Oui, des études suggèrent un lien entre TGF-bêta et certains types de cancer.
CancerTGF-bêta
#4
Les troubles neurologiques peuvent-ils être liés ?
Oui, des troubles neurologiques peuvent être associés à des déséquilibres du TGF-bêta.
Troubles neurologiquesDéséquilibres
#5
Comment gérer les complications ?
La gestion des complications nécessite une approche multidisciplinaire et un suivi régulier.
Gestion des complicationsSuivi régulier
Facteurs de risque
5
#1
Quels sont les principaux facteurs de risque ?
Les facteurs incluent des antécédents familiaux, des maladies auto-immunes et l'exposition à des toxines.
Antécédents familiauxMaladies auto-immunes
#2
Le vieillissement est-il un facteur de risque ?
Oui, le vieillissement peut augmenter le risque de dysfonction des protéines de liaison au TGF-bêta.
VieillissementDysfonction
#3
L'obésité influence-t-elle le risque ?
Oui, l'obésité est associée à une inflammation chronique, augmentant le risque de troubles.
ObésitéInflammation chronique
#4
Le stress a-t-il un impact ?
Oui, le stress chronique peut exacerber les troubles liés au TGF-bêta.
StressTroubles
#5
Les infections peuvent-elles être un facteur ?
Oui, certaines infections peuvent déclencher des réponses inflammatoires affectant le TGF-bêta.
InfectionsRéponses inflammatoires
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Protéines de liaison au TGF-bêta latent : Questions médicales les plus fréquentes",
"headline": "Protéines de liaison au TGF-bêta latent : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Protéines de liaison au TGF-bêta latent : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-07-18",
"dateModified": "2025-04-14",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Protéines de liaison au TGF-bêta latent"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Protéines de la matrice extracellulaire",
"url": "https://questionsmedicales.fr/mesh/D016326",
"about": {
"@type": "MedicalCondition",
"name": "Protéines de la matrice extracellulaire",
"code": {
"@type": "MedicalCode",
"code": "D016326",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "D12.776.860.300"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Protéines de liaison au TGF-bêta latent",
"alternateName": "Latent TGF-beta Binding Proteins",
"code": {
"@type": "MedicalCode",
"code": "D053779",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Nalani Sachan",
"url": "https://questionsmedicales.fr/author/Nalani%20Sachan",
"affiliation": {
"@type": "Organization",
"name": "Department of Cell Biology, NYU Grossman School of Medicine, New York, New York, USA."
}
},
{
"@type": "Person",
"name": "Hui Liu",
"url": "https://questionsmedicales.fr/author/Hui%20Liu",
"affiliation": {
"@type": "Organization",
"name": "Department of Experimental Surgery, Tangdu Hospital, The Fourth Military Medical University, Xi'an, 710038, Shanxi, China."
}
},
{
"@type": "Person",
"name": "Daniel Rifkin",
"url": "https://questionsmedicales.fr/author/Daniel%20Rifkin",
"affiliation": {
"@type": "Organization",
"name": "Department of Cell Biology, NYU Grossman School of Medicine, New York, New York, USA."
}
},
{
"@type": "Person",
"name": "Karan Singh",
"url": "https://questionsmedicales.fr/author/Karan%20Singh",
"affiliation": {
"@type": "Organization",
"name": "Department of Cell Biology, NYU Grossman School of Medicine, New York, New York, USA."
