Peut-on modifier les facteurs de risque liés aux gènes modificateurs ?
Certaines modifications du mode de vie peuvent réduire le risque, mais pas tous les facteurs sont modifiables.
Modification du mode de vieRisque génétique
{
"@context": "https://schema.org",
"@graph": [
{
"@type": "MedicalWebPage",
"name": "Gènes modificateurs : Questions médicales les plus fréquentes",
"headline": "Gènes modificateurs : Comprendre les symptômes, diagnostics et traitements",
"description": "Guide complet et accessible sur les Gènes modificateurs : explications, diagnostics, traitements et prévention. Information médicale validée destinée aux patients.",
"datePublished": "2024-01-30",
"dateModified": "2025-04-24",
"inLanguage": "fr",
"medicalAudience": [
{
"@type": "MedicalAudience",
"name": "Grand public",
"audienceType": "Patient",
"healthCondition": {
"@type": "MedicalCondition",
"name": "Gènes modificateurs"
},
"suggestedMinAge": 18,
"suggestedGender": "unisex"
},
{
"@type": "MedicalAudience",
"name": "Médecins",
"audienceType": "Physician",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "France"
}
},
{
"@type": "MedicalAudience",
"name": "Chercheurs",
"audienceType": "Researcher",
"geographicArea": {
"@type": "AdministrativeArea",
"name": "International"
}
}
],
"reviewedBy": {
"@type": "Person",
"name": "Dr Olivier Menir",
"jobTitle": "Expert en Médecine",
"description": "Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale",
"url": "/static/pages/docteur-olivier-menir.html",
"alumniOf": {
"@type": "EducationalOrganization",
"name": "Université Paris Descartes"
}
},
"isPartOf": {
"@type": "MedicalWebPage",
"name": "Gènes",
"url": "https://questionsmedicales.fr/mesh/D005796",
"about": {
"@type": "MedicalCondition",
"name": "Gènes",
"code": {
"@type": "MedicalCode",
"code": "D005796",
"codingSystem": "MeSH"
},
"identifier": {
"@type": "PropertyValue",
"propertyID": "MeSH Tree",
"value": "G05.360.340.024.340"
}
}
},
"about": {
"@type": "MedicalCondition",
"name": "Gènes modificateurs",
"alternateName": "Genes, Modifier",
"code": {
"@type": "MedicalCode",
"code": "D060045",
"codingSystem": "MeSH"
}
},
"author": [
{
"@type": "Person",
"name": "Harriet Corvol",
"url": "https://questionsmedicales.fr/author/Harriet%20Corvol",
"affiliation": {
"@type": "Organization",
"name": "Sorbonne Université, Inserm U938, Centre de Recherche Saint-Antoine (CRSA), 75012 Paris, France."
}
},
{
"@type": "Person",
"name": "Yuanjian Chen",
"url": "https://questionsmedicales.fr/author/Yuanjian%20Chen",
"affiliation": {
"@type": "Organization",
"name": "Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States of America."
}
},
{
"@type": "Person",
"name": "Fuyi Xu",
"url": "https://questionsmedicales.fr/author/Fuyi%20Xu",
"affiliation": {
"@type": "Organization",
"name": "Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States of America."
}
},
{
"@type": "Person",
"name": "Robert W Williams",
"url": "https://questionsmedicales.fr/author/Robert%20W%20Williams",
"affiliation": {
"@type": "Organization",
"name": "Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States of America."
}
},
{
"@type": "Person",
"name": "Syamal K Bhattacharya",
"url": "https://questionsmedicales.fr/author/Syamal%20K%20Bhattacharya",
"affiliation": {
"@type": "Organization",
"name": "Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States of America."
