Genetic immune and inflammatory markers associated with diabetes in solid organ transplant recipients.

Adolescent Adult Aged Diabetes Mellitus / etiology Female Gene-Environment Interaction Heterozygote Homozygote Humans Immunosuppression Therapy Immunosuppressive Agents / therapeutic use Inflammation / genetics Male Middle Aged Odds Ratio Organ Transplantation Polymorphism, Single Nucleotide Prospective Studies Switzerland / epidemiology Transplant Recipients Young Adult
clinical research/practice diabetes genetics new onset/posttransplant

Journal

American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons
ISSN: 1600-6143
Titre abrégé: Am J Transplant
Pays: United States
ID NLM: 100968638

Informations de publication

Date de publication:
01 2019
Historique:
received: 22 11 2017
revised: 07 06 2018
accepted: 08 06 2018
pubmed: 20 6 2018
medline: 17 4 2020
entrez: 20 6 2018
Statut: ppublish

Résumé

New-onset diabetes mellitus after transplantation (NODAT) is a complication following solid organ transplantation (SOT) and may be related to immune or inflammatory responses. We investigated whether single nucleotide polymorphisms (SNPs) within 158 immune- or inflammation-related genes contribute to NODAT in SOT recipients. The association between 263 SNPs and NODAT was investigated in a discovery sample of SOT recipients from the Swiss Transplant Cohort Study (STCS, n

Identifiants

DOI: 10.1111/ajt.14971 PMID: 29920932
pubmed: 29920932
doi: 10.1111/ajt.14971
pii: S1600-6135(22)08915-8
doi:

Substances chimiques

Immunosuppressive Agents 0

Types de publication

Journal Article Multicenter Study Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

238-246

Subventions

Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 31003A-143914
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 320030-120686
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 320030-173211
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 32003B-127613
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 3200B0-118308
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 3200B0-105993
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 324730-144054
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 324730-144064
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 33CS30-139468
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 33CS30-148401
Pays : International
Organisme : Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung
ID : 33CSCO-122661
Pays : International
Organisme : Foundation lausannoise de Transplantation d'organes
Pays : International
Organisme : Mérieux research grant
Pays : International
Organisme : Leenaards Foundation
Pays : International
Organisme : Roche Organ Transplantation Research Foundation
ID : 152358701
Pays : International
Organisme : GlaxoSmithKline
Pays : International
Organisme : Swiss National Research Foundation
ID : 320030-120686
Pays : International
Organisme : Swiss National Research Foundation
ID : 324730-144064
Pays : International
Organisme : Swiss National Research Foundation
ID : 320030-173211
Pays : International
Organisme : Swiss National Research Foundation
ID : 32003B_127613
Pays : International
Organisme : Swiss National Research Foundation
ID : 324730_144054
Pays : International
Organisme : Swiss National Research Foundation
ID : 3200B0-105993
Pays : International
Organisme : Santos-Suarez foundation
Pays : International
Organisme : Swiss National Foundation
Pays : International
Organisme : Faculty of Biology and Medicine of Lausanne
Pays : International

Informations de copyright

© 2018 The American Society of Transplantation and the American Society of Transplant Surgeons.

Auteurs

Lina Quteineh (L)

Unit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.

Agnieszka Wójtowicz (A)

Service of Infectious Diseases, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

Pierre-Yves Bochud (PY)

Service of Infectious Diseases, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

Severine Crettol (S)

Unit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.

Frederik Vandenberghe (F)

Unit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.

Jean-Pierre Venetz (JP)

Transplantation Center, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

Oriol Manuel (O)

Service of Infectious Diseases, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Transplantation Center, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

Dela Golshayan (D)

Transplantation Center, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

Roger Lehmann (R)

Service of Endocrinology and Diabetes, University Hospital, Zurich, Switzerland.

Nicolas J Mueller (NJ)

Division of Infectious Diseases and Hospital Epidemiology, University Hospital, Zurich, Switzerland.

Isabelle Binet (I)

Service of Nephrology and Transplantation Medicine, Kantonsspital, St Gallen, Switzerland.

Christian van Delden (C)

Service of Infectious Diseases, University Hospitals, Geneva, Switzerland.

Jürg Steiger (J)

Service of Nephrology, University Hospital, Basel, Switzerland.

Paul Mohacsi (P)

Swiss Cardiovascular Center Bern, University Hospital, Bern, Switzerland.

Jean-Francois Dufour (JF)

Department of Clinical Pharmacology, University Hospital, Bern, Switzerland.

Paola M Soccal (PM)

Service of Pulmonary Medicine, University Hospital, Geneva, Switzerland.

Zoltan Kutalik (Z)

Institute of Social and Preventive Medicine (IUMSP), Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.
Swiss Institute of Bioinformatics, Lausanne, Switzerland.

Pedro Marques-Vidal (P)

Department of Medicine, Internal Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

Peter Vollenweider (P)

Department of Medicine, Internal Medicine, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

Mike Recher (M)

Clinic for Primary Immunodeficiency and Immunodeficiency Laboratory, Department of Biomedicine, University Hospital, Basel, Switzerland.

Christoph Hess (C)

Department of Biomedicine, University Hospital, Basel, Switzerland.

Manuel Pascual (M)

Transplantation Center, Lausanne University Hospital, University of Lausanne, Lausanne, Switzerland.

Chin B Eap (CB)

Unit of Pharmacogenetics and Clinical Psychopharmacology, Department of Psychiatry, Lausanne University Hospital, University of Lausanne, Prilly, Switzerland.
School of Pharmaceutical Sciences, University of Geneva, University of Lausanne, Geneva, Switzerland.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adolescent › Genetic immune and inflammatory markers...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Genetic immune and inflammatory markers...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › Genetic immune and inflammatory markers...
questionsmedicales.fr › Maladies endocriniennes › Diabète › Genetic immune and inflammatory markers...
questionsmedicales.fr › Phénomènes génétiques › Phénotype › Interaction entre gènes et environnement › Genetic immune and inflammatory markers...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Hétérozygote › Genetic immune and inflammatory markers...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Homozygote › Genetic immune and inflammatory markers...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Genetic immune and inflammatory markers...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunosuppression thérapeutique › Genetic immune and inflammatory markers...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Immunosuppresseurs › Genetic immune and inflammatory markers...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Genetic immune and inflammatory markers...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › Genetic immune and inflammatory markers...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Statistiques comme sujet › Probabilité › Odds ratio › Genetic immune and inflammatory markers...
questionsmedicales.fr › Procédures de chirurgie opératoire › Transplantation › Transplantation d'organe › Genetic immune and inflammatory markers...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Genetic immune and inflammatory markers...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études de cohortes › Études prospectives › Genetic immune and inflammatory markers...
questionsmedicales.fr › Régions géographiques › Europe › Suisse › Genetic immune and inflammatory markers...
questionsmedicales.fr › Personnes › Receveurs de transplantation › Genetic immune and inflammatory markers...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Jeune adulte › Genetic immune and inflammatory markers...