questionsmedicales.fr
Acides aminés, peptides et protéines
Protéines
Protéines et peptides de signalisation intracellulaire
Phosphatidylinositol 3-kinases
Phosphatidylinositol-4-phosphate 3-kinase
Phosphatidylinositol-4-phosphate 3-kinase : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Kinases
Diagnostic médical
Tests de laboratoire
Phosphatidylinositols
Biopsie
Phosphatidylinositols
Symptômes
Phosphatidylinositols
Marqueurs biologiques
Phosphatidylinositols
Symptômes
5
Symptômes
Phosphatidylinositols
Troubles neurologiques
Phosphatidylinositols
Anomalies cutanées
Phosphatidylinositols
Douleurs articulaires
Phosphatidylinositols
Prévention
5
Prévention
Mode de vie sain
Dépistage
Tests génétiques
Habitudes alimentaires
Phosphatidylinositols
Exercice physique
Métabolisme
Facteurs environnementaux
Phosphatidylinositols
Traitements
5
Inhibiteurs
Traitement du cancer
Thérapie génique
Phosphatidylinositols
Effets secondaires
Inhibiteurs
Médecine personnalisée
Phosphatidylinositols
Complications
5
Complications
Phosphatidylinositols
Maladies cardiovasculaires
Phosphatidylinositols
Cancer
Phosphatidylinositols
Résistance aux traitements
Phosphatidylinositols
Troubles métaboliques
Phosphatidylinositols
Facteurs de risque
5
Facteurs de risque
Obésité
Âge
Phosphatidylinositols
Stress
Phosphatidylinositols
Antécédents familiaux
Phosphatidylinositols
Alimentation
Phosphatidylinositols
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"name": "Comment diagnostiquer une dysfonction de PI3K ?",
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"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer PI3K ?",
"position": 2,
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"@type": "Question",
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"@type": "Question",
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"@type": "Question",
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"@type": "Question",
"name": "Quels sont les symptômes d'une activation anormale de PI3K ?",
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"@type": "Question",
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"@type": "Question",
"name": "Les troubles neurologiques sont-ils liés à PI3K ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des dysfonctionnements de PI3K peuvent être associés à des troubles neurologiques."
}
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{
"@type": "Question",
"name": "Y a-t-il des signes cutanés associés à PI3K ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies cutanées peuvent apparaître, notamment dans des syndromes génétiques liés à PI3K."
}
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{
"@type": "Question",
"name": "Les douleurs articulaires peuvent-elles être liées à PI3K ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des troubles inflammatoires peuvent être exacerbés par des anomalies de PI3K."
}
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"@type": "Question",
"name": "Peut-on prévenir les troubles liés à PI3K ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation saine et un mode de vie actif peuvent réduire les risques associés à PI3K."
}
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{
"@type": "Question",
"name": "Y a-t-il des tests de dépistage pour PI3K ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques peuvent être recommandés pour les personnes à risque de troubles liés à PI3K."
}
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"@type": "Question",
"name": "Les habitudes alimentaires influencent-elles PI3K ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en acides gras oméga-3 peut moduler l'activité de PI3K."
}
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{
"@type": "Question",
"name": "L'exercice physique aide-t-il à réguler PI3K ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer la signalisation de PI3K et la santé métabolique."
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"@type": "Question",
"name": "Les facteurs environnementaux affectent-ils PI3K ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certains toxiques peut influencer l'activité de PI3K et le risque de maladies."
}
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{
"@type": "Question",
"name": "Quels traitements ciblent PI3K ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs de PI3K sont utilisés dans le traitement de certains cancers et maladies métaboliques."
}
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{
"@type": "Question",
"name": "Les thérapies géniques peuvent-elles aider ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la thérapie génique peut corriger des mutations dans les gènes codant pour PI3K."
}
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{
"@type": "Question",
"name": "Y a-t-il des effets secondaires des inhibiteurs de PI3K ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les effets secondaires peuvent inclure des troubles gastro-intestinaux et des infections."
}
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{
"@type": "Question",
"name": "Comment la nutrition influence-t-elle PI3K ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut moduler l'activité de PI3K et améliorer la santé métabolique."
}
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"@type": "Question",
"name": "Les traitements sont-ils personnalisés pour PI3K ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction des mutations spécifiques de PI3K."
