Harnessing CRISPR/Cas 9 System for manipulation of DNA virus genome.

CRISPR-Associated Protein 9 / metabolism Clustered Regularly Interspaced Short Palindromic Repeats DNA Viruses / genetics Gene Editing / methods Recombination, Genetic
CAS9 CRISPR-CAS system DNA Viruses Gene Editing

Journal

Reviews in medical virology
ISSN: 1099-1654
Titre abrégé: Rev Med Virol
Pays: England
ID NLM: 9112448

Informations de publication

Date de publication:
01 2019
Historique:
received: 16 04 2018
revised: 03 08 2018
accepted: 07 08 2018
pubmed: 28 9 2018
medline: 26 3 2019
entrez: 28 9 2018
Statut: ppublish

Résumé

The recent development of the Clustered Regularly Interspaced Palindromic Repeat (CRISPR)/CRISPR-associated protein 9 (Cas9) system, a genome editing system, has many potential applications in virology. The possibility of introducing site specific breaks has provided new possibilities to precisely manipulate viral genomics. Here, we provide diagrams to summarize the steps involved in the process. We also systematically review recent applications of the CRISPR/Cas9 system for manipulation of DNA virus genomics and discuss the therapeutic potential of the system to treat viral diseases.

Identifiants

DOI: 10.1002/rmv.2009 PMID: 30260068
pubmed: 30260068
doi: 10.1002/rmv.2009
doi:

Substances chimiques

CRISPR-Associated Protein 9 EC 3.1.-

Types de publication

Journal Article Review

Langues

eng

Sous-ensembles de citation

IM

Pagination

e2009

Informations de copyright

© 2018 John Wiley & Sons, Ltd.

Auteurs

Saeedeh Ebrahimi (S)

Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Virology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

Ali Teimoori (A)

Infectious and Tropical Diseases Research Center, Health Research Institute, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
Department of Virology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
ORCID: 0000-0001-9037-7757

Hashem Khanbabaei (H)

Medical Physics Department, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.
ORCID: 0000-0002-4442-9605

Maryam Tabasi (M)

Department of Virology, Faculty of Medicine, Ahvaz Jundishapur University of Medical Sciences, Ahvaz, Iran.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines associées aux CRISPR › Protéine-9 associée à CRISPR › Harnessing CRISPR/Cas 9 System for...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Séquences répétées en tandem › Clustered regularly interspaced short palindromic repeats › Harnessing CRISPR/Cas 9 System for...
questionsmedicales.fr › Virus › Virus à ADN › Harnessing CRISPR/Cas 9 System for...
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Génie génétique › Édition de gène › Harnessing CRISPR/Cas 9 System for...
questionsmedicales.fr › Phénomènes génétiques › Recombinaison génétique › Harnessing CRISPR/Cas 9 System for...