Evolution of MHC class I genes in Eurasian badgers, genus Meles (Carnivora, Mustelidae).
Journal
Heredity
ISSN: 1365-2540
Titre abrégé: Heredity (Edinb)
Pays: England
ID NLM: 0373007
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
06
04
2018
accepted:
30
05
2018
revised:
30
05
2018
pubmed:
1
7
2018
medline:
8
5
2020
entrez:
1
7
2018
Statut:
ppublish
Résumé
Because of their role in immune defense against pathogens, major histocompatibility complex (MHC) genes are useful in evolutionary studies on how wild vertebrates adapt to their environments. We investigated the molecular evolution of MHC class I (MHCI) genes in four closely related species of Eurasian badgers, genus Meles. All four species of badgers showed similarly high variation in MHCI sequences compared to other Carnivora. We identified 7-21 putatively functional MHCI sequences in each of the badger species, and 2-7 sequences per individual, indicating the existence of 1-4 loci. MHCI exon 2 and 3 sequences encoding domains α1 and α2 exhibited different clade topologies in phylogenetic networks. Non-synonymous nucleotide substitutions at codons for antigen-binding sites exceeded synonymous substitutions for domain α1 but not for domain α2, suggesting that the domains α1 and α2 likely had different evolutionary histories in these species. Positive selection and recombination seem to have shaped the variation in domain α2, whereas positive selection was dominant in shaping the variation in domain α1. In the separate phylogenetic analyses for exon 2, exon 3, and intron 2, each showed three clades of Meles alleles, with rampant trans-species polymorphism, indicative of the long-term maintenance of ancestral MHCI polymorphism by balancing selection.
Identifiants
pubmed: 29959426
doi: 10.1038/s41437-018-0100-3
pii: 10.1038/s41437-018-0100-3
pmc: PMC6327056
doi:
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
205-218Subventions
Organisme : Japan Society for the Promotion of Science (JSPS)
ID : Joint Research Project Grant
Pays : International
Organisme : Russian Foundation for Basic Research (RFBR)
ID : 16-54-50004
Pays : International
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