneity of the outcomes and the lack of a standardized definition and classification of this population....