}
}
],
"citation": [
{
"@type": "ScholarlyArticle",
"name": "Differences in a Musician's Advantage for Speech-in-Speech Perception Based on Age and Task.",
"datePublished": "2023-02-02",
"url": "https://questionsmedicales.fr/article/36729698",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1044/2022_JSLHR-22-00259"
}
},
{
"@type": "ScholarlyArticle",
"name": "Lilliput: speech perception in speech-weighted noise and in quiet in young children.",
"datePublished": "2022-06-22",
"url": "https://questionsmedicales.fr/article/35732012",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1080/14992027.2022.2086491"
}
},
{
"@type": "ScholarlyArticle",
"name": "Towards a somatosensory theory of speech perception.",
"datePublished": "2022-11-23",
"url": "https://questionsmedicales.fr/article/36416451",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1152/jn.00381.2022"
}
},
{
"@type": "ScholarlyArticle",
"name": "Online Ternary Classification of Covert Speech by Leveraging the Passive Perception of Speech.",
"datePublished": "2023-07-31",
"url": "https://questionsmedicales.fr/article/37522623",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1142/S012906572350048X"
}
},
{
"@type": "ScholarlyArticle",
"name": "Sensorimotor foundations of speech perception in infancy.",
"datePublished": "2023-06-09",
"url": "https://questionsmedicales.fr/article/37302917",
"identifier": {
"@type": "PropertyValue",
"propertyID": "DOI",
"value": "10.1016/j.tics.2023.05.007"
}
}
],
"breadcrumb": {
"@type": "BreadcrumbList",
"itemListElement": [
{
"@type": "ListItem",
"position": 1,
"name": "questionsmedicales.fr",
"item": "https://questionsmedicales.fr"
},
{
"@type": "ListItem",
"position": 2,
"name": "Phénomènes génétiques",
"item": "https://questionsmedicales.fr/mesh/D055614"
},
{
"@type": "ListItem",
"position": 3,
"name": "Structures génétiques",
"item": "https://questionsmedicales.fr/mesh/D040342"
},
{
"@type": "ListItem",
"position": 4,
"name": "Génome",
"item": "https://questionsmedicales.fr/mesh/D016678"
},
{
"@type": "ListItem",
"position": 5,
"name": "Composants de génome",
"item": "https://questionsmedicales.fr/mesh/D040481"
},
{
"@type": "ListItem",
"position": 6,
"name": "Gènes",
"item": "https://questionsmedicales.fr/mesh/D005796"
},
{
"@type": "ListItem",
"position": 7,
"name": "Gènes modificateurs",
"item": "https://questionsmedicales.fr/mesh/D060045"
}
]
}
},
{
"@type": "MedicalWebPage",
"name": "Article complet : Gènes modificateurs - Questions et réponses",
"headline": "Questions et réponses médicales fréquentes sur Gènes modificateurs",
"description": "Une compilation de questions et réponses structurées, validées par des experts médicaux.",
"datePublished": "2025-05-08",
"inLanguage": "fr",
"hasPart": [
{
"@type": "MedicalWebPage",
"name": "Diagnostic",
"headline": "Diagnostic sur Gènes modificateurs",
"description": "Comment identifier les gènes modificateurs ?\nQuels tests sont utilisés pour les gènes modificateurs ?\nLes gènes modificateurs sont-ils testés en routine ?\nPeut-on détecter les gènes modificateurs par imagerie ?\nQuel rôle jouent les gènes modificateurs dans le diagnostic ?",
"url": "https://questionsmedicales.fr/mesh/D060045?mesh_terms=Speech+Perception#section-diagnostic"
},
{
"@type": "MedicalWebPage",
"name": "Symptômes",
"headline": "Symptômes sur Gènes modificateurs",
"description": "Les gènes modificateurs affectent-ils les symptômes ?\nQuels symptômes sont liés aux gènes modificateurs ?\nLes gènes modificateurs causent-ils des symptômes ?\nPeut-on prédire les symptômes avec des gènes modificateurs ?\nLes gènes modificateurs sont-ils liés à des symptômes spécifiques ?",
"url": "https://questionsmedicales.fr/mesh/D060045?mesh_terms=Speech+Perception#section-symptômes"
},
{
"@type": "MedicalWebPage",
"name": "Prévention",
"headline": "Prévention sur Gènes modificateurs",
"description": "Peut-on prévenir les effets des gènes modificateurs ?\nY a-t-il des mesures préventives spécifiques ?\nLes gènes modificateurs nécessitent-ils une prévention ciblée ?\nComment la recherche aide-t-elle à la prévention ?\nLes gènes modificateurs influencent-ils le mode de vie préventif ?",
"url": "https://questionsmedicales.fr/mesh/D060045?mesh_terms=Speech+Perception#section-prévention"
},
{
