Discovery of Tricyclic Triazolo- and Imidazopyridine Lactams as M

Allosteric Regulation / drug effects Animals Drug Discovery / methods Humans Imidazoles / chemistry Lactams / chemistry Mice Muscarinic Agonists / chemistry Pyridines / chemistry Rats Receptor, Muscarinic M1 / agonists
CNS M1 PAM Positive allosteric modulator SAR muscarinic acetylcholine receptor 1

Journal

ACS chemical neuroscience
ISSN: 1948-7193
Titre abrégé: ACS Chem Neurosci
Pays: United States
ID NLM: 101525337

Informations de publication

Date de publication:
20 03 2019
Historique:
pubmed: 8 8 2018
medline: 7 3 2020
entrez: 8 8 2018
Statut: ppublish

Résumé

This Letter describes the chemical optimization of a new series of muscarinic acetylcholine receptor subtype 1 (M

Identifiants

DOI: 10.1021/acschemneuro.8b00311 PMID: 30086237 PMC: PMC6456254
pubmed: 30086237
doi: 10.1021/acschemneuro.8b00311
pmc: PMC6456254
mid: NIHMS1017209
doi:

Substances chimiques

Imidazoles 0
Lactams 0
Muscarinic Agonists 0
Pyridines 0
Receptor, Muscarinic M1 0
imidazopyridine 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

1035-1042

Subventions

Organisme : NIA NIH HHS
ID : R01 AG051626
Pays : United States
Organisme : NIMH NIH HHS
ID : R01 MH082867
Pays : United States
Organisme : NIMH NIH HHS
ID : U19 MH106839
Pays : United States
Organisme : NICHD NIH HHS
ID : U54 HD083211
Pays : United States

Références

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Auteurs

Julie L Engers (JL)

Vanderbilt Center for Neuroscience Drug Discovery , Vanderbilt University Medical Center , Nashville , Tennessee 37232 , United States.
Department of Pharmacology , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.

Aaron M Bender (AM)

Vanderbilt Center for Neuroscience Drug Discovery , Vanderbilt University Medical Center , Nashville , Tennessee 37232 , United States.
Department of Pharmacology , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.

Jacob J Kalbfleisch (JJ)

Vanderbilt Center for Neuroscience Drug Discovery , Vanderbilt University Medical Center , Nashville , Tennessee 37232 , United States.

Hyekyung P Cho (HP)

Vanderbilt Center for Neuroscience Drug Discovery , Vanderbilt University Medical Center , Nashville , Tennessee 37232 , United States.
Department of Pharmacology , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.

Kaelyn S Lingenfelter (KS)

Vanderbilt Center for Neuroscience Drug Discovery , Vanderbilt University Medical Center , Nashville , Tennessee 37232 , United States.

Vincent B Luscombe (VB)

Vanderbilt Center for Neuroscience Drug Discovery , Vanderbilt University Medical Center , Nashville , Tennessee 37232 , United States.

Changho Han (C)

Vanderbilt Center for Neuroscience Drug Discovery , Vanderbilt University Medical Center , Nashville , Tennessee 37232 , United States.
Department of Pharmacology , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.

Bruce J Melancon (BJ)

Vanderbilt Center for Neuroscience Drug Discovery , Vanderbilt University Medical Center , Nashville , Tennessee 37232 , United States.
Department of Pharmacology , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.
Warren Family Research Center for Drug Discovery & Development , University of Notre Dame , Notre Dame , Indiana 46556 , United States.

Anna L Blobaum (AL)

Vanderbilt Center for Neuroscience Drug Discovery , Vanderbilt University Medical Center , Nashville , Tennessee 37232 , United States.
Department of Pharmacology , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.

Jonathan W Dickerson (JW)

Vanderbilt Center for Neuroscience Drug Discovery , Vanderbilt University Medical Center , Nashville , Tennessee 37232 , United States.
Department of Pharmacology , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.

Jerri M Rook (JM)

Vanderbilt Center for Neuroscience Drug Discovery , Vanderbilt University Medical Center , Nashville , Tennessee 37232 , United States.
Department of Pharmacology , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.

Colleen M Niswender (CM)

Vanderbilt Center for Neuroscience Drug Discovery , Vanderbilt University Medical Center , Nashville , Tennessee 37232 , United States.
Department of Pharmacology , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.
Vanderbilt Kennedy Center , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.

Kyle A Emmitte (KA)

Vanderbilt Center for Neuroscience Drug Discovery , Vanderbilt University Medical Center , Nashville , Tennessee 37232 , United States.
Department of Pharmacology , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.
Department of Chemistry , Vanderbilt University , Nashville , Tennessee 37232 , United States.
ORCID: 0000-0002-6643-3947

P Jeffrey Conn (PJ)

Vanderbilt Center for Neuroscience Drug Discovery , Vanderbilt University Medical Center , Nashville , Tennessee 37232 , United States.
Department of Pharmacology , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.
Vanderbilt Kennedy Center , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.

Craig W Lindsley (CW)

Vanderbilt Center for Neuroscience Drug Discovery , Vanderbilt University Medical Center , Nashville , Tennessee 37232 , United States.
Department of Pharmacology , Vanderbilt University School of Medicine , Nashville , Tennessee 37232 , United States.
Department of Chemistry , Vanderbilt University , Nashville , Tennessee 37232 , United States.
Department of Biochemistry , Vanderbilt University , Nashville , Tennessee 37232 , United States.
ORCID: 0000-0003-0168-1445

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Régulation allostérique › Discovery of Tricyclic Triazolo- and...
questionsmedicales.fr › Eucaryotes › Animaux › Discovery of Tricyclic Triazolo- and...
questionsmedicales.fr › Techniques d'investigation › Développement de médicament › Découverte de médicament › Discovery of Tricyclic Triazolo- and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Discovery of Tricyclic Triazolo- and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Discovery of Tricyclic Triazolo- and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Lactames › Discovery of Tricyclic Triazolo- and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Souris › Discovery of Tricyclic Triazolo- and...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Agents neuromédiateurs › Agents cholinergiques › Agonistes cholinergiques › Agonistes muscariniques › Discovery of Tricyclic Triazolo- and...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Pyridines › Discovery of Tricyclic Triazolo- and...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Rodentia › Muridae › Murinae › Rats › Discovery of Tricyclic Triazolo- and...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Récepteurs de surface cellulaire › Récepteurs aux neuromédiateurs › Récepteurs cholinergiques › Récepteur muscarinique › Récepteur muscarinique de type M1 › Discovery of Tricyclic Triazolo- and...