Enhancer Connectome Nominates Target Genes of Inherited Risk Variants from Inflammatory Skin Disorders.

Cell Differentiation Chromatin Chromatin Immunoprecipitation Connectome Enhancer Elements, Genetic / genetics Genetic Predisposition to Disease Genome-Wide Association Study Histones / genetics Humans Ikaros Transcription Factor / genetics Inflammation / genetics Interferon Regulatory Factors / genetics Janus Kinases / metabolism Lupus Erythematosus, Systemic / genetics Polymorphism, Single Nucleotide STAT Transcription Factors Signal Transduction Skin Diseases / genetics T-Lymphocytes, Regulatory / physiology Th17 Cells / physiology

Journal

The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720

Informations de publication

Date de publication:
03 2019
Historique:
received: 29 03 2018
revised: 24 08 2018
accepted: 18 09 2018
pubmed: 14 10 2018
medline: 25 2 2020
entrez: 14 10 2018
Statut: ppublish

Résumé

The vast majority of polymorphisms for human dermatologic diseases fall in noncoding DNA regions, leading to difficulty interpreting their functional significance. Recent work using chromosome conformation capture technology in combination with chromatin immunoprecipitation (ChIP) has provided a systematic means of linking noncoding variants in active enhancer loci to putative gene targets. Here, we apply H3K27ac HiChIP high-resolution contact maps, generated from primary human T-cell subsets (CD4

Identifiants

DOI: 10.1016/j.jid.2018.09.011 PMID: 30315781
pubmed: 30315781
pii: S0022-202X(18)32657-5
doi: 10.1016/j.jid.2018.09.011
pii:
doi:

Substances chimiques

Chromatin 0
Histones 0
Interferon Regulatory Factors 0
STAT Transcription Factors 0
interferon regulatory factor-8 0
Ikaros Transcription Factor 148971-36-2
Janus Kinases EC 2.7.10.2

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

605-614

Commentaires et corrections

Type : CommentIn

Informations de copyright

Copyright © 2018 The Authors. Published by Elsevier Inc. All rights reserved.

Auteurs

Mark Y Jeng (MY)

Department of Dermatology, Stanford University School of Medicine, Redwood City, California, USA.

Maxwell R Mumbach (MR)

Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California, USA; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.

Jeffrey M Granja (JM)

Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California, USA; Department of Genetics, Stanford University School of Medicine, Stanford, California, USA.

Ansuman T Satpathy (AT)

Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California, USA; Department of Pathology, Stanford University School of Medicine, Stanford, California, USA.

Howard Y Chang (HY)

Center for Personal Dynamic Regulomes, Stanford University School of Medicine, Stanford, California, USA; Program in Epithelial Biology, Stanford University School of Medicine, Stanford, California, USA.

Anne Lynn S Chang (ALS)

Department of Dermatology, Stanford University School of Medicine, Redwood City, California, USA. Electronic address: alschang@stanford.edu.

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Classifications MeSH

questionsmedicales.fr › Phénomènes physiologiques cellulaires › Différenciation cellulaire › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Structures de chromosome › Chromatine › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Techniques d'investigation › Techniques immunologiques › Immunoprécipitation › Immunoprécipitation de la chromatine › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Techniques d'investigation › Neuroimagerie › Neuroimagerie fonctionnelle › Cartographie cérébrale › Connectome › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Génome › Composants de génome › Gènes › Composants de gène › Éléments de régulation transcriptionnelle › Éléments activateurs (génétique) › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Phénomènes génétiques › Génotype › Prédisposition génétique à une maladie › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Épidémiologie moléculaire › Étude d'association pangénomique › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Nucléoprotéines › Histone › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription Krüppel-like › Facteur de transcription Ikaros › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de régulation d'interféron › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines et peptides de signalisation intracellulaire › Protein-tyrosine kinases › Janus kinases › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Maladies du système immunitaire › Maladies auto-immunes › Lupus érythémateux disséminé › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Phénomènes génétiques › Variation génétique › Polymorphisme génétique › Polymorphisme de nucléotide simple › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Facteurs de transcription › Facteurs de transcription STAT › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Phénomènes physiologiques cellulaires › Transduction du signal › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Maladies de la peau et du tissu conjonctif › Maladies de la peau › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T régulateurs › Enhancer Connectome Nominates Target Genes of...
questionsmedicales.fr › Systèmes sanguin et immunitaire › Système immunitaire › Leucocytes › Agranulocytes › Lymphocytes › Lymphocytes T › Sous-populations de lymphocytes T › Lymphocytes T auxiliaires › Cellules Th17 › Enhancer Connectome Nominates Target Genes of...