Efflux pumps and antimicrobial resistance: Paradoxical components in systems genomics.
ATP binding cassette
Antimicrobial peptides
Drug resistance
Efflux pumps
Inflammation
Systems biology
Journal
Progress in biophysics and molecular biology
ISSN: 1873-1732
Titre abrégé: Prog Biophys Mol Biol
Pays: England
ID NLM: 0401233
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
01
06
2018
revised:
10
07
2018
accepted:
15
07
2018
pubmed:
22
7
2018
medline:
24
5
2019
entrez:
22
7
2018
Statut:
ppublish
Résumé
Efflux pumps play a major role in the increasing antimicrobial resistance rendering a large number of drugs of no use. Large numbers of pathogens are becoming multidrug resistant due to inadequate dosage and use of the existing antimicrobials. This leads to the need for identifying new efflux pump inhibitors. Design of novel targeted therapies using inherent complexity involved in the biological network modeling has gained increasing importance in recent times. The predictive approaches should be used to determine antimicrobial activities with high pathogen specificity and microbicidal potency. Antimicrobial peptides, which are part of our innate immune system, have the ability to respond to infections and have gained much attention in making resistant strain sensitive to existing drugs. In this review paper, we outline evidences linking host-directed therapy with the efflux pump activity to infectious disease.
Identifiants
pubmed: 30031023
pii: S0079-6107(18)30139-1
doi: 10.1016/j.pbiomolbio.2018.07.008
pmc: PMC7173168
pii:
doi:
Substances chimiques
Anti-Infective Agents
0
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
15-24Informations de copyright
Copyright © 2018 Elsevier Ltd. All rights reserved.
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