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Acides aminés, peptides et protéines
Protéines
Nucléoprotéines
Protéines chromosomiques nonhistones
Protéines de maintenance des minichromosomes
Protéines de maintenance des minichromosomes : Questions médicales fréquentes
Termes MeSH sélectionnés :
Diagnostic
5
Protéines de maintenance des minichromosomes
Tests génétiques
Protéines de maintenance des minichromosomes
Immunobuvardage
Protéines de maintenance des minichromosomes
Biologie moléculaire
Protéines de maintenance des minichromosomes
Marqueurs tumoraux
Protéines de maintenance des minichromosomes
Cancers
Symptômes
5
Protéines de maintenance des minichromosomes
Dysfonctionnement cellulaire
Protéines de maintenance des minichromosomes
Maladies génétiques
Protéines de maintenance des minichromosomes
Santé cellulaire
Protéines de maintenance des minichromosomes
Troubles neurologiques
Protéines de maintenance des minichromosomes
Croissance cellulaire
Prévention
5
Protéines de maintenance des minichromosomes
Prévention des maladies
Protéines de maintenance des minichromosomes
Dépistage génétique
Protéines de maintenance des minichromosomes
Nutrition
Protéines de maintenance des minichromosomes
Stress
Protéines de maintenance des minichromosomes
Exercice physique
Traitements
5
Protéines de maintenance des minichromosomes
Inhibiteurs
Protéines de maintenance des minichromosomes
Thérapie génique
Protéines de maintenance des minichromosomes
Médicaments anticancéreux
Protéines de maintenance des minichromosomes
Chimiothérapie
Protéines de maintenance des minichromosomes
Médecine personnalisée
Complications
5
Protéines de maintenance des minichromosomes
Complications
Protéines de maintenance des minichromosomes
Hérédité
Protéines de maintenance des minichromosomes
Vieillissement
Protéines de maintenance des minichromosomes
Maladies auto-immunes
Protéines de maintenance des minichromosomes
Troubles neurologiques
Facteurs de risque
5
Protéines de maintenance des minichromosomes
Facteurs de risque
Protéines de maintenance des minichromosomes
Toxines
Protéines de maintenance des minichromosomes
Tabagisme
Protéines de maintenance des minichromosomes
Vieillissement
Protéines de maintenance des minichromosomes
Antécédents familiaux
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"@type": "Question",
"name": "Comment diagnostiquer une anomalie des protéines MCM ?",
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"text": "Des tests génétiques et des analyses de protéines peuvent identifier des anomalies."
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"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer les MCM ?",
"position": 2,
"acceptedAnswer": {
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"text": "L'immunobuvardage et la PCR sont couramment utilisés pour évaluer les MCM."
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"@type": "Question",
"name": "Les niveaux de MCM peuvent-ils être mesurés ?",
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"position": 4,
"acceptedAnswer": {
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"text": "Les marqueurs de prolifération cellulaire, comme Ki-67, sont souvent associés aux MCM."
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"@type": "Question",
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"@type": "Question",
"name": "Quels symptômes indiquent une dysfonction des MCM ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des anomalies dans la réplication de l'ADN peuvent entraîner des symptômes variés."
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"@type": "Question",
"name": "Les symptômes sont-ils spécifiques aux MCM ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Non, les symptômes peuvent varier selon le type de maladie associée aux MCM."
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{
"@type": "Question",
"name": "Comment les MCM affectent-elles la santé cellulaire ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une mauvaise fonction des MCM peut entraîner des erreurs dans la réplication de l'ADN."
}
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"@type": "Question",
"name": "Les MCM sont-elles liées à des symptômes neurologiques ?",
"position": 9,
"acceptedAnswer": {
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"text": "Certaines études suggèrent un lien entre les MCM et des troubles neurologiques."
}
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{
"@type": "Question",
"name": "Peut-on observer des symptômes précoces de dysfonction MCM ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des signes précoces peuvent inclure des anomalies de croissance cellulaire."
}
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{
"@type": "Question",
"name": "Peut-on prévenir les anomalies des MCM ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une bonne hygiène de vie et un suivi médical régulier peuvent aider à prévenir."
}
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{
"@type": "Question",
"name": "Y a-t-il des tests de dépistage pour les MCM ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests génétiques peuvent être proposés pour les personnes à risque élevé."