}
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{
"@type": "Question",
"name": "Quelles complications peuvent survenir avec PI3K ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des cancers, des troubles métaboliques et des maladies cardiovasculaires."
}
},
{
"@type": "Question",
"name": "Les maladies cardiovasculaires sont-elles liées à PI3K ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des anomalies de PI3K peuvent contribuer à des maladies cardiovasculaires par des mécanismes inflammatoires."
}
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{
"@type": "Question",
"name": "Comment PI3K influence-t-il le cancer ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "PI3K est souvent activé dans divers cancers, favorisant la croissance tumorale et la survie cellulaire."
}
},
{
"@type": "Question",
"name": "Y a-t-il des risques de résistance aux traitements ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des mutations dans PI3K peuvent entraîner une résistance aux inhibiteurs de PI3K."
}
},
{
"@type": "Question",
"name": "Les troubles métaboliques sont-ils réversibles ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains troubles métaboliques liés à PI3K peuvent être gérés par des changements de mode de vie."
}
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{
"@type": "Question",
"name": "Quels sont les facteurs de risque pour les troubles de PI3K ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des prédispositions génétiques, l'obésité et un mode de vie sédentaire."
}
},
{
"@type": "Question",
"name": "L'âge influence-t-il le risque lié à PI3K ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le risque de troubles liés à PI3K augmente avec l'âge en raison de l'accumulation de mutations."
}
},
{
"@type": "Question",
"name": "Le stress a-t-il un impact sur PI3K ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut affecter la signalisation de PI3K et contribuer à des maladies."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux jouent-ils un rôle ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de cancers ou de troubles métaboliques augmentent le risque."
}
},
{
"@type": "Question",
"name": "L'alimentation influence-t-elle le risque de troubles de PI3K ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation riche en sucres et graisses saturées peut augmenter le risque."
}
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Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 27/02/2025
Contenu vérifié selon les dernières recommandations médicales
4 publications dans cette catégorie
Affiliations :
Cellular Organization and Signaling, National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore, 560065, India. Electronic address: praghu@ncbs.res.in.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India; Manipal Academy of Higher Education, Manipal, Karnataka 576104, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, 611-0011 Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, 611-0011 Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Institute for Chemical Research, Kyoto University, Gokasho, Uji, Kyoto, 611-0011 Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Section on Molecular Signal Transduction, Eunice Kennedy Shriver National Institute of Child Health and Human Development, National Institutes of Health, Bethesda, MD, USA ballat@mail.nih.gov.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Department of Biochemistry and Microbiology, University of Victoria, Victoria, British Columbia, Canada; Department of Biochemistry and Molecular Biology, The University of British Columbia, Vancouver, British Columbia, Canada.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Leibniz-Forschungsinstitut für Molekulare Pharmakologie (FMP), Berlin, Germany. haucke@fmp-berlin.de.
Departments of Biology, Chemistry, and Pharmacy, Freie Universität Berlin, Berlin, Germany. haucke@fmp-berlin.de.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Medical Research Institute, Tokyo Women's Medical University, 8-1 Kawada-cho, Shinjuku-ku, Tokyo 162-8666, Japan.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
3 publications dans cette catégorie
Affiliations :
Department of Molecular and Cell Biology and Biochemistry, Basic Veterinary Science, Faculty of Veterinary Medicine, Kagoshima University, Korimoto 1-21-24, Kagoshima 890-0065, Japan. Electronic address: afujita@vet.kagoshima-u.ac.jp.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
Sandra and Edward Meyer Cancer Center, Weill Cornell Medicine, New York, New York, USA.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
National Centre for Biological Sciences, TIFR-GKVK Campus, Bellary Road, Bangalore 560065, India.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
2 publications dans cette catégorie
Affiliations :
Department of Biochemistry, University of Toronto, ON, M5S 1A8, Toronto, Canada. greg.fairn@unityhealth.to.
Keenan Research Centre for Biomedical Sciences, St. Michael's Hospital, 209 Victoria Street, Toronto, ON, M5B 1T8, Canada. greg.fairn@unityhealth.to.
Department of Surgery, University of Toronto, Toronto, ON, M5T 1P5, Canada. greg.fairn@unityhealth.to.