}
},
{
"@type": "Person",
"name": "Hong-Lian Wang",
"url": "https://questionsmedicales.fr/author/Hong-Lian%20Wang",
"affiliation": {
"@type": "Organization",
"name": "Research Center for Integrative Medicine, The Affiliated Traditional Medicine Hospital of Southwest Medical University, Luzhou 646000, China."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "[Physical activity and exercise therapy in oncology].",
"datePublished": "2023-01-03",
"url": "https://questionsmedicales.fr/article/36594967",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s00108-022-01450-5"
}
},
{
"@type": "ScholarlyArticle",
"name": "Manual therapy and exercise for lateral elbow pain.",
"datePublished": "2024-05-28",
"url": "https://questionsmedicales.fr/article/38802121",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1002/14651858.CD013042.pub2"
}
},
{
"@type": "ScholarlyArticle",
"name": "[New approaches in exercise therapy for Parkinson's disease].",
"datePublished": "2022-11-11",
"url": "https://questionsmedicales.fr/article/36367560",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1007/s00391-022-02123-6"
}
},
{
"@type": "ScholarlyArticle",
"name": "Exercise as adjunctive therapy for systemic lupus erythematosus.",
"datePublished": "2023-04-19",
"url": "https://questionsmedicales.fr/article/37073886",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1002/14651858.CD014816.pub2"
}
},
{
"@type": "ScholarlyArticle",
"name": "Adjunctive therapies in addition to land-based exercise therapy for osteoarthritis of the hip or knee.",
"datePublished": "2022-10-17",
"url": "https://questionsmedicales.fr/article/36250418",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1002/14651858.CD011915.pub2"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Acides aminés, peptides et protéines",
"item": "https://questionsmedicales.fr/mesh/D000602"
},
{
"@type": "ListItem",
"position": 3,
"name": "Protéines",
"item": "https://questionsmedicales.fr/mesh/D011506"
},
{
"@type": "ListItem",
"position": 4,
"name": "Scléroprotéines",
"item": "https://questionsmedicales.fr/mesh/D012596"
},
{
"@type": "ListItem",
"position": 5,
"name": "Protéines de la matrice extracellulaire",
"item": "https://questionsmedicales.fr/mesh/D016326"
},
{
"@type": "ListItem",
"position": 6,
"name": "Protéines de liaison au TGF-bêta latent",
"item": "https://questionsmedicales.fr/mesh/D053779"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Protéines de liaison au TGF-bêta latent - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Protéines de liaison au TGF-bêta latent",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-06",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Protéines de liaison au TGF-bêta latent",
"description": "Comment diagnostiquer une anomalie des protéines de liaison au TGF-bêta ?\nQuels tests sont utilisés pour évaluer le TGF-bêta ?\nLes biopsies sont-elles nécessaires pour le diagnostic ?\nQuels symptômes peuvent indiquer un problème avec le TGF-bêta ?\nY a-t-il des marqueurs spécifiques pour ces protéines ?",
"url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Exercise+Therapy#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Protéines de liaison au TGF-bêta latent",
"description": "Quels symptômes sont associés à une dysfonction du TGF-bêta ?\nLa douleur est-elle un symptôme courant ?\nPeut-on observer des anomalies cutanées ?\nLes troubles respiratoires sont-ils liés au TGF-bêta ?\nY a-t-il des signes d'inflammation systémique ?",
"url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Exercise+Therapy#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Protéines de liaison au TGF-bêta latent",
"description": "Comment prévenir les troubles liés au TGF-bêta ?\nY a-t-il des mesures spécifiques à prendre ?\nLes vaccinations sont-elles importantes ?\nL'éducation des patients est-elle cruciale ?\nLe suivi médical régulier est-il recommandé ?",
"url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Exercise+Therapy#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Protéines de liaison au TGF-bêta latent",
"description": "Quels traitements sont disponibles pour les troubles liés au TGF-bêta ?\nLa thérapie génique est-elle une option ?\nLes corticostéroïdes sont-ils utilisés ?\nY a-t-il des traitements expérimentaux ?\nLes changements de mode de vie peuvent-ils aider ?",
"url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Exercise+Therapy#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Protéines de liaison au TGF-bêta latent",
"description": "Quelles complications peuvent survenir ?\nLes complications cardiovasculaires sont-elles possibles ?\nY a-t-il un risque accru de cancer ?\nLes troubles neurologiques peuvent-ils être liés ?\nComment gérer les complications ?",
"url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Exercise+Therapy#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Protéines de liaison au TGF-bêta latent",
"description": "Quels sont les principaux facteurs de risque ?\nLe vieillissement est-il un facteur de risque ?\nL'obésité influence-t-elle le risque ?\nLe stress a-t-il un impact ?\nLes infections peuvent-elles être un facteur ?",
"url": "https://questionsmedicales.fr/mesh/D053779?mesh_terms=Exercise+Therapy#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment diagnostiquer une anomalie des protéines de liaison au TGF-bêta ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le diagnostic repose sur des tests sanguins et des analyses génétiques pour détecter des mutations."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer le TGF-bêta ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des dosages immunologiques et des tests ELISA sont couramment utilisés pour mesurer le TGF-bêta."