}
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{
"@type": "Question",
"name": "L'alimentation influence-t-elle les MCM ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Une alimentation équilibrée peut soutenir la santé cellulaire et la fonction des MCM."
}
},
{
"@type": "Question",
"name": "Le stress affecte-t-il les MCM ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le stress chronique peut perturber la fonction cellulaire, y compris celle des MCM."
}
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{
"@type": "Question",
"name": "Les exercices physiques aident-ils les MCM ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer la santé cellulaire et la fonction des MCM."
}
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{
"@type": "Question",
"name": "Quels traitements ciblent les MCM ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des inhibiteurs spécifiques de MCM sont en cours de développement pour le cancer."
}
},
{
"@type": "Question",
"name": "Les thérapies géniques peuvent-elles aider ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la thérapie génique pourrait corriger les anomalies des MCM dans certains cas."
}
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"@type": "Question",
"name": "Y a-t-il des médicaments pour les MCM ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des médicaments ciblant la voie de réplication de l'ADN sont en développement."
}
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"@type": "Question",
"name": "Comment la chimiothérapie affecte-t-elle les MCM ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "La chimiothérapie peut perturber la fonction des MCM, affectant la réplication cellulaire."
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"@type": "Question",
"name": "Les traitements sont-ils personnalisés pour les MCM ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements peuvent être adaptés en fonction des profils de MCM des patients."
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"@type": "Question",
"name": "Quelles complications peuvent survenir avec des anomalies MCM ?",
"position": 21,
"acceptedAnswer": {
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"text": "Des complications incluent des cancers, des troubles de croissance et des maladies génétiques."
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"@type": "Question",
"name": "Les anomalies MCM sont-elles héréditaires ?",
"position": 22,
"acceptedAnswer": {
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"text": "Certaines anomalies peuvent être héréditaires, augmentant le risque de maladies."
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"@type": "Question",
"name": "Comment les MCM affectent-elles le vieillissement ?",
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"acceptedAnswer": {
"@type": "Answer",
"text": "Des dysfonctionnements des MCM peuvent accélérer le vieillissement cellulaire et tissulaire."
}
},
{
"@type": "Question",
"name": "Les MCM sont-elles liées à des maladies auto-immunes ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des recherches suggèrent un lien potentiel entre les MCM et certaines maladies auto-immunes."
}
},
{
"@type": "Question",
"name": "Les anomalies MCM peuvent-elles causer des troubles neurologiques ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des anomalies dans les MCM peuvent être associées à des troubles neurologiques."
}
},
{
"@type": "Question",
"name": "Quels facteurs augmentent le risque d'anomalies MCM ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des facteurs génétiques, environnementaux et liés au mode de vie peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "L'exposition à des toxines influence-t-elle les MCM ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exposition à certaines toxines peut perturber la fonction des MCM."
}
},
{
"@type": "Question",
"name": "Le tabagisme affecte-t-il les MCM ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Le tabagisme est un facteur de risque connu pour des anomalies dans la fonction des MCM."
}
},
{
"@type": "Question",
"name": "Le vieillissement est-il un facteur de risque pour les MCM ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le vieillissement peut affecter la fonction des MCM et augmenter le risque de maladies."
}
},
{
"@type": "Question",
"name": "Les antécédents familiaux influencent-ils les MCM ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des antécédents familiaux de maladies liées aux MCM peuvent augmenter le risque."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 02/04/2025
Contenu vérifié selon les dernières recommandations médicales
3 publications dans cette catégorie
Affiliations :
Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, 600# Tianhe Road, Guangzhou, 510630, China.
Publications dans "Protéines de maintenance des minichromosomes" :
3 publications dans cette catégorie
Affiliations :
Department of Hepatobiliary Surgery, The First Affiliated Hospital of Gannan Medical University, Ganzhou, 341000, China.
Publications dans "Protéines de maintenance des minichromosomes" :
3 publications dans cette catégorie
Affiliations :
Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, 600# Tianhe Road, Guangzhou, 510630, China.
Publications dans "Protéines de maintenance des minichromosomes" :
3 publications dans cette catégorie
Affiliations :
Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, 600# Tianhe Road, Guangzhou, 510630, China.
Publications dans "Protéines de maintenance des minichromosomes" :
3 publications dans cette catégorie
Affiliations :
Cell-gene Therapy Translational Medicine Research Center, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.
