Imidazole-pyrazole hybrids: Synthesis, characterization and in-vitro bioevaluation against α-glucosidase enzyme with molecular docking studies.

Binding Sites Enzyme Assays Glycoside Hydrolase Inhibitors / chemical synthesis Imidazoles / chemical synthesis Molecular Docking Simulation Molecular Structure Pyrazoles / chemical synthesis Saccharomyces cerevisiae / enzymology alpha-Glucosidases / chemistry
Molecular modeling Multicomponent reactions Tetrasubstituted imidazoles α-Glucosidase inhibitors

Journal

Bioorganic chemistry
ISSN: 1090-2120
Titre abrégé: Bioorg Chem
Pays: United States
ID NLM: 1303703

Informations de publication

Date de publication:
02 2019
Historique:
received: 08 07 2018
revised: 27 09 2018
accepted: 23 10 2018
pubmed: 6 11 2018
medline: 31 8 2019
entrez: 6 11 2018
Statut: ppublish

Résumé

Herein, substituted imidazole-pyrazole hybrids (2a-2n) were prepared via a multi component reaction employing pyrazole-4-carbaldehydes (1a-1d), ammonium acetate, benzil and arylamines as reactants. All the new compounds were characterized through their spectral and elemental analyses. Further these compounds were tested against α-glucosidase enzyme. The compounds 2k, 2l and 2n possessed good inhibition potencies, however, compounds 2f (IC

Identifiants

DOI: 10.1016/j.bioorg.2018.10.047 PMID: 30396060
pubmed: 30396060
pii: S0045-2068(18)30679-5
doi: 10.1016/j.bioorg.2018.10.047
pii:
doi:

Substances chimiques

Glycoside Hydrolase Inhibitors 0
Imidazoles 0
Pyrazoles 0
alpha-Glucosidases EC 3.2.1.20

Types de publication

Journal Article Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Pagination

267-273

Informations de copyright

Copyright © 2018 Elsevier Inc. All rights reserved.

Auteurs

Faryal Chaudhry (F)

Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan; Department of Chemistry, Kinnaird College for Women, Lahore 54000, Pakistan. Electronic address: faryal.chaudhry@kinnaird.edu.pk.

Sadia Naureen (S)

Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan.

Muhammad Ashraf (M)

Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.

Mariya Al-Rashida (M)

Department of Chemistry, Forman Christian College (A Chartered University), Ferozepur Road, Lahore 54600, Pakistan.

Bakhat Jahan (B)

Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.

Munawar Ali Munawar (MA)

Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan. Electronic address: mamunawar.chem@pu.edu.pk.

Misbahul Ain Khan (MA)

Institute of Chemistry, University of the Punjab, Lahore 54590, Pakistan; Department of Chemistry, The Islamia University of Bahawalpur, Bahawalpur 63100, Pakistan.

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Classifications MeSH

questionsmedicales.fr › Phénomènes chimiques › Phénomènes biochimiques › Sites de fixation › Imidazole-pyrazole hybrids: Synthesis,...
questionsmedicales.fr › Techniques d'investigation › Techniques de chimie analytique › Dosages enzymatiques › Imidazole-pyrazole hybrids: Synthesis,...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Hypoglycémiants › Inhibiteurs des glycoside hydrolases › Imidazole-pyrazole hybrids: Synthesis,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Imidazoles › Imidazole-pyrazole hybrids: Synthesis,...
questionsmedicales.fr › Sciences de l'information › Méthodologies informatiques › Simulation numérique › Simulation de docking moléculaire › Imidazole-pyrazole hybrids: Synthesis,...
questionsmedicales.fr › Phénomènes chimiques › Structure moléculaire › Imidazole-pyrazole hybrids: Synthesis,...
questionsmedicales.fr › Composés hétérocycliques › Composés hétéromonocycliques › Azoles › Pyrazoles › Imidazole-pyrazole hybrids: Synthesis,...
questionsmedicales.fr › Eucaryotes › Champignons › Levures › Saccharomyces › Saccharomyces cerevisiae › Imidazole-pyrazole hybrids: Synthesis,...
questionsmedicales.fr › Enzymes et coenzymes › Enzymes › Hydrolases › Glycosidases › Glucosidases › alpha-Glucosidase › Imidazole-pyrazole hybrids: Synthesis,...