Titre : Phosphatidylinositol-4-phosphate 3-kinase

Phosphatidylinositol-4-phosphate 3-kinase : Questions médicales fréquentes

Termes MeSH sélectionnés :

C-Peptide
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liés à PI3K ?\nY a-t-il des signes cutanés associés à PI3K ?\nLes douleurs articulaires peuvent-elles être liées à PI3K ?", "url": "https://questionsmedicales.fr/mesh/D058538?mesh_terms=C-Peptide&page=3#section-symptômes" }, { "@type": "MedicalWebPage", "name": "Prévention", "headline": "Prévention sur Phosphatidylinositol-4-phosphate 3-kinase", "description": "Peut-on prévenir les troubles liés à PI3K ?\nY a-t-il des tests de dépistage pour PI3K ?\nLes habitudes alimentaires influencent-elles PI3K ?\nL'exercice physique aide-t-il à réguler PI3K ?\nLes facteurs environnementaux affectent-ils PI3K ?", "url": "https://questionsmedicales.fr/mesh/D058538?mesh_terms=C-Peptide&page=3#section-prévention" }, { "@type": "MedicalWebPage", "name": "Traitements", "headline": "Traitements sur Phosphatidylinositol-4-phosphate 3-kinase", "description": "Quels traitements ciblent PI3K ?\nLes thérapies géniques peuvent-elles aider ?\nY a-t-il des effets secondaires des inhibiteurs de PI3K ?\nComment la nutrition influence-t-elle PI3K ?\nLes traitements sont-ils personnalisés pour PI3K ?", "url": "https://questionsmedicales.fr/mesh/D058538?mesh_terms=C-Peptide&page=3#section-traitements" }, { "@type": "MedicalWebPage", "name": "Complications", "headline": "Complications sur Phosphatidylinositol-4-phosphate 3-kinase", "description": "Quelles complications peuvent survenir avec PI3K ?\nLes maladies cardiovasculaires sont-elles liées à PI3K ?\nComment PI3K influence-t-il le cancer ?\nY a-t-il des risques de résistance aux traitements ?\nLes troubles métaboliques sont-ils réversibles ?", "url": "https://questionsmedicales.fr/mesh/D058538?mesh_terms=C-Peptide&page=3#section-complications" }, { "@type": "MedicalWebPage", "name": "Facteurs de risque", "headline": "Facteurs de risque sur Phosphatidylinositol-4-phosphate 3-kinase", "description": "Quels sont les facteurs de risque pour les troubles de PI3K ?\nL'âge influence-t-il le risque lié à PI3K ?\nLe stress a-t-il un impact sur PI3K ?\nLes antécédents familiaux jouent-ils un rôle ?\nL'alimentation influence-t-elle le risque de troubles de PI3K ?", "url": "https://questionsmedicales.fr/mesh/D058538?mesh_terms=C-Peptide&page=3#section-facteurs de risque" } ] }, { "@type": "FAQPage", "mainEntity": [ { "@type": "Question", "name": "Comment diagnostiquer une dysfonction de PI3K ?", "position": 1, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques et des analyses biochimiques peuvent être utilisés pour diagnostiquer les anomalies de PI3K." } }, { "@type": "Question", "name": "Quels tests sont utilisés pour évaluer PI3K ?", "position": 2, "acceptedAnswer": { "@type": "Answer", "text": "Les tests d'activité enzymatique et les dosages de métabolites spécifiques sont courants." } }, { "@type": "Question", "name": "Les biopsies sont-elles nécessaires pour le diagnostic ?", "position": 3, "acceptedAnswer": { "@type": "Answer", "text": "Des biopsies peuvent être nécessaires pour évaluer l'expression de PI3K dans les tissus." } }, { "@type": "Question", "name": "Quels symptômes peuvent indiquer un problème avec PI3K ?", "position": 4, "acceptedAnswer": { "@type": "Answer", "text": "Des symptômes variés comme des troubles métaboliques ou des anomalies de croissance peuvent survenir." } }, { "@type": "Question", "name": "Y a-t-il des marqueurs spécifiques pour PI3K ?", "position": 5, "acceptedAnswer": { "@type": "Answer", "text": "Des marqueurs moléculaires comme PIK3CA peuvent indiquer une activation anormale de PI3K." } }, { "@type": "Question", "name": "Quels sont les symptômes d'une activation anormale de PI3K ?", "position": 6, "acceptedAnswer": { "@type": "Answer", "text": "Les symptômes incluent des troubles métaboliques, des anomalies de croissance et des cancers." } }, { "@type": "Question", "name": "Comment PI3K affecte-t-il le métabolisme ?", "position": 7, "acceptedAnswer": { "@type": "Answer", "text": "PI3K régule le métabolisme en influençant la signalisation de l'insuline et la lipogenèse." } }, { "@type": "Question", "name": "Les troubles neurologiques sont-ils liés à PI3K ?", "position": 8, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des dysfonctionnements de PI3K peuvent être associés à des troubles neurologiques." } }, { "@type": "Question", "name": "Y a-t-il des signes cutanés associés à PI3K ?", "position": 9, "acceptedAnswer": { "@type": "Answer", "text": "Des anomalies cutanées peuvent apparaître, notamment dans des syndromes génétiques liés à PI3K." } }, { "@type": "Question", "name": "Les douleurs articulaires peuvent-elles être liées à PI3K ?", "position": 10, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des troubles inflammatoires peuvent être exacerbés par des anomalies