Effect of disinfectant formulation and organic soil on the efficacy of oxidizing disinfectants against biofilms.
Biofilms
/ drug effects
Chlorine
/ pharmacology
Disinfectants
/ pharmacology
Drug Synergism
Environmental Microbiology
Hydrogen Peroxide
/ pharmacology
Microbial Viability
/ drug effects
Organic Chemicals
/ pharmacology
Oxidants
/ pharmacology
Peracetic Acid
/ pharmacology
Soil
Staphylococcus aureus
/ drug effects
Biofilms
Disinfectant efficacy
Disinfection
Dry hospital surfaces
Oxidizing disinfectants
Removing biofilms
Journal
The Journal of hospital infection
ISSN: 1532-2939
Titre abrégé: J Hosp Infect
Pays: England
ID NLM: 8007166
Informations de publication
Date de publication:
Sep 2019
Sep 2019
Historique:
received:
31
08
2018
accepted:
22
10
2018
pubmed:
6
11
2018
medline:
31
12
2019
entrez:
5
11
2018
Statut:
ppublish
Résumé
Biofilms that develop on dry surfaces in the healthcare environment have increased tolerance to disinfectants. This study compared the activity of formulated oxidizing disinfectants with products containing active ingredients against Staphylococcus aureus dry-surface biofilm (DSB) alone. DSB was grown in the CDC bioreactor with alternating cycles of hydration and dehydration. Disinfectant efficacy was tested before and after treatment with neutral detergent for 30 s, and in the presence or absence of standardized soil. Biofilms were treated for 5 min with peracetic acid (Surfex and Proxitane), hydrogen peroxide (Oxivir and 6% H Biofilm viability was reduced by 2.8 log The additives in fully formulated disinfectants can act synergistically with active ingredients, and thus increase biofilm killing whilst decreasing the adverse effect of soil. It is suggested that purchasing officers should seek efficacy testing results, and consider whether efficacy testing has been conducted in the presence of biological soil and/or biofilm.
Sections du résumé
BACKGROUND
BACKGROUND
Biofilms that develop on dry surfaces in the healthcare environment have increased tolerance to disinfectants. This study compared the activity of formulated oxidizing disinfectants with products containing active ingredients against Staphylococcus aureus dry-surface biofilm (DSB) alone.
METHODS
METHODS
DSB was grown in the CDC bioreactor with alternating cycles of hydration and dehydration. Disinfectant efficacy was tested before and after treatment with neutral detergent for 30 s, and in the presence or absence of standardized soil. Biofilms were treated for 5 min with peracetic acid (Surfex and Proxitane), hydrogen peroxide (Oxivir and 6% H
FINDINGS
RESULTS
Biofilm viability was reduced by 2.8 log
CONCLUSION
CONCLUSIONS
The additives in fully formulated disinfectants can act synergistically with active ingredients, and thus increase biofilm killing whilst decreasing the adverse effect of soil. It is suggested that purchasing officers should seek efficacy testing results, and consider whether efficacy testing has been conducted in the presence of biological soil and/or biofilm.
Identifiants
pubmed: 30391488
pii: S0195-6701(18)30556-5
doi: 10.1016/j.jhin.2018.10.019
pii:
doi:
Substances chimiques
Disinfectants
0
Organic Chemicals
0
Oxidants
0
Soil
0
Chlorine
4R7X1O2820
Hydrogen Peroxide
BBX060AN9V
Peracetic Acid
I6KPI2E1HD
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
e33-e41Informations de copyright
Copyright © 2018 The Authors. Published by Elsevier Ltd.. All rights reserved.