Publications dans "Phosphatidylinositol-4-phosphate 3-kinase" :
For two decades, the international scholarly publishing community has been embroiled in a divisive debate about the best model for funding the dissemination of scientific research. Some may assume tha...
Publishing in health professions education (HPE) journals is an integral component of academic discourse and career progression. Research in this field is shifting to an open access (OA) publishing mo...
To identify the characteristics and publishing models of HPE journals and explore potential associations between publication costs and journal metrics....
This cross-sectional study was conducted between September 20, 2023, and February 14, 2024, using the World Bank purchasing power parity (PPP) index to analyze relative costs of article processing cha...
Two-year impact factor, H-index, cite score, Scientific Journal Ranking, and APC....
Among the 51 journals included, 27 (53%) adopted OA-only and 24 (47%) adopted hybrid publishing models. The median (IQR) APC for all journals was $2820.00 ($928.00-$3300.00). Associations were observe...
Results of this cross-sectional study suggest that adoption by HPE journals of an OA publishing model was high but access to APC waivers or discounts was limited. These factors create barriers to equi...
Since the 1990s, journals have become increasingly online and open access. In fact, about 50% of articles published in 2021 were open access. The use of preprints (i.e., non-peer-reviewed articles) ha...
Research impact and influence are commonly measured quantitatively by citation count received by research articles. Many institutes also use citation count as one of the factors in faculty performance...
Cross-sectional study design....
Articles published in top nursing journals in 2016 were identified in PUBMED and the citation metrics for individual articles until 2021 were extracted from Scopus. The primary outcome was the citatio...
A total of 2210 articles were included in this study, of which 223 (10.1%) were review articles. The median (IQR) number of Scopus citations, tweets, countries, and percentage of authors with Research...
This study provides empirical support for some strategies researchers may employ to amplify the citation count of their research articles. The methodology of our study can be extended to compare resea...
The citation refers to the research work cited by peers and is one of the indicators for research impact. Higher citations implied the research work is read and used by others, therefore, understandin...
Open access publishing has exhibited rapid growth in recent years. However, there is uncertainty surrounding the quality of open access journals and their ability to reach target audiences. This study...
The directory of open access journals was used to search for open access surgical journals. PubMed indexing status, impact factor, article processing charge (APC), initial year of open access publishi...
Ninety-two open access surgical journals were identified. Most (n = 49, 53.3%) were indexed in PubMed. Journals established >10 y were more likely to be indexed in PubMed compared to journals establis...
Open access surgical journals are largely indexed on PubMed, have transparent review processes, employ variable APCs (including no publication fees), and proceed efficiently from submission to publica...
Open access (OA) publishing provides free online access to research articles without subscription fees. In Brazil, absence of financial support from academic institutions and limited government polici...
Open-access (OA) publishing is increasingly prevalent in dermatology, and many journals now offer hybrid options, including conventional (subscription-based access [SA]) publishing or OA (with an auth...
Using the Clarivate Journal Citation Report, we compiled a list of English-language dermatology hybrid OA journals containing more than 5% OA articles. We sampled any OA review or original research ar...
Twenty-seven hybrid dermatology journals were found, and 538 articles were sampled (269 OA, 269 SA). For both original research and review articles, OA articles had significantly higher mean citation ...
We noted a higher citation count for OA articles than SA articles in dermatology hybrid journals. However, dermatology researchers should take into account confounding factors when deciding whether to...
Our research activities would be better served if they were communicated in a manner that is openly accessible to the public and all researchers. The research we share is often limited to representati...
During the last decades, the Open Access paradigm has become an important approach for publishing new scientific knowledge. From 2015 to 2020, the Trans-O-MIM research project was undertaken with the ...
To present an overview of the outcomes of the Trans-O-MIM research project as a whole and to share our major lessons learned....
As an approach for transforming journals, a Tandem Model has been proposed and implemented for...
Based on the Tandem Model, the journal...
With Trans-O-MIM, an international research project was performed. An existing journal has been transformed. In addition, with the support of the International Medical Informatics Association, as well...
Neuropsychopharmacology (NPP) offers the option to publish articles in different tiers of an open access (OA) publishing system: Green, Bronze, or Hybrid. Green articles follow a standard access (SA) ...