de PI3K." } }, { "@type": "Question", "name": "Peut-on prévenir les troubles liés à PI3K ?", "position": 11, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation saine et un mode de vie actif peuvent réduire les risques associés à PI3K." } }, { "@type": "Question", "name": "Y a-t-il des tests de dépistage pour PI3K ?", "position": 12, "acceptedAnswer": { "@type": "Answer", "text": "Des tests génétiques peuvent être recommandés pour les personnes à risque de troubles liés à PI3K." } }, { "@type": "Question", "name": "Les habitudes alimentaires influencent-elles PI3K ?", "position": 13, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une alimentation riche en acides gras oméga-3 peut moduler l'activité de PI3K." } }, { "@type": "Question", "name": "L'exercice physique aide-t-il à réguler PI3K ?", "position": 14, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exercice régulier peut améliorer la signalisation de PI3K et la santé métabolique." } }, { "@type": "Question", "name": "Les facteurs environnementaux affectent-ils PI3K ?", "position": 15, "acceptedAnswer": { "@type": "Answer", "text": "Oui, l'exposition à certains toxiques peut influencer l'activité de PI3K et le risque de maladies." } }, { "@type": "Question", "name": "Quels traitements ciblent PI3K ?", "position": 16, "acceptedAnswer": { "@type": "Answer", "text": "Des inhibiteurs de PI3K sont utilisés dans le traitement de certains cancers et maladies métaboliques." } }, { "@type": "Question", "name": "Les thérapies géniques peuvent-elles aider ?", "position": 17, "acceptedAnswer": { "@type": "Answer", "text": "Oui, la thérapie génique peut corriger des mutations dans les gènes codant pour PI3K." } }, { "@type": "Question", "name": "Y a-t-il des effets secondaires des inhibiteurs de PI3K ?", "position": 18, "acceptedAnswer": { "@type": "Answer", "text": "Les effets secondaires peuvent inclure des troubles gastro-intestinaux et des infections." } }, { "@type": "Question", "name": "Comment la nutrition influence-t-elle PI3K ?", "position": 19, "acceptedAnswer": { "@type": "Answer", "text": "Une alimentation équilibrée peut moduler l'activité de PI3K et améliorer la santé métabolique." } }, { "@type": "Question", "name": "Les traitements sont-ils personnalisés pour PI3K ?", "position": 20, "acceptedAnswer": { "@type": "Answer", "text": "Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques de PI3K." } }, { "@type": "Question", "name": "Quelles complications peuvent survenir avec PI3K ?", "position": 21, "acceptedAnswer": { "@type": "Answer", "text": "Des complications incluent des cancers, des troubles métaboliques et des maladies cardiovasculaires." } }, { "@type": "Question", "name": "Les maladies cardiovasculaires sont-elles liées à PI3K ?", "position": 22, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des anomalies de PI3K peuvent contribuer à des maladies cardiovasculaires par des mécanismes inflammatoires." } }, { "@type": "Question", "name": "Comment PI3K influence-t-il le cancer ?", "position": 23, "acceptedAnswer": { "@type": "Answer", "text": "PI3K est souvent activé dans divers cancers, favorisant la croissance tumorale et la survie cellulaire." } }, { "@type": "Question", "name": "Y a-t-il des risques de résistance aux traitements ?", "position": 24, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des mutations dans PI3K peuvent entraîner une résistance aux inhibiteurs de PI3K." } }, { "@type": "Question", "name": "Les troubles métaboliques sont-ils réversibles ?", "position": 25, "acceptedAnswer": { "@type": "Answer", "text": "Certains troubles métaboliques liés à PI3K peuvent être gérés par des changements de mode de vie." } }, { "@type": "Question", "name": "Quels sont les facteurs de risque pour les troubles de PI3K ?", "position": 26, "acceptedAnswer": { "@type": "Answer", "text": "Les facteurs incluent des prédispositions génétiques, l'obésité et un mode de vie sédentaire." } }, { "@type": "Question", "name": "L'âge influence-t-il le risque lié à PI3K ?", "position": 27, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le risque de troubles liés à PI3K augmente avec l'âge en raison de l'accumulation de mutations." } }, { "@type": "Question", "name": "Le stress a-t-il un impact sur PI3K ?", "position": 28, "acceptedAnswer": { "@type": "Answer", "text": "Oui, le stress chronique peut affecter la signalisation de PI3K et contribuer à des maladies." } }, { "@type": "Question", "name": "Les antécédents familiaux jouent-ils un rôle ?", "position": 29, "acceptedAnswer": { "@type": "Answer", "text": "Oui, des antécédents familiaux de cancers ou de troubles métaboliques augmentent le risque." } }, { "@type": "Question", "name": "L'alimentation influence-t-elle le risque de troubles de PI3K ?", "position": 30, "acceptedAnswer": { "@type": "Answer", "text": "Oui, une alimentation riche en sucres et graisses saturées peut augmenter le risque." } } ] } ] }

