Is the humoral immunity dispensable for the pathogenesis of psoriasis?
Journal
Journal of the European Academy of Dermatology and Venereology : JEADV
ISSN: 1468-3083
Titre abrégé: J Eur Acad Dermatol Venereol
Pays: England
ID NLM: 9216037
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
07
02
2018
accepted:
23
05
2018
pubmed:
2
6
2018
medline:
11
5
2019
entrez:
2
6
2018
Statut:
ppublish
Résumé
Imbalances of T-cell subsets are hallmarks of disease-specific inflammation in psoriasis. However, the relevance of B cells for psoriasis remains poorly investigated. To analyse the role of B cells and immunoglobulins for the disease-specific immunology of psoriasis. We characterized B-cell subsets and immunoglobulin levels in untreated psoriasis patients (n = 37) and compared them to healthy controls (n = 20) as well as to psoriasis patients under disease-controlling systemic treatment (n = 28). B-cell subsets were analysed following the flow cytometric gating strategy based on the surface markers CD24, CD38 and CD138. Moreover, immunofluorescence stainings were used to detect IgA in psoriatic skin. We found significantly increased levels of IgA in the serum of treatment-naïve psoriasis patients correlating with disease score. However, IgA was only observed in dermal vessels of skin sections. Concerning B-cell subsets, we only found a moderately positive correlation of CD138 B-cell alterations might rather be an epiphenomenal finding in psoriasis with a clear dominance of T cells over shifts in B-cell subsets.
Sections du résumé
BACKGROUND
Imbalances of T-cell subsets are hallmarks of disease-specific inflammation in psoriasis. However, the relevance of B cells for psoriasis remains poorly investigated.
OBJECTIVE
To analyse the role of B cells and immunoglobulins for the disease-specific immunology of psoriasis.
METHODS
We characterized B-cell subsets and immunoglobulin levels in untreated psoriasis patients (n = 37) and compared them to healthy controls (n = 20) as well as to psoriasis patients under disease-controlling systemic treatment (n = 28). B-cell subsets were analysed following the flow cytometric gating strategy based on the surface markers CD24, CD38 and CD138. Moreover, immunofluorescence stainings were used to detect IgA in psoriatic skin.
RESULTS
We found significantly increased levels of IgA in the serum of treatment-naïve psoriasis patients correlating with disease score. However, IgA was only observed in dermal vessels of skin sections. Concerning B-cell subsets, we only found a moderately positive correlation of CD138
CONCLUSION
B-cell alterations might rather be an epiphenomenal finding in psoriasis with a clear dominance of T cells over shifts in B-cell subsets.
Substances chimiques
Immunoglobulin A
0
Syndecan-1
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
115-122Subventions
Organisme : Helmholtz Association
Pays : International
Organisme : German Research Foundation Deutsche Forschungsgemeinschaft
Pays : International
Organisme : European Research Council
Pays : International
Commentaires et corrections
Type : ErratumIn
Informations de copyright
© 2018 European Academy of Dermatology and Venereology.