}
},
{
"@type": "Question",
"name": "Les biopsies sont-elles nécessaires pour le diagnostic ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des biopsies peuvent être effectuées pour évaluer les tissus affectés et la présence de TGF-bêta."
}
},
{
"@type": "Question",
"name": "Quels symptômes peuvent indiquer un problème avec le TGF-bêta ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme l'inflammation chronique ou des troubles de cicatrisation peuvent indiquer un problème."
}
},
{
"@type": "Question",
"name": "Y a-t-il des marqueurs spécifiques pour ces protéines ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des marqueurs comme le TGF-bêta actif peuvent être utilisés pour évaluer leur fonction."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont associés à une dysfonction du TGF-bêta ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent des troubles immunitaires, des fibroses et des anomalies de cicatrisation."
}
},
{
"@type": "Question",
"name": "La douleur est-elle un symptôme courant ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des douleurs peuvent survenir en raison d'inflammation ou de fibrose tissulaire."
}
},
{
"@type": "Question",
"name": "Peut-on observer des anomalies cutanées ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des anomalies cutanées comme des cicatrices hypertrophiques peuvent se produire."
}
},
{
"@type": "Question",
"name": "Les troubles respiratoires sont-ils liés au TGF-bêta ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles respiratoires peuvent survenir en raison de fibrose pulmonaire associée."
}
},
{
"@type": "Question",
"name": "Y a-t-il des signes d'inflammation systémique ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des signes comme la fièvre et la fatigue peuvent indiquer une inflammation systémique."
}
},
{
"@type": "Question",
"name": "Comment prévenir les troubles liés au TGF-bêta ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention passe par un mode de vie sain et la gestion des maladies inflammatoires."
}
},
{
"@type": "Question",
"name": "Y a-t-il des mesures spécifiques à prendre ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Éviter le tabac et l'alcool peut réduire le risque de complications liées au TGF-bêta."
}
},
{
"@type": "Question",
"name": "Les vaccinations sont-elles importantes ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les vaccinations peuvent aider à prévenir les infections qui exacerbent les troubles."
}
},
{
"@type": "Question",
"name": "L'éducation des patients est-elle cruciale ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, informer les patients sur les symptômes et les facteurs de risque est essentiel."
}
},
{
"@type": "Question",
"name": "Le suivi médical régulier est-il recommandé ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un suivi médical régulier permet de détecter précocement les anomalies."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour les troubles liés au TGF-bêta ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des médicaments anti-inflammatoires et des thérapies ciblées."
}
},
{
"@type": "Question",
"name": "La thérapie génique est-elle une option ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la thérapie génique est explorée pour corriger des anomalies génétiques liées au TGF-bêta."
}
},
{
"@type": "Question",
"name": "Les corticostéroïdes sont-ils utilisés ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les corticostéroïdes peuvent être prescrits pour réduire l'inflammation associée."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements expérimentaux ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des traitements expérimentaux, comme les inhibiteurs de TGF-bêta, sont en cours d'évaluation."
}
},
{
"@type": "Question",
"name": "Les changements de mode de vie peuvent-ils aider ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des changements comme une alimentation saine et l'exercice peuvent améliorer les symptômes."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications incluent des fibroses, des troubles respiratoires et des maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "Les complications cardiovasculaires sont-elles possibles ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des complications cardiovasculaires peuvent survenir en raison d'une inflammation chronique."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque accru de cancer ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des études suggèrent un lien entre TGF-bêta et certains types de cancer."
}
},
{
"@type": "Question",
"name": "Les troubles neurologiques peuvent-ils être liés ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles neurologiques peuvent être associés à des déséquilibres du TGF-bêta."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion des complications nécessite une approche multidisciplinaire et un suivi régulier."
}
},
{
"@type": "Question",
"name": "Quels sont les principaux facteurs de risque ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des antécédents familiaux, des maladies auto-immunes et l'exposition à des toxines."
}
},
{
"@type": "Question",
"name": "Le vieillissement est-il un facteur de risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le vieillissement peut augmenter le risque de dysfonction des protéines de liaison au TGF-bêta."
}
},
{
"@type": "Question",
"name": "L'obésité influence-t-elle le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'obésité est associée à une inflammation chronique, augmentant le risque de troubles."
}
},
{
"@type": "Question",
"name": "Le stress a-t-il un impact ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut exacerber les troubles liés au TGF-bêta."
