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Actions chimiques et utilisations
Actions pharmacologiques
Effets physiologiques des médicaments
Agents neuromédiateurs
Agents cholinergiques
Inhibiteurs de la libération d'acétylcholine
Inhibiteurs de la libération d'acétylcholine : Questions médicales fréquentes
Termes MeSH sélectionnés :
Bronchial Provocation Tests
Diagnostic
5
Diagnostic
Acétylcholine
Neurologie
Tests électromyographiques
Acétylcholine
Analyse sanguine
Faiblesse musculaire
Fatigue
Acétylcholine
Antécédents médicaux
Acétylcholine
Évaluation clinique
Imagerie cérébrale
Pathologies neurologiques
Acétylcholine
Symptômes
5
Faiblesse musculaire
Fatigue
Coordination
Troubles de la mémoire
Concentration
Acétylcholine
Difficultés respiratoires
Acétylcholine
Système respiratoire
Âge
Symptômes
Acétylcholine
Nausées
Troubles gastro-intestinaux
Acétylcholine
Prévention
5
Prévention
Mode de vie sain
Acétylcholine
Alimentation équilibrée
Antioxydants
Acétylcholine
Exercice physique
Fonction musculaire
Acétylcholine
Stress
Symptômes
Acétylcholine
Contrôles réguliers
Surveillance
Acétylcholine
Traitements
5
Médicaments anticholinestérasiques
Thérapies physiques
Acétylcholine
Efficacité des traitements
Qualité de vie
Acétylcholine
Effets secondaires
Nausées
Acétylcholine
Rééducation physique
Renforcement musculaire
Acétylcholine
Traitements personnalisés
Acétylcholine
Médecine personnalisée
Complications
5
Complications
Troubles respiratoires
Crises musculaires
Hospitalisations
Surveillance
Acétylcholine
Risque de décès
Inhibition sévère
Acétylcholine
Complications réversibles
Traitement approprié
Acétylcholine
Gestion des complications
Approche multidisciplinaire
Acétylcholine
Facteurs de risque
5
Facteurs de risque
Maladies auto-immunes
Antécédents familiaux
Âge avancé
Facteurs de risque
Acétylcholine
Médicaments
Risque
Acétylcholine
Mode de vie sédentaire
Mauvaise alimentation
Acétylcholine
Infections virales
Risque
Acétylcholine
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"description": "Comment diagnostiquer une inhibition de l'acétylcholine ?\nQuels tests sont utilisés pour évaluer l'acétylcholine ?\nQuels symptômes indiquent une inhibition d'acétylcholine ?\nLes antécédents médicaux sont-ils importants ?\nPeut-on utiliser l'imagerie pour le diagnostic ?",
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"description": "Quels traitements sont disponibles pour l'inhibition ?\nLes traitements sont-ils efficaces ?\nY a-t-il des effets secondaires aux traitements ?\nLa rééducation est-elle recommandée ?\nLes traitements sont-ils personnalisés ?",
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"@type": "Question",
"name": "Comment diagnostiquer une inhibition de l'acétylcholine ?",
"position": 1,
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"text": "Le diagnostic repose sur des tests neurologiques et l'évaluation des symptômes cliniques."
}
},
{
"@type": "Question",
"name": "Quels tests sont utilisés pour évaluer l'acétylcholine ?",
"position": 2,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des tests électromyographiques et des analyses sanguines peuvent être utilisés."
}
},
{
"@type": "Question",
"name": "Quels symptômes indiquent une inhibition d'acétylcholine ?",
"position": 3,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des symptômes comme la faiblesse musculaire et la fatigue peuvent indiquer une inhibition."
}
},
{
"@type": "Question",
"name": "Les antécédents médicaux sont-ils importants ?",
"position": 4,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les antécédents médicaux aident à identifier des causes potentielles d'inhibition."
}
},
{
"@type": "Question",
"name": "Peut-on utiliser l'imagerie pour le diagnostic ?",
"position": 5,
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"text": "L'imagerie cérébrale peut aider à exclure d'autres pathologies neurologiques."
}
},
{
"@type": "Question",
"name": "Quels sont les symptômes courants d'une inhibition ?",
"position": 6,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les symptômes incluent faiblesse musculaire, fatigue, et troubles de la coordination."
}
},
{
"@type": "Question",
"name": "L'inhibition affecte-t-elle la cognition ?",
"position": 7,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, elle peut entraîner des troubles de la mémoire et de la concentration."
}
},
{
"@type": "Question",
"name": "Y a-t-il des symptômes respiratoires associés ?",
"position": 8,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des difficultés respiratoires peuvent survenir en cas d'inhibition sévère."