Sources (10000 au total)

Relationship of Glucose, C-peptide, Leptin, and BDNF in Maternal and Umbilical Vein Blood in Type-1 Diabetes.

The study aimed to determine the relationship between glucose, C-peptide, brain-derived neurotrophic factor (BDNF), and leptin between mother and fetus and neonatal weight.... In the prospective observational cohort study, we included 66 women with type-1 diabetes mellitus (T1DM). According to the z-score for neonatal weight, patients were divided into healthy-weight neonat... A strong correlation was confirmed between maternal and umbilical vein glucose concentration and maternal glucose and C-peptide in umbilical vein blood. A negative correlation was found between the co... Maternal glucose concentrations affect the fetus's glucose, C-peptide, and BDNF concentrations. Leptin levels increase in maternal blood due to increased body mass index, and in the neonate, fat body ...

Association of C-peptide level with peripheral neuropathy in type 2 diabetes: An observational cross-sectional preliminary study.

Peripheral neuropathy is the most common microvascular complication of diabetes mellitus. In subjects with type 1 diabetes (T1D) relationship of C-peptide levels and neuropathy has been observed in se... One hundred patients of T2D were included in this study. Clinical and laboratory parameter was assessed for all participants. The C-peptide level was measured by fluorometric enzyme immunoassay method... Total 100 patients completed the study. Mean age of subjects was 60.03 years and male: female ratio was 1.17. Peripheral neuropathy was detected in 47% of subjects evaluated. Subjects were further div... Serum C-peptide concentrations are associated with peripheral neuropathy in T2DM patients, independent of the degree of glycemic control....

