A novel genomic approach to herbicide and herbicide mode of action discovery.
genomics
herbicide
herbicide resistance
mode of action
natural phytotoxin
Journal
Pest management science
ISSN: 1526-4998
Titre abrégé: Pest Manag Sci
Pays: England
ID NLM: 100898744
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
27
07
2018
revised:
12
09
2018
accepted:
26
09
2018
pubmed:
4
10
2018
medline:
16
1
2019
entrez:
4
10
2018
Statut:
ppublish
Résumé
A herbicide with a new mode of action has not been commercialized for more than 30 years. A recent paper describes a novel genomic approach to herbicide and herbicide mode of action discovery. Analysis of a microbial gene cluster revealed that it encodes genes for both the biosynthetic pathway for production of the sesquiterpene aspterric acid and an aspterric acid-resistant form of dihydroxy acid dehydratase (DHAD), its target enzyme. Aspterric acid is weak compared with commercial synthetic herbicides, and whether DHAD is a good herbicide target is unclear from this study. Nevertheless, this genomic approach provides a novel strategy for the discovery of herbicides with new modes action. © 2018 Society of Chemical Industry.
Substances chimiques
Herbicides
0
Heterocyclic Compounds, 3-Ring
0
aspterric acid
67309-95-9
Hydro-Lyases
EC 4.2.1.-
dihydroxyacid dehydratase
EC 4.2.1.9
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
314-317Informations de copyright
© 2018 Society of Chemical Industry.