}
},
{
"@type": "Question",
"name": "Les symptômes varient-ils selon l'âge ?",
"position": 9,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les symptômes peuvent être plus prononcés chez les personnes âgées."
}
},
{
"@type": "Question",
"name": "Peut-on avoir des symptômes digestifs ?",
"position": 10,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des nausées et des troubles gastro-intestinaux peuvent se manifester."
}
},
{
"@type": "Question",
"name": "Peut-on prévenir l'inhibition d'acétylcholine ?",
"position": 11,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines mesures préventives incluent un mode de vie sain et la gestion du stress."
}
},
{
"@type": "Question",
"name": "L'alimentation joue-t-elle un rôle ?",
"position": 12,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, une alimentation équilibrée riche en antioxydants peut soutenir la santé neuronale."
}
},
{
"@type": "Question",
"name": "L'exercice physique est-il bénéfique ?",
"position": 13,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'exercice régulier peut améliorer la fonction musculaire et nerveuse."
}
},
{
"@type": "Question",
"name": "Le stress peut-il aggraver l'inhibition ?",
"position": 14,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, le stress chronique peut exacerber les symptômes d'inhibition d'acétylcholine."
}
},
{
"@type": "Question",
"name": "Des contrôles réguliers sont-ils nécessaires ?",
"position": 15,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des contrôles réguliers permettent de surveiller l'évolution et d'ajuster les traitements."
}
},
{
"@type": "Question",
"name": "Quels traitements sont disponibles pour l'inhibition ?",
"position": 16,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les traitements incluent des médicaments anticholinestérasiques et des thérapies physiques."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils efficaces ?",
"position": 17,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, ils peuvent améliorer les symptômes et la qualité de vie des patients."
}
},
{
"@type": "Question",
"name": "Y a-t-il des effets secondaires aux traitements ?",
"position": 18,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des effets secondaires comme des nausées et des crampes peuvent survenir."
}
},
{
"@type": "Question",
"name": "La rééducation est-elle recommandée ?",
"position": 19,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, la rééducation physique peut aider à renforcer les muscles et améliorer la fonction."
}
},
{
"@type": "Question",
"name": "Les traitements sont-ils personnalisés ?",
"position": 20,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, les traitements sont souvent adaptés en fonction des besoins individuels du patient."
}
},
{
"@type": "Question",
"name": "Quelles complications peuvent survenir ?",
"position": 21,
"acceptedAnswer": {
"@type": "Answer",
"text": "Des complications incluent des troubles respiratoires et des crises musculaires."
}
},
{
"@type": "Question",
"name": "L'inhibition peut-elle entraîner des hospitalisations ?",
"position": 22,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, des cas graves peuvent nécessiter une hospitalisation pour surveillance."
}
},
{
"@type": "Question",
"name": "Y a-t-il un risque de décès ?",
"position": 23,
"acceptedAnswer": {
"@type": "Answer",
"text": "Dans des cas extrêmes, l'inhibition sévère peut entraîner des risques mortels."
}
},
{
"@type": "Question",
"name": "Les complications sont-elles réversibles ?",
"position": 24,
"acceptedAnswer": {
"@type": "Answer",
"text": "Certaines complications peuvent être réversibles avec un traitement approprié."
}
},
{
"@type": "Question",
"name": "Comment gérer les complications ?",
"position": 25,
"acceptedAnswer": {
"@type": "Answer",
"text": "La gestion des complications nécessite une approche multidisciplinaire et un suivi régulier."
}
},
{
"@type": "Question",
"name": "Quels sont les facteurs de risque d'inhibition ?",
"position": 26,
"acceptedAnswer": {
"@type": "Answer",
"text": "Les facteurs incluent des maladies auto-immunes, des infections et des antécédents familiaux."
}
},
{
"@type": "Question",
"name": "L'âge est-il un facteur de risque ?",
"position": 27,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, l'âge avancé est un facteur de risque pour les troubles de la libération d'acétylcholine."
}
},
{
"@type": "Question",
"name": "Les médicaments peuvent-ils influencer le risque ?",
"position": 28,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certains médicaments peuvent augmenter le risque d'inhibition d'acétylcholine."
}
},
{
"@type": "Question",
"name": "Le mode de vie affecte-t-il le risque ?",
"position": 29,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, un mode de vie sédentaire et une mauvaise alimentation peuvent augmenter le risque."