"@type": "MedicalWebPage",
"name": "Traitements",
"headline": "Traitements sur Gènes modificateurs",
"description": "Les traitements ciblent-ils les gènes modificateurs ?\nComment les gènes modificateurs influencent-ils le traitement ?\nY a-t-il des traitements spécifiques pour les gènes modificateurs ?\nLes gènes modificateurs affectent-ils l'efficacité des médicaments ?\nPeut-on modifier les gènes modificateurs par traitement ?",
"url": "https://questionsmedicales.fr/mesh/D060045?mesh_terms=Speech+Perception#section-traitements"
},
{
"@type": "MedicalWebPage",
"name": "Complications",
"headline": "Complications sur Gènes modificateurs",
"description": "Quels types de complications sont liés aux gènes modificateurs ?\nLes gènes modificateurs augmentent-ils les complications ?\nComment gérer les complications liées aux gènes modificateurs ?\nLes complications sont-elles prévisibles avec des gènes modificateurs ?\nLes gènes modificateurs sont-ils impliqués dans des complications spécifiques ?",
"url": "https://questionsmedicales.fr/mesh/D060045?mesh_terms=Speech+Perception#section-complications"
},
{
"@type": "MedicalWebPage",
"name": "Facteurs de risque",
"headline": "Facteurs de risque sur Gènes modificateurs",
"description": "Quels sont les facteurs de risque liés aux gènes modificateurs ?\nLes gènes modificateurs augmentent-ils le risque de maladies ?\nComment évaluer les facteurs de risque génétiques ?\nLes facteurs environnementaux influencent-ils les gènes modificateurs ?\nPeut-on modifier les facteurs de risque liés aux gènes modificateurs ?",
"url": "https://questionsmedicales.fr/mesh/D060045?mesh_terms=Speech+Perception#section-facteurs de risque"
}
]
},
{
"@type": "FAQPage",
"mainEntity": [
{
"@type": "Question",
"name": "Comment identifier les gènes modificateurs ?",
"position": 1,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'analyse génétique et les études d'association sont utilisées pour identifier ces gènes."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour les gènes modificateurs ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les tests de séquençage et les SNP (polymorphismes nucléotidiques) sont couramment utilisés."
}
},
{
"@type": "Question",
"name": "Les gènes modificateurs sont-ils testés en routine ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, leur test n'est pas systématique et dépend des maladies spécifiques."
}
},
{
"@type": "Question",
"name": "Peut-on détecter les gènes modificateurs par imagerie ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, l'imagerie ne permet pas de détecter les gènes modificateurs, seuls les tests génétiques le peuvent."
}
},
{
"@type": "Question",
"name": "Quel rôle jouent les gènes modificateurs dans le diagnostic ?",
"position": 5,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils aident à comprendre la variabilité des maladies et à affiner le diagnostic."
}
},
{
"@type": "Question",
"name": "Les gènes modificateurs affectent-ils les symptômes ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent influencer la gravité et la présentation des symptômes d'une maladie."
}
},
{
"@type": "Question",
"name": "Quels symptômes sont liés aux gènes modificateurs ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes varient selon la maladie, mais incluent souvent des manifestations cliniques variées."
}
},
{
"@type": "Question",
"name": "Les gènes modificateurs causent-ils des symptômes ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, ils modifient l'expression des symptômes causés par d'autres gènes."
}
},
{
"@type": "Question",
"name": "Peut-on prédire les symptômes avec des gènes modificateurs ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Partiellement, car ils peuvent influencer la sévérité mais pas toujours la présence des symptômes."
}
},
{
"@type": "Question",
"name": "Les gènes modificateurs sont-ils liés à des symptômes spécifiques ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains gènes modificateurs sont associés à des symptômes spécifiques dans certaines maladies."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir les effets des gènes modificateurs ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "La prévention est complexe, mais une surveillance et un dépistage précoce peuvent aider."
