FK506 Resistance of

ATP-Binding Cassette Transporters / genetics Antifungal Agents / pharmacology Biological Transport / drug effects Candida albicans / drug effects Depsipeptides / pharmacology Drug Resistance, Fungal / genetics Fungal Proteins / genetics Membrane Transport Proteins / genetics Saccharomyces cerevisiae / drug effects Saccharomyces cerevisiae Proteins / genetics Tacrolimus / pharmacology
Candida albicans Cdr1 FK506 FK506 suppressor mutants PDR transporters Saccharomyces cerevisiae PDR5 efflux pump inhibition fungal efflux pumps

Journal

Antimicrobial agents and chemotherapy
ISSN: 1098-6596
Titre abrégé: Antimicrob Agents Chemother
Pays: United States
ID NLM: 0315061

Informations de publication

Date de publication:
01 2019
Historique:
received: 31 05 2018
accepted: 10 10 2018
pubmed: 24 10 2018
medline: 29 1 2020
entrez: 24 10 2018
Statut: epublish

Résumé

The 23-membered-ring macrolide tacrolimus, a commonly used immunosuppressant, also known as FK506, is a broad-spectrum inhibitor and an efflux pump substrate of pleiotropic drug resistance (PDR) ATP-binding cassette (ABC) transporters. Little, however, is known about the molecular mechanism by which FK506 inhibits PDR transporter drug efflux. Thus, to obtain further insights we searched for FK506-resistant mutants of

Identifiants

DOI: 10.1128/AAC.01146-18 PMID: 30348662 PMC: PMC6325234
pubmed: 30348662
pii: AAC.01146-18
doi: 10.1128/AAC.01146-18
pmc: PMC6325234
pii:
doi:

Substances chimiques

ATP-Binding Cassette Transporters 0
Antifungal Agents 0
CDR1 protein, Candida albicans 0
Depsipeptides 0
Fungal Proteins 0
Membrane Transport Proteins 0
PDR5 protein, S cerevisiae 0
Saccharomyces cerevisiae Proteins 0
enniatins 0
beauvericin 26S048LS2R
Tacrolimus WM0HAQ4WNM

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Informations de copyright

Copyright © 2018 American Society for Microbiology.

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Auteurs

Koichi Tanabe (K)

Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Tokyo, Japan.

Michele Bonus (M)

Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Susumu Tomiyama (S)

Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Tokyo, Japan.

Kunji Miyoshi (K)

Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Tokyo, Japan.

Minoru Nagi (M)

Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Tokyo, Japan.

Kyoko Niimi (K)

Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.

Ariya Chindamporn (A)

Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Holger Gohlke (H)

Institute of Pharmaceutical and Medicinal Chemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Lutz Schmitt (L)

Institute of Biochemistry, Heinrich Heine University Düsseldorf, Düsseldorf, Germany.

Richard D Cannon (RD)

Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.

Masakazu Niimi (M)

Department of Chemotherapy and Mycoses, National Institute of Infectious Diseases, Tokyo, Japan masa.niimi@otago.ac.nz erwin.lamping@otago.ac.nz.
Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand.
Department of Microbiology, Faculty of Medicine, Chulalongkorn University, Bangkok, Thailand.

Erwin Lamping (E)

Sir John Walsh Research Institute, Faculty of Dentistry, University of Otago, Dunedin, New Zealand masa.niimi@otago.ac.nz erwin.lamping@otago.ac.nz.

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Classifications MeSH

questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › Transporteurs ABC › FK506 Resistance of
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-infectieux › Antifongiques › FK506 Resistance of
questionsmedicales.fr › Métabolisme › Transport biologique › FK506 Resistance of
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Candida › Candida albicans › FK506 Resistance of
questionsmedicales.fr › Acides aminés, peptides et protéines › Peptides › Peptides cycliques › Depsipeptides › FK506 Resistance of
questionsmedicales.fr › Phénomènes physiologiques › Phénomènes pharmacologiques et toxicologiques › Phénomènes pharmacologiques › Résistance aux substances › Résistance microbienne aux médicaments › Résistance des champignons aux médicaments › FK506 Resistance of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › FK506 Resistance of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines membranaires › Protéines de transport membranaire › FK506 Resistance of
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › FK506 Resistance of
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines fongiques › Protéines de Saccharomyces cerevisiae › FK506 Resistance of
questionsmedicales.fr › Composés chimiques organiques › Lactones › Tacrolimus › FK506 Resistance of