S,S-Chiral Linker Induced U Shape with a Syn-facial Sensitizer and Photocleavable Ethene Group.
Journal
Photochemistry and photobiology
ISSN: 1751-1097
Titre abrégé: Photochem Photobiol
Pays: United States
ID NLM: 0376425
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
17
06
2018
accepted:
06
08
2018
pubmed:
17
8
2018
medline:
2
5
2019
entrez:
17
8
2018
Statut:
ppublish
Résumé
There is a major need for light-activated materials for the release of sensitizers and drugs. Considering the success of chiral columns for the separation of enantiomer drugs, we synthesized an S,S-chiral linker system covalently attached to silica with a sensitizer ethene near the silica surface. First, the silica surface was modified to be aromatic rich, by replacing 70% of the surface groups with (3-phenoxypropyl)silane. We then synthesized a 3-component conjugate [chlorin sensitizer, S,S-chiral cyclohexane and ethene building blocks] in 5 steps with a 13% yield, and covalently bound the conjugate to the (3-phenoxypropyl)silane-coated silica surface. We hypothesized that the chiral linker would increase exposure of the ethene site for enhanced
Identifiants
pubmed: 30113068
doi: 10.1111/php.13000
pmc: PMC6347524
mid: NIHMS997411
doi:
Substances chimiques
Ethylenes
0
Photosensitizing Agents
0
ethylene
91GW059KN7
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Langues
eng
Sous-ensembles de citation
IM
Pagination
293-305Subventions
Organisme : Natural Sciences and Engineering Council of Canada
Pays : International
Organisme : Beatrice Hunter Cancer Research Institute
Pays : International
Organisme : the Canadian Institutes of Health Research
Pays : International
Organisme : Eugene Lang Foundation at Baruch College
Pays : International
Organisme : Natural Sciences and Engineering Council of Canada
Pays : International
Organisme : NCI NIH HHS
ID : R01 CA222227
Pays : United States
Organisme : Agencia de Promoción Científica y Tecnológica
Pays : International
Organisme : the Canadian Foundation for Innovation
Pays : International
Organisme : the Nova Scotia Research
Pays : International
Organisme : Consejo Nacional de Investigaciones Cientıficas y Tecnicas (CONICET)
Pays : International
Organisme : Innovation Trust
Pays : International
Organisme : University of North Carolina at Greensboro
Pays : International
Organisme : Petroleum Research Fund
Pays : International
Organisme : National Science Foundation
ID : ACI01053575
Pays : International
Organisme : Acadia University
Pays : International
Organisme : National Science Foundation
ID : CHE-1464975
Pays : International
Informations de copyright
© 2018 The American Society of Photobiology.
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