Publications dans "Protéines de maintenance des minichromosomes" :
3 publications dans cette catégorie
Affiliations :
Guangdong Key Laboratory of Liver Disease Research, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, 510630, China.
Publications dans "Protéines de maintenance des minichromosomes" :
3 publications dans cette catégorie
Affiliations :
Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, 600# Tianhe Road, Guangzhou, 510630, China.
Publications dans "Protéines de maintenance des minichromosomes" :
3 publications dans cette catégorie
Affiliations :
Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, 600# Tianhe Road, Guangzhou, 510630, China. zhjianw2@mail.sysu.edu.cn.
Publications dans "Protéines de maintenance des minichromosomes" :
3 publications dans cette catégorie
Affiliations :
Department of Medical Oncology of the Eastern Hospital, The First Affiliated Hospital of Sun Yat-sen University, Zhongshan Er Road, Guangzhou, 510080, China. drliheping@163.com.
Publications dans "Protéines de maintenance des minichromosomes" :
3 publications dans cette catégorie
Affiliations :
Department of Hepatic Surgery and Liver transplantation Center of the Third Affiliated Hospital, Organ Transplantation Institute, Sun Yat-sen University, Organ Transplantation Research Center of Guangdong Province, 600# Tianhe Road, Guangzhou, 510630, China. fubinsh@mail.sysu.edu.cn.
Publications dans "Protéines de maintenance des minichromosomes" :
2 publications dans cette catégorie
Affiliations :
Department of Thoracic Surgery, Renmin Hospital of Wuhan University, Wuhan, Hubei 430060, P.R. China.
Publications dans "Protéines de maintenance des minichromosomes" :
2 publications dans cette catégorie
Affiliations :
State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat-Sen University, Guangdong Provincial Key Laboratory of Ophthalmology and Visual Science, Guangzhou, China.
Publications dans "Protéines de maintenance des minichromosomes" :
2 publications dans cette catégorie
Affiliations :
Center for Reproductive Medicine, Shandong University, National Research Center for Assisted Reproductive Technology and Reproductive Genetics, and Key Laboratory of Reproductive Endocrinology (Shandong University), Ministry of Education, Jinan, Shandong, People's Republic of China.
Publications dans "Protéines de maintenance des minichromosomes" :
1 publication dans cette catégorie
Affiliations :
Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Telangana, India.
Publications dans "Protéines de maintenance des minichromosomes" :
1 publication dans cette catégorie
Affiliations :
Molecular Biology and Genetics Unit, Jawaharlal Nehru Center for Advanced Scientific Research, Bangalore, India.
Publications dans "Protéines de maintenance des minichromosomes" :
1 publication dans cette catégorie
Affiliations :
Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Telangana, India.
Publications dans "Protéines de maintenance des minichromosomes" :
1 publication dans cette catégorie
Affiliations :
Department of Biotechnology, Indian Institute of Technology Hyderabad, Kandi, Telangana, India.
Publications dans "Protéines de maintenance des minichromosomes" :
1 publication dans cette catégorie
Affiliations :
Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai, India.
Publications dans "Protéines de maintenance des minichromosomes" :
1 publication dans cette catégorie
Affiliations :
Department of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Publications dans "Protéines de maintenance des minichromosomes" :
1 publication dans cette catégorie
Affiliations :
Department of Microbiology and Immunology, University of Nevada, Reno School of Medicine, Reno, Nevada, USA.
Publications dans "Protéines de maintenance des minichromosomes" :
A subset of patients needing long-term enteral access are unable to undergo a conventional transoral "pull" percutaneous endoscopic gastrostomy (PEG). We assessed the safety and efficacy of an introdu...
In this single center, non-randomized, pilot study, patients unable to undergo a transoral Pull PEG were prospectively recruited for a DPEG during the index endoscopy. IRG procedures performed at our ...
A total of 47 patients (68.3 ± 7.13 years) underwent DPEG and 45 patients (68.6 ± 8.23 years) underwent IRG. The respective Charlson comorbidity scores were 6.37 ± 2 and 6.16 ± 1.72 (P = 0.59). Malign...
DPEG is a safe and effective alternative to IRG in patients unable to undergo a conventional transoral pull PEG and may be considered as a primary modality for enteral support....
gov Identifier: NCT04151030....