}
},
{
"@type": "Question",
"name": "Les infections virales sont-elles un risque ?",
"position": 30,
"acceptedAnswer": {
"@type": "Answer",
"text": "Oui, certaines infections virales peuvent déclencher des troubles de la libération d'acétylcholine."
}
}
]
}
]
}
Expert en Médecine, Optimisation des Parcours de Soins et Révision Médicale
Validation scientifique effectuée le 01/05/2025
Contenu vérifié selon les dernières recommandations médicales
3 publications dans cette catégorie
Affiliations :
Department of Pharmacology, School of Medicine, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Division of Genomic Science and Microbiology, School of Medicine, University of Fukui, Eiheiji, Fukui, Japan.
Kimura Hospital, Awara, Fukui, Japan.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
3 publications dans cette catégorie
Affiliations :
Department of Pharmacology, School of Medicine, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Division of Cellular Signal Transduction, Department of Biochemistry, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
3 publications dans cette catégorie
Affiliations :
Division of Genomic Science and Microbiology, School of Medicine, University of Fukui, Eiheiji, Fukui, Japan.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
3 publications dans cette catégorie
Affiliations :
Department of Pharmacology, School of Medicine, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
Division of Cellular Signal Transduction, Department of Biochemistry, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
Division of Cellular Signal Transduction, Department of Biochemistry, Asahikawa Medical University, Asahikawa, Hokkaido, Japan.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
Department of Pharmacology, School of Medicine, Kanazawa Medical University, Uchinada, Ishikawa, Japan.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
Department of Clinical Pharmacology, School of Medicine, Tokai University, Isehara 259-1193, Japan.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
Tokyo Dental College, Misaki-cho, Chiyoda-ku, Tokyo 101-0061, Japan.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
Department of Molecular Neuroimmune Signaling, Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, Russia (D.S.L., E.V.K., I.A.I., N.S.E., N.D.T., E.N.S., E.Y.T., A.E.S., D.S.K., I.E.K., V.I.T.); Department of Neurobiology, Hellenic Pasteur Institute, Athens, Greece (M.Z., S.J.T.); Institute of Molecular Medicine, Sechenov First Moscow State Medical University, Moscow, Russia (I.E.K.); Institute of Chemistry and Molecular Engineering, Agricultural University of Georgia, Kakha Bendukidze University Campus, Tbilisi, Georgia (R.K., N.Z., I.I.); and PhysBio of MePhI, Moscow, Russia (V.I.T.) victortsetlin3f@gmail.com.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 564-8565, Japan. Electronic address: torukawa@ncvc.go.jp.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
Department of Cardiac Physiology, National Cerebral and Cardiovascular Center, Osaka 564-8565, Japan.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
Department of Cardiac Physiology, National Cerebral and Cardiovascular Center, Osaka 564-8565, Japan.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
Department of Cardiac Physiology, National Cerebral and Cardiovascular Center, Osaka 564-8565, Japan.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
Department of Cardiovascular Dynamics, National Cerebral and Cardiovascular Center, Osaka 564-8565, Japan.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
Kazan Institute of Biochemistry and Biophysics FRC Kazan Scientific Center of RAS, PB 30, Kazan 420111, Russia. Electronic address: ellyab@mail.ru.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
Department of Physiology and Pharmacology, Wake Forest School of Medicine, Winston-Salem, North Carolina, USA.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
a Department of Pharmacy , Peking University People's Hospital , Beijing 100730 , China.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
2 publications dans cette catégorie
Affiliations :
b Beijing Key Laboratory of Drug Clinical Risk and Personalized Medication Evaluation, Department of Clinical Pharmacology , Beijing Hospital , Bejing 100044 , China.
Publications dans "Inhibiteurs de la libération d'acétylcholine" :
The role of bronchial provocation tests in the diagnosis of asthma remains to be fully explored. We aimed to evaluate methacholine and mannitol challenge testing, and explore the factors associated wi...
Observational, cross-over, randomized trial evaluating adult cases with suspected asthma, naïve to treatment, with normal pre-bronchodilator spirometry, and negative bronchodilator test. Patients were...
The study included 108 cases (50.0% diagnosed with asthma and 51.9% cases starting with methacholine). The percentage of cases positive to methacholine and mannitol were 30.6% and 25.0% respectively. ...
Our study confirms the diagnostic profile of methacholine and mannitol challenge tests and describes the variable associated to their positivity with new proposed cutoff values....
The allergen provocation test is an established model of allergic airway diseases, including asthma and allergic rhinitis, allowing the study of allergen-induced changes in respiratory physiology and ...
Oral provocation tests involve the supervised administration of suspected foods in increasing doses to evaluate a patient's allergic condition. Acknowledged as the superior method for diagnosing food ...