}
},
{
"@type": "Question",
"name": "Y a-t-il des mesures préventives spécifiques ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des conseils génétiques et des tests peuvent être proposés aux familles à risque."
}
},
{
"@type": "Question",
"name": "Les gènes modificateurs nécessitent-ils une prévention ciblée ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la prévention peut être ciblée en fonction des gènes modificateurs identifiés."
}
},
{
"@type": "Question",
"name": "Comment la recherche aide-t-elle à la prévention ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "La recherche sur les gènes modificateurs aide à identifier des stratégies préventives efficaces."
}
},
{
"@type": "Question",
"name": "Les gènes modificateurs influencent-ils le mode de vie préventif ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent guider les recommandations de mode de vie pour réduire les risques."
}
},
{
"@type": "Question",
"name": "Les traitements ciblent-ils les gènes modificateurs ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certains traitements peuvent être adaptés en fonction des gènes modificateurs identifiés."
}
},
{
"@type": "Question",
"name": "Comment les gènes modificateurs influencent-ils le traitement ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Ils peuvent déterminer la réponse au traitement et la nécessité d'une approche personnalisée."
}
},
{
"@type": "Question",
"name": "Y a-t-il des traitements spécifiques pour les gènes modificateurs ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, il n'existe pas de traitements spécifiques, mais des approches personnalisées peuvent être envisagées."
}
},
{
"@type": "Question",
"name": "Les gènes modificateurs affectent-ils l'efficacité des médicaments ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent influencer l'efficacité et les effets secondaires des médicaments."
}
},
{
"@type": "Question",
"name": "Peut-on modifier les gènes modificateurs par traitement ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des recherches sont en cours sur la thérapie génique, mais ce n'est pas encore courant."
}
},
{
"@type": "Question",
"name": "Quels types de complications sont liés aux gènes modificateurs ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les complications varient selon la maladie, incluant des formes plus graves ou résistantes."
}
},
{
"@type": "Question",
"name": "Les gènes modificateurs augmentent-ils les complications ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent augmenter le risque de complications dans certaines conditions génétiques."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications liées aux gènes modificateurs ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une gestion proactive et personnalisée est essentielle pour minimiser les complications."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles prévisibles avec des gènes modificateurs ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Partiellement, car certains gènes modificateurs peuvent indiquer un risque accru de complications."
}
},
{
"@type": "Question",
"name": "Les gènes modificateurs sont-ils impliqués dans des complications spécifiques ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains gènes modificateurs sont associés à des complications spécifiques dans certaines maladies."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque liés aux gènes modificateurs ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs de risque incluent des antécédents familiaux et des variations génétiques spécifiques."
}
},
{
"@type": "Question",
"name": "Les gènes modificateurs augmentent-ils le risque de maladies ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent augmenter le risque de développer certaines maladies génétiques."
}
},
{
"@type": "Question",
"name": "Comment évaluer les facteurs de risque génétiques ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "L'évaluation se fait par des tests génétiques et des conseils génétiques appropriés."
}
},
{
"@type": "Question",
"name": "Les facteurs environnementaux influencent-ils les gènes modificateurs ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'environnement peut interagir avec les gènes modificateurs et influencer le risque."
}
},
{
"@type": "Question",
"name": "Peut-on modifier les facteurs de risque liés aux gènes modificateurs ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines modifications du mode de vie peuvent réduire le risque, mais pas tous les facteurs sont modifiables."
}
}
]
}
]
}
Department of Genetics, Genomics and Informatics, University of Tennessee Health Science Center, Memphis, TN, United States of America. Electronic address: llu@uthsc.edu.
Division of Cardiovascular Diseases, Department of Medicine, University of Tennessee Health Science Center, Memphis, TN, United States of America. Electronic address: yasun@uthsc.edu.
This study investigates the debate that musicians have an advantage in speech-in-noise perception from years of targeted auditory training. We also consider the effect of age on any such advantage, co...
Participants (ranging in age from 18 to 66 years) included 29 musicians and 26 nonmusicians. They completed two tasks varying in attentional demands: (a) a selective attention task where listeners ide...