}
},
{
"@type": "Question",
"name": "Les infections peuvent-elles être un facteur ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines infections peuvent déclencher des réponses inflammatoires affectant le TGF-bêta."
}
}
]
}
]
}
Department of Medicine and Therapeutics, Li Ka Shing Institute of Health Sciences, The Chinese University of Hong Kong, Hong Kong 999077, China.
Guangdong Academy of Sciences, Guangdong Provincial People's Hospital Joint Research Laboratory on Immunological and Genetic Kidney Diseases, The Chinese University of Hong Kong, Hong Kong 999077, China.
Publications dans "Protéines de liaison au TGF-bêta latent" :
TGF-β and Cancer Group, Oncobell Program, Bellvitge Biomedical Research Institute, (IDIBELL) and University of Barcelona, L'Hospitalet de Llobregat, 08007 Barcelona, Spain.
Oncology Program, CIBEREHD, National Biomedical Research Institute on Liver and Gastrointestinal Diseases, Instituto de Salud Carlos III, 08907 Madrid, Spain.
Publications dans "Protéines de liaison au TGF-bêta latent" :
Istinye University Faculty of Medicine, Department of Internal Medicine and Rheumatology, WASOG Sarcoidosis Clinic, Turkey. Electronic address: senolkobak@yahoo.com.
Publications dans "Protéines de liaison au TGF-bêta latent" :
Optimized and individualized treatment options in oncology significantly improve the prognosis of patients. Accordingly, the management of side effects and the avoidance of long-term consequences is b...
Manual therapy and prescribed exercises are often provided together or separately in contemporary clinical practice to treat people with lateral elbow pain....
To assess the benefits and harms of manual therapy, prescribed exercises or both for adults with lateral elbow pain....
We searched the databases CENTRAL, MEDLINE and Embase, and trial registries until 31 January 2024, unrestricted by language or date of publication....
We included randomised or quasi-randomised trials. Participants were adults with lateral elbow pain. Interventions were manual therapy, prescribed exercises or both. Primary comparators were placebo o...
Two review authors independently selected studies for inclusion, extracted trial characteristics and numerical data, and assessed study risk of bias and certainty of evidence using GRADE. The main com...
Twenty-three trials (1612 participants) met our inclusion criteria (mean age ranged from 38 to 52 years, 47% female, 70% dominant arm affected). One trial (23 participants) compared manual therapy to ...
Low-certainty evidence from a single trial in people with lateral elbow pain indicates that, compared with placebo, manual therapy may provide a clinically worthwhile benefit in terms of pain and disa...
Exercise therapy is an important component in the treatment of motor symptoms in people with Parkinson's disease (PD). In this context, goal-based task-specific training has shown to be particularly e...
In this article two novel exercise interventions for targeted improvement of motor function in PD are presented: 1) task-specific training with perturbations and 2) combined task-specific and cardiova...
Summary and discussion of the current evidence for both therapeutic approaches....
First randomized controlled trials show that perturbation training is an effective task-specific training to improve gait and balance function and potentially reduce falls. Experimental findings on co...
The presented exercise approaches show promising results in first randomized controlled studies and have the potential to improve treatment outcomes in PD. Further high-quality clinical studies are ne...
Systemic lupus erythematosus (SLE) is a rare, chronic autoimmune inflammatory disease with a prevalence varying from 4.3 to 150 people in 100,000, or approximately five million people worldwide. Syste...
To evaluate the benefits and harms of structured exercise as adjunctive therapy for adults with SLE compared with usual pharmacological care, usual pharmacological care plus placebo and usual pharmaco...
We used standard, extensive Cochrane search methods. The latest search date was 30 March 2022....
We included randomised controlled trials (RCTs) of exercise as an adjunct to usual pharmacological treatment in SLE compared with placebo, usual pharmacological care alone and another non-pharmacologi...
We used standard Cochrane methods. Our major outcomes were 1. fatigue, 2. functional capacity, 3. disease activity, 4. quality of life, 5. pain, 6. serious adverse events, and 7. withdrawals due to an...
We included 13 studies (540 participants) in this review. Studies compared exercise as an adjunct to usual pharmacological care (antimalarials, immunosuppressants, and oral glucocorticoids) with usual...
Due to low- to very low-certainty evidence, we are not confident on the benefits of exercise on fatigue, functional capacity, disease activity, and pain, compared with placebo, usual care, or advice a...