Gastrostomy tubes benefit patients but also introduce hazards and costs. Most of these costs tend to be administratively invisible, but clinically expensive. Nurses, residents, emergency physicians, s...
Gastroenterologists are frequently consulted for evaluation feeding tube placement, or for management of complications in an existing feeding tube. Though a frequent topic of consultation for GI Fello...
At present, percutaneous endoscopic gastrostomy (PEG) is the procedure of choice in establishing a permanent feeding tube in patients with chronic severe dysphagia. This is the first prospective rando...
Randomization of 106 patients, eligible for both techniques, to PEG (pull method) or RIG. The groups were comparable in terms of age, body mass index, and underlying diseases. Adverse events were repo...
The procedures were successfully completed in all patients. The median operative time was 10 min for PEG and 20 min for RIG (p < 0.001). The overall rate of adverse events was lower for PEG (22%) than...
PEG can be recommended as the primary procedure in patients in need of a feeding gastrostomy, mainly due to a lower frequency of tube complications. However, as the two techniques complement each othe...
International Standard Randomized Controlled Trial Number ISRCTN17642761. https://doi.org/10.1186/ISRCTN17642761....
For percutaneous endoscopic gastrostomy (PEG)-fed head and neck cancer (HNC) patients, risk markers of poor outcomes may identify those needing more intensive support. This retrospective study aimed t...
To demonstrate the safety and effectiveness of percutaneous transesophageal gastrostomy (PTEG) as a palliative option in patients with malignant bowel obstructions (MBOs), and provide a comprehensive ...
Thirty-eight consecutive patients who underwent a PTEG procedure attempt from 2014 to 2022 were included in this analysis. Clinical indications, method of placement, technical and clinical success, ad...
Of the 38 patients who underwent PTEG, 19 (50%) were men and 19 (50%) were women (median age, 58 years; range, 21-75 years). Three (8%) PTEG placements were performed with the patients under moderate ...
PTEG is an effective and safe option for patients with contraindications to traditional percutaneous gastrostomy tube placement in the setting of MBO. PTEG is an effective means of providing palliatio...
Gastrostomy buttons (g-buttons) are commonly placed in children to facilitate weight gain, correct nutritional deficiencies, and provide hydration and/or medication delivery. At our institution, paren...
In 2016, a pediatric surgeon and a team of graduate engineering students outlined the problem, created a list of design requirements, and began to iterate on a variety of device designs....
Over 400 design ideas were iterated upon to various degrees. The first prototype was studied in a small clinical trial, in which 80% of caregivers reported satisfaction with the design, but 90% noted ...
An intuitive g-button securement device was created to simplify daily gauze replacement, reduce tract-related complications, and lower the cost of care. A randomized controlled trial comparing the sec...
Peristomal wound infection is a common complication in patients receiving percutaneous endoscopic gastrostomy (PEG). The main reason for peristomal infection might be the oral microbes coating the gas...
A total of 50 patients were randomized to Betadine and control groups (25 patients in each group) from April 2014 to August 2021 at a tertiary medical center. All patients received the pull method for...
Changes in Neutrophil/Lymphocyte ratio (N/L ratio) and C-Reative protein (Delta CRP) at 24 h after PEG were higher in the control group than in the Betadine group (N/L ratio, 3.1 vs. 1.2, p = 0.047; C...
The betadine coating gastrostomy tube method could not reduce peristomal infection after percutaneous endoscopic gastrostomy. CRP elevation of less than 3 mg/dl may be used to exclude the potential pe...
NCT04249570 ( https://clinicaltrials.gov/ct2/show/NCT04249570 )....
This study aimed to determine the relationship between scoliosis and risk of developing complications in patients who underwent gastrostomy....
Patients who underwent percutaneous endoscopic gastrostomy (PEG) or surgical gastrostomy (SG) between 2012 and 2022 were included. Leakage, discharge, granuloma, and hyperemia were considered minor co...
A total of 104 patients with a mean age of 5.0 ± 5.3 were included; 58% of patients were treated with SG. Patients in the SG group were younger ( P < 0.001). Minor complications were significantly mor...
Gastrostomy is important for weight gain and nutritional needs of children. This study showed that the risk of complications in SGs did not correlate with the degree of scoliosis and that the risk of ...
CL is a 94-year-old male who is brought to the Emergency Department from an assisted living facility due to a new onset of weakness and altered mental status. He was in his usual state of moderately c...