Results show that increasing differences in...
Overall, we find support for a hybrid...
https://doi.org/10.23641/asha.21956777....
The aim of this study was to develop an open-set word recognition task in speech-weighted noise and in quiet for young children and examine age effects for open versus closed response formats....
Dutch monosyllabic words were presented in quiet and in stationary speech-weighted noise to 4- and 5-year-old children as well as to young adults in an open-set response format. Additionally, performa...
More than 200 children and 50 adults with normal hearing participated in the various validation phases....
Average fitted speech reception thresholds (50%) yielded an age effect between 4-year and 5-year olds (and adults), both in speech-weighted noise and in quiet. The closed-set format yielded lower (bet...
The same materials reveal performance differences between 4 and 5 years of age (and adults), both in quiet and speech-weighted noise using an open-set response format. This relatively small yet signif...
Speech perception is known to be a multimodal process, relying not only on auditory input but also on the visual system and possibly on the motor system as well. To date there has been little work on ...
Brain-computer interfaces (BCIs) provide communicative alternatives to those without functional speech. Covert speech (CS)-based BCIs enable communication simply by thinking of words and thus have int...
The perceptual system for speech is highly organized from early infancy. This organization bootstraps young human learners' ability to acquire their native speech and language from speech input. Here,...
Beyond hallmark production deficits characterizing childhood apraxia of speech (CAS), largely attributed to disruption(s) in speech motor planning, children with CAS often present with co-occurring sp...
This tutorial summarizes the current literature on speech perception and how it relates to speech production, language, and reading abilities for children with CAS. We include case illustrations that ...
Although speech perception difficulties do not seem to be a core deficit of CAS, they are strongly linked to language difficulties, which are highly prevalent among children with CAS. Speech perceptio...
Children with CAS who have co-occurring language difficulties likely also demonstrate speech perception deficits, which puts them at heightened risk for reading difficulties and struggles with academi...
Investigate if speech perception skills can differentiate school children with Specific Reading Disorders (SRD) with and without Persistent Speech Sound Disorders (PSSD)....
80 children, regularly enrolled in the 2nd (N=1), 3rd (N=28), 4th (N=29), 5th (N=15) and 6th (N=7) grades participated in the study. Control Group (CG) (N=48): no complaints, no speech alteration; and...
Control and RGI showed higher correct answer scores than RGII. There was no difference between the correct answer distributions of the Control and RGI, and RGI and RGII in the test of DNPLS and the nu...
The ability to discriminate non-words enabled the differentiated between school-aged children with SRD associated with PSSD and typical children, thus characterizing this group for presenting a number...
Sensory gating is the cortical phenomenon that involves selective inhibition of responses to task-irrelevant stimuli. Perceiving speech in noise, a situation commonly encountered by humans, requires t...
An observational research following a correlational design was conducted on 10 neurotypical individuals. Auditory sensory gating was assessed using a conditioning-testing paradigm for tone and speech ...
Differences were observed in the gating index of the P2 peaks of speech and tone pairs. A significant relationship between SPiN and the auditory sensory gating of the P2 peak of the speech-evoked cort...
The results of this preliminary investigation indicate an association between the sensory gating mechanism and neurotypical individuals' ability to perceive speech in noise....
To analyze the performance of auditory speech perception (PF) after cochlear implant (CI) replacement surgery and associations with age, times of use of the first CI, deprivation, recovery and use of ...
The retrospective study analyzed the medical records of 68 participants reimplanted from 1990 to 2016, and evaluated with PF performance tests, considering as a reference, the greater auditory capacit...
Most were children with hearing loss due to idiopathic causes and meningitis. Abrupt stoppage of operation was the most common cause for device replacement. Most cases recovered and maintained or cont...
Periodic programming and replacement of the device when indicated are fundamental for the maintenance of auditory functions. Being young and having longer use of implants represent advantages for the ...
Individuals with autism spectrum disorder (ASD) exhibit atypical speech-in-noise (SiN) perception, but the scope of these impairments has not been clearly defined. We conducted a systematic review of ...
