Laboratory of Growth Regulators, Institute of Experimental Botany of the Czech Academy of Sciences & Palacký University, Šlechtitelů 27, Olomouc, Czech Republic.
Department of Chemistry of Natural Compounds, Faculty of Food and Biochemical Technology, University of Chemistry and Technology in Prague, Technická 5, Prague, Czech Republic.
Department of Chemical Biology and Genetics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, Olomouc, Czech Republic.
Publications dans "Inhibiteurs de l'acétaldéhyde déshydrogénase" :
Department of Protein Biochemistry and Proteomics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, Olomouc, Czech Republic.
Publications dans "Inhibiteurs de l'acétaldéhyde déshydrogénase" :
Department of Protein Biochemistry and Proteomics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, Olomouc, Czech Republic.
Publications dans "Inhibiteurs de l'acétaldéhyde déshydrogénase" :
Department of Molecular Biology, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, Olomouc, Czech Republic.
Publications dans "Inhibiteurs de l'acétaldéhyde déshydrogénase" :
Department of Chemical Biology and Genetics, Centre of the Region Haná for Biotechnological and Agricultural Research, Faculty of Science, Palacký University, Šlechtitelů 27, Olomouc, Czech Republic.
Publications dans "Inhibiteurs de l'acétaldéhyde déshydrogénase" :
Department of Otolaryngology, Head and Neck Surgery, and Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Publications dans "Inhibiteurs de l'acétaldéhyde déshydrogénase" :
Department of Otolaryngology, Head and Neck Surgery, and Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Department of Otolaryngology, Guangdong Women and Children Hospital, Guangzhou, China.
Publications dans "Inhibiteurs de l'acétaldéhyde déshydrogénase" :
Department of Otolaryngology, Head and Neck Surgery, and Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Publications dans "Inhibiteurs de l'acétaldéhyde déshydrogénase" :
Department of Otolaryngology, Head and Neck Surgery, and Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Publications dans "Inhibiteurs de l'acétaldéhyde déshydrogénase" :
Department of Otolaryngology, Head and Neck Surgery, and Guangdong Provincial Key Laboratory of Malignant Tumor Epigenetics and Gene Regulation, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, Guangzhou, China.
Publications dans "Inhibiteurs de l'acétaldéhyde déshydrogénase" :
CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China.
University of Chinese Academy of Sciences, CAS, Beijing, China.
Publications dans "Inhibiteurs de l'acétaldéhyde déshydrogénase" :
CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China.
University of Chinese Academy of Sciences, CAS, Beijing, China.
School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Publications dans "Inhibiteurs de l'acétaldéhyde déshydrogénase" :
CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China.
University of Chinese Academy of Sciences, CAS, Beijing, China.
Publications dans "Inhibiteurs de l'acétaldéhyde déshydrogénase" :
CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China.
University of Chinese Academy of Sciences, CAS, Beijing, China.
Publications dans "Inhibiteurs de l'acétaldéhyde déshydrogénase" :
CAS Key Laboratory of Nutrition, Metabolism and Food Safety, Shanghai Institute of Nutrition and Health, Shanghai Institutes for Biological Sciences (SIBS), Chinese Academy of Sciences (CAS), Shanghai, China.
University of Chinese Academy of Sciences, CAS, Beijing, China.
School of Life Science and Technology, ShanghaiTech University, Shanghai, China.
Key Laboratory of Food Safety Risk Assessment, Ministry of Health, Beijing, China.
Publications dans "Inhibiteurs de l'acétaldéhyde déshydrogénase" :
It is generally accepted that Cyclooxygenase-2 (COX-2) is activated to cause inflammation. However, COX-2 is also constitutively expressed at the postsynaptic dendrites and excitatory terminals of the...
Cyclooxygenases (COX) catalyze the committed step in the production of prostaglandins responsible for the maintenance of physiological homeostasis. While crystal structures of COX in complex with subs...
Molecular imaging probes enable the early and accurate detection of disease-specific biomarkers and facilitate personalized treatment of many chronic diseases, including cancer. Among current clinical...
Periapical granuloma (PG) and cyst (PC) are formed as a protective response consequent to pulpal infection leaching through the apical foramen and lateral canals. Various inflammatory mediators like m...
An observational and cross-sectional study was conducted on paraffin-embedded tissue sections of 50 PGs and 50 PCs submitted for morphological and immunohistochemical analysis using anti-tryptase and ...
The inflammatory score, total mast cells and COX-2 expression were similar in PGs and PCs (p = .352, .339 and .352) however, the degranulated mast cells were highly significant in PC while granulated ...
Mast cells and cyclooxygenase-2 proved to be independent inflammatory markers in periapical lesions. Further studies should be planned on mast cell and COX-2 inhibitors as treatment modalities of peri...
Novel tolfenamic acid derivatives based on the structure of I-1 were designed and synthesized to improve its poor target inhibition and solubility. Among them, W10 was identified as a potent dual-targ...
Cyclooxygenase (COX) isozymes, i.e., COX-1 and COX-2, are encoded by separate genes and are involved in the generation of the same products, prostaglandin (PG)G...
Screening of novel cyclooxygenase-2 (COX-2) inhibitors from complex natural products is not an easy task....
To establish an efficient and feasible strategy for screening COX-2 inhibitors from triterpenoid saponins (TPSs) in Clematis tangutica....
Taking TPSs in C. tangutica as example, an optimized macroporous resin (MR) method was established for the enrichment of TPSs. High-performance liquid chromatography-quadrupole time-of-flight mass spe...
TPSs in C. tangutica were well enriched with the recovery rate of (80.22 ± 2.37)%. Thirty-four kinds of TPSs of oleanane type were deduced by HPLC-QTOFMS. Five TPSs of clematangoside C, clematangoside...
The integrated strategy using MR, HPLC-QTOFMS, molecular docking, chemometrics, target preparation, and in vitro verification was feasible for rapidly screening COX-2 inhibitors from TPSs in C. tangut...
Manganese (Mn) is an essential cofactor for many enzymes and plays an important role in normal growth and development. However, excess exposure to manganese (Mn) may be an important environmental fact...
Cyclooxygenase-2 plays a role in oncogenesis and its overexpression is associated with triple-negative breast cancer. However, the mechanisms whereby cyclooxygenase-2 contribute to breast cancer are c...