Abnormal late postprandial glucagon response in type 1 diabetes is a function of differences in stimulated C-peptide concentrations.

The functional changes in alpha cells in patients with type 1 diabetes (T1D) with different residual beta cell functions remain poorly elucidated. The study aimed to investigate the relationship betwe... The study enrolled 43 adult patients with T1D and 24 healthy control subjects. Patients with T1D who underwent BMTT were divided into two groups based on peak C-peptide levels: C peptide low (CPL; C-p... Compared to healthy individuals, fasting plasma glucagon was lower and postprandial plasma glucagon level was increased in patients with T1D. Glucagon levels after BMTT between the CPL and CPH group s... Stimulated C-peptide levels affect the paradoxical increase in postprandial glucagon secretion in patients with T1D, especially late glucagon response. The exaggerated postprandial glucagon secretion ...

The average 30-minute post-prandial C-peptide predicted diabetic retinopathy progress: a retro-prospective study.

The conclusion between Connecting peptide (C-peptide) and diabetic chronic complication was controversial. The purpose of this study is to explore the possible association between average C-peptide wi... This is a retro-prospective study. 622 patients with type 2 diabetes were included. DR was evaluated using non-mydriatic fundus photography and DR progression was defined as any deterioration of eithe... DR was present in 162 (26.0%) patients at baseline, and 26.4% of patients were found progression of DR at follow-up. Patients with progression of DR had lower average levels of 30-minute postprandial ... Our results suggest that the Average 30-minute post-prandial C-peptide and increment were negatively correlated with DR progression, which further demonstrates the importance to preserve β-cell residu... Not applicable....

Urinary c-peptide creatinine ratio (UCPCR) as a predictor of coronary artery disease in type 1 diabetes mellitus.

Elevated C-peptide has been suggested as a risk factor for coronary artery disease (CAD). Elevated urinary C-peptide to creatinine ratio (UCPCR) as an alternative measurement is shown to be related to... 279 patients previously diagnosed with T1DM included and categorized into two groups of CAD (n = 84) and without-CAD (n = 195). Furthermore, each group was divided into obese (body mass index (BMI) ≥ ... Median level of UCPCR was higher in CAD group compared to non-CAD group (0.07 vs. 0.04, respectively). Also, the well-acknowledged risk factors including being active smoker, hypertension, duration of... UCPCR is associated with clinical CAD, independent of CAD classic risk factors, glycaemic control, insulin resistance and BMI in type 1 DM patients....

Application of urine C-peptide creatinine ratio in type 2 diabetic patients with different levels of renal function.

This study aims to investigate the effect of single urine C peptide/creatinine (UCPCR) in assessing the islet β Cell function of type 2 diabetes mellitus (T2DM) patients with different renal function.... A total of 85 T2DM patients were recruited in this study, all the patients were assigned to one group with estimated glomerular filtration rate (eGFR)≤60 ml·min... When compared with group eGFR ≤60 ml·min... UCPCR can be used to evaluate islets β Cell function in T2DM patients with different renal function status....

Association of serum C-peptide with all-cause and cardiovascular disease mortality in ultrasound-defined nonalcoholic fatty liver disease.

To determine the prognostic value of C-peptide in long-term nonalcoholic fatty liver disease (NAFLD) mortality.... A total of 4670 participants with NAFLD were enrolled in this study. Multivariable Cox regression models evaluated the links between C-peptide levels and all-cause and cardiovascular disease (CVD) mor... After a mean follow‑up period of 20 years, 1714 deaths from all causes were recorded. In an adjusted Cox regression analysis, using the low C-peptide group as the reference (quartile 1), higher C-pept... In the US NAFLD population defined by ultrasound, a U-shaped association was detected between baseline serum C-peptide level and all-cause mortality....