Inhaled mannitol provokes bronchoconstriction...
Participants with a clinical diagnosis of asthma, or undergoing investigation for suspected asthma, were recruited. Inhaled mannitol challenges were performed, followed by a sham challenge after 2 wee...
Forty-six patients (mean (SD) age 52 (16) years) completed a mannitol challenge, of which 16 (35%) were positive, and 15 of these completed a sham challenge. Quantities of 16 of 51 identified VOCs cha...
Inhalation of mannitol was associated with changes in breath VOCs, and in people with BHR resulted in a distinct exhaled breath profile when compared with a sham challenge. These differentially expres...
The aim of this study was to examine lung function, bronchial hyperresponsiveness (BHR) and exercise-induced respiratory symptoms in elite athletes performing different sports. Norwegian national-team...
Chest tightness-variant asthma (CTVA) is a novel atypical asthma characterized by chest tightness as the sole or primary symptom....
To investigate the value of bronchial provocation testing combined with fractional exhaled nitric oxide (FeNO) in the diagnosis of CTVA in children....
This study included 95 children aged 6-14 years with chest tightness as the sole symptom, with a duration of symptoms exceeding 4 weeks. All subjects underwent FeNO measurement, pulmonary function tes...
The lung function of children in both groups was normal. The FeNO level in the CTVA group was (22.35 ± 9.91) ppb, significantly higher than the control group (14.85 ± 5.63) ppb, with a statistically s...
FeNO can serve as an adjunctive diagnostic tool for CTVA, with the optimal cutoff point for diagnosing CTVA being 18.5 ppb. However, FeNO is not a specific diagnostic marker for CTVA and should be use...
There is currently no standardized duration of drug provocation test (DPT) for confirming/delabeling beta-lactam hypersensitivity reaction (BL-HSR)....
This meta-analysis and systematic review aimed to investigate the added diagnostic value of extended-day over single-day DPT for confirming/delabeling BL-HSR in adults and children....
The MEDLINE, EMBASE, Web of Science, and CINAHL online databases were searched from inception to 15 March 2023 for studies that performed extended-day DPT to confirm/delabel BL-HSR. Risk difference an...
A total of 10,371 DPTs from 42 studies were included. Extended-day DPTs ranged from 2-7 days, or as long as index reactions were reported (maximum 10 days). The overall prevalence of confirmed BL-HSR ...
The increased prevalence of confirmed BL-HSR observed during extended-day DPT could be attributed to the first-day DPT. As a results, our findings do not conclusively support the use of extended-day D...
The purpose is to assess the diagnostic accuracy of a provocative test coined as the 'posterior compression test' (PCT) in those with the suspected posterior labral tear or lesion....
A total of 515 'arthroscopic labral repairs' were identified between April 2013 and September 2020. Excluding those with concomitant shoulder pathologies, and only including those with pre-operative d...
When the PCT was performed for the isolated posterior labral tears, the sensitivity was 92.6% with the specificity of 86.5%. The positive predictive value and negative predictive value were 71.4-97%, ...
The posterior compression test correlated well with the arthroscopic diagnoses in a subset of patients with suspected posterior labral pathology, possibly by means of direct stimulation....
III; Diagnostic Study....
Diagnostic of aspirin (ASA) hypersensitivity is largely based on provocation tests. However, they have significant limitations including influence of medications, necessity of hospitalization, and saf...
The study group comprised 148 adult patients with suspicion of aspirin hypersensitivity, including 51 (36%) with chronic urticaria, 73 (51%) with asthma, and 55 (39%) with chronic sinusitis. The contr...
Out of 148 study group participants, 114 underwent BAT and ASA provocation with conclusive results acquired in both tests. In this group, the threshold for positive BAT was 4.9%. Sensitivity and speci...
Despite significant advantages of BAT such as safety, no influence of drugs, and objectivity, its performance makes it inferior to current standard in ASA hypersensitivity....
Airway hyperresponsiveness (AHR) is commonly assessed by a methacholine challenge test (MCT), during which a provocative concentration causing a 20% reduction in forced expiratory volume in 1 second (...
We analysed the changes in spirometry, lung volumes and sGaw during MCT in 211 randomly selected patients being evaluated for AHR to support a clinical diagnosis of asthma....
The mean (SD) age of the group was 53 (15) years, with 141 women (67%). Overall lung function was normal, with FEV...
Changes in sGaw during MCT indicate clinically significant AHR in support of a clinical diagnosis of asthma among patients being evaluated for asthma....