Invasive Curvularia Infection in Pediatric Patients With Hematologic Malignancy Identified by Fungal Sequencing.
Amphotericin B
/ therapeutic use
Antifungal Agents
/ therapeutic use
Ascomycota
/ isolation & purification
Child
Dermatomycoses
/ diagnosis
Female
Humans
Immunocompromised Host
Male
Opportunistic Infections
/ diagnosis
Precursor B-Cell Lymphoblastic Leukemia-Lymphoma
/ immunology
Precursor Cell Lymphoblastic Leukemia-Lymphoma
/ immunology
Precursor T-Cell Lymphoblastic Leukemia-Lymphoma
/ immunology
RNA, Ribosomal, 28S
/ genetics
Sequence Analysis, DNA
Voriconazole
/ therapeutic use
Curvularia
fungal sequencing
leukemia
Journal
Journal of the Pediatric Infectious Diseases Society
ISSN: 2048-7207
Titre abrégé: J Pediatric Infect Dis Soc
Pays: England
ID NLM: 101586049
Informations de publication
Date de publication:
28 Mar 2019
28 Mar 2019
Historique:
received:
19
03
2018
accepted:
31
08
2018
pubmed:
29
9
2018
medline:
2
5
2019
entrez:
29
9
2018
Statut:
ppublish
Résumé
Curvularia is a saprophytic dematiaceous mold and a rare human pathogen. Here, we report three severely immunocompromised pediatric patients who developed invasive Curvularia infection. Diagnosis was achieved or confirmed in all cases by fungal ribosome sequencing, which hastened species identification and targeted treatment for the patients reported. There are no treatment guidelines for invasive Curvularia infection, though we report three patients who were cured of their infection through a combination of surgical resection and various anti-fungal therapies, indicating a relatively low virulence and good prognosis in comparison to other angioinvasive molds.
Identifiants
pubmed: 30265347
pii: 5108465
doi: 10.1093/jpids/piy092
doi:
Substances chimiques
Antifungal Agents
0
RNA, Ribosomal, 28S
0
Amphotericin B
7XU7A7DROE
Voriconazole
JFU09I87TR
Types de publication
Case Reports
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
87-91Informations de copyright
© The Author(s) 2018. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.