Land-based exercise therapy is recommended in clinical guidelines for hip or knee osteoarthritis. Adjunctive non-pharmacological therapies are commonly used alongside exercise in hip or knee osteoarth...
To evaluate the benefits and harms of adjunctive therapies used in addition to land-based exercise therapy compared with placebo adjunctive therapy added to land-based exercise therapy, or land-based ...
We searched CENTRAL, MEDLINE, PsycINFO, EMBASE, CINAHL, Physiotherapy Evidence Database (PEDro) and clinical trials registries up to 10 June 2021....
We included randomised controlled trials (RCTs) or quasi-RCTs of people with hip or knee osteoarthritis comparing adjunctive therapies alongside land-based exercise therapy (experimental group) versus...
Two review authors independently assessed study eligibility, extracted data, and assessed risk of bias and certainty of evidence for major outcomes using GRADE....
We included 62 trials (60 RCTs and 2 quasi-RCTs) totalling 6508 participants. One trial included people with hip osteoarthritis, one hip or knee osteoarthritis and 59 included people with knee osteoar...
Moderate- to low-certainty evidence showed no difference in pain, physical function or QOL between adjunctive therapies and placebo adjunctive therapies, or in pain, physical function, QOL or joint st...
The positive effects of oncological exercise therapy are sufficiently proven according to scientific studies. International evidence-based guidelines confirm this importance and recommend physical exe...
In people with knee osteoarthritis, how much more effective is stratified exercise therapy that distinguishes three subgroups (high muscle strength subgroup, low muscle strength subgroup, obesity subg...
Pragmatic cluster randomised controlled trial in a primary care setting....
A total of 335 people with knee osteoarthritis: 153 in an experimental arm and 182 in a control arm....
Physiotherapy practices were randomised into an experimental arm providing stratified exercise therapy (supplemented by a dietary intervention from a dietician for the obesity subgroup) or a control a...
Primary outcomes were knee pain severity (numerical rating scale for pain, 0 to 10) and physical function (Knee Injury and Osteoarthritis Outcome Score subscale activities of daily living, 0 to 100). ...
Negligible differences were found between the experimental and control groups in knee pain (mean adjusted difference 0.2, 95% CI -0.4 to 0.7) and physical function (-0.8, 95% CI -4.3 to 2.6) at 3 mont...
This pragmatic trial demonstrated no added value regarding clinical outcomes of the model of stratified exercise therapy compared with usual exercise therapy. This could be attributed to the experimen...
Netherlands National Trial Register NL7463....
Soaring prevalence of hip and knee osteoarthritis (OA) inflicts high costs on the healthcare system. A further rise in the OA incidence is expected, generating increased demand of care potentially cha...
A two-armed non-inferiority randomised controlled trial will be conducted. In total, 156 patients with hip and/or knee OA will be recruited from physiotherapy clinics in primary care in Norway. Follow...
Patients will sign an informed consent form before participating in the trial. Approval has been granted by the Regional Ethics Committee (201105) and Data Protection Officer at Diakonhjemmet Hospital...
NCT04767854....
Standardized exercise therapy programs in pulmonary rehabilitation have been shown to improve physical performance and lung function parameters in post-acute COVID-19 patients. However, it has not bee...
Radiation therapy (RT) is given to about half of all people with cancer. RT alone is used to treat various cancers at different stages. Although it is a local treatment, systemic symptoms may occur. C...
To evaluate the benefits and harms of exercise plus standard care compared with standard care alone in adults with cancer receiving RT alone....
We searched CENTRAL, MEDLINE (Ovid), Embase (Ovid), CINAHL, conference proceedings and trial registries up to 26 October 2022....
We included randomised controlled trials (RCTs) that enrolled people who were receiving RT without adjuvant systemic treatment for any type or stage of cancer. We considered any type of exercise inter...
We used standard Cochrane methodology and the GRADE approach for assessing the certainty of the evidence. Our primary outcome was fatigue and the secondary outcomes were QoL, physical performance, psy...
Database searching identified 5875 records, of which 430 were duplicates. We excluded 5324 records and the remaining 121 references were assessed for eligibility. We included three two-arm RCTs with 1...
There is little evidence on the effects of exercise interventions in people with cancer who are receiving RT alone. While all included studies reported benefits for the exercise intervention groups in...
