Carboxypeptidase in prolyl oligopeptidase family: Unique enzyme activation and substrate-screening mechanisms.
POP family
S9 peptidase
S9C subfamily
active site regulation
carboxypeptidase
catalytic triad
enzyme catalysis
oligomerization
oligopeptidase
peptidase
serine carboxypeptidase
structure-function
substrate screening
substrate specificity
Journal
The Journal of biological chemistry
ISSN: 1083-351X
Titre abrégé: J Biol Chem
Pays: United States
ID NLM: 2985121R
Informations de publication
Date de publication:
04 01 2019
04 01 2019
Historique:
received:
31
05
2018
revised:
02
11
2018
pubmed:
10
11
2018
medline:
10
4
2019
entrez:
10
11
2018
Statut:
ppublish
Résumé
Serine peptidases of the prolyl oligopeptidase (POP) family are of substantial therapeutic importance because of their involvement in diseases such as diabetes, cancer, neurological diseases, and autoimmune disorders. Proper annotation and knowledge of substrate specificity mechanisms in this family are highly valuable. Although endopeptidase, dipeptidyl peptidase, tripeptidyl peptidase, and acylaminoacyl peptidase activities have been reported previously, here we report the first instance of carboxypeptidase activity in a POP family member. We determined the crystal structures of this carboxypeptidase, an S9C subfamily member from
Identifiants
pubmed: 30409909
pii: S0021-9258(20)36882-4
doi: 10.1074/jbc.RA118.004254
pmc: PMC6322877
pii:
doi:
Substances chimiques
Bacterial Proteins
0
Serine Endopeptidases
EC 3.4.21.-
Prolyl Oligopeptidases
EC 3.4.21.26
Banques de données
PDB
['5YZM', '6IGP', '6IGQ', '5YZN', '5YZO', '6IGR', '6IKG', '4HXE', '4HXG', '1E8N']
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
89-100Informations de copyright
© 2019 Yadav et al.
Déclaration de conflit d'intérêts
The authors declare that they have no conflicts of interest with the contents of this article.
Références
Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):235-42
pubmed: 21460441
Acta Crystallogr D Biol Crystallogr. 2011 Apr;67(Pt 4):355-67
pubmed: 21460454
Nucleic Acids Res. 2014 Jan;42(Database issue):D503-9
pubmed: 24157837
Acta Crystallogr D Biol Crystallogr. 2010 Jan;66(Pt 1):12-21
pubmed: 20057044
Curr Protein Pept Sci. 2008 Feb;9(1):96-107
pubmed: 18336325
J Synchrotron Radiat. 2016 Mar;23(2):629-34
pubmed: 26917153
Anal Biochem. 1981 Nov 15;118(1):173-84
pubmed: 7039409
Structure. 2004 Aug;12(8):1481-8
pubmed: 15296741
J Lab Clin Med. 1992 Oct;120(4):546-52
pubmed: 1328432
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):213-21
pubmed: 20124702
Cell. 1998 Jul 24;94(2):161-70
pubmed: 9695945
Proteins. 1997 Jul;28(3):375-9
pubmed: 9223183
J Biol Chem. 1999 Apr 2;274(14):9246-52
pubmed: 10092598
Cell Mol Life Sci. 2002 Feb;59(2):349-62
pubmed: 11915948
Biochem Biophys Res Commun. 1986 Aug 29;139(1):244-50
pubmed: 3767956
J Comput Chem. 2004 Oct;25(13):1605-12
pubmed: 15264254
Acta Crystallogr F Struct Biol Commun. 2014 Sep;70(Pt 9):1292-5
pubmed: 25195912
J Biol Chem. 1987 Aug 25;262(24):11435-45
pubmed: 3305492
Life Sci. 1983 Nov 28;33(22):2149-57
pubmed: 6358755
Biochem J. 1976 Jul 1;157(1):169-82
pubmed: 962853
Protein Expr Purif. 2005 Apr;40(2):385-95
pubmed: 15766881
PLoS One. 2013 Nov 12;8(11):e79349
pubmed: 24265767
J Mol Biol. 2007 Sep 21;372(3):774-97
pubmed: 17681537
Biochemistry. 1999 Sep 7;38(36):11597-603
pubmed: 10512614
J Mol Biol. 1993 Oct 5;233(3):546-9
pubmed: 8411161
Proc Natl Acad Sci U S A. 2005 Mar 8;102(10):3599-604
pubmed: 15738423
Biochemistry. 2011 May 31;50(21):4402-10
pubmed: 21506553
J Biol Chem. 2014 Mar 28;289(13):9039-52
pubmed: 24554718
J Biol Chem. 2013 Jun 14;288(24):17884-94
pubmed: 23632025
Biochemistry. 2012 Jul 31;51(30):5894-902
pubmed: 22775458
Acta Crystallogr D Struct Biol. 2017 Feb 1;73(Pt 2):148-157
pubmed: 28177311
Biochim Biophys Acta. 2013 Jan;1834(1):98-111
pubmed: 22940581
DNA Repair (Amst). 2017 Oct;58:52-61
pubmed: 28866241
Acta Crystallogr D Biol Crystallogr. 2004 Dec;60(Pt 12 Pt 1):2126-32
pubmed: 15572765
Biochimie. 2012 Jun;94(6):1398-411
pubmed: 22484394
Acta Crystallogr D Biol Crystallogr. 2010 Feb;66(Pt 2):125-32
pubmed: 20124692
J Biol Chem. 2010 Jul 9;285(28):21487-95
pubmed: 20444688
Mol Neurodegener. 2009 Jul 23;4:33
pubmed: 19627603
Biochem Pharmacol. 2000 Nov 15;60(10):1497-504
pubmed: 11020452
Acta Crystallogr Sect F Struct Biol Cryst Commun. 2005 Oct 1;61(Pt 10):942-4
pubmed: 16511202
J Biol Chem. 2011 Jan 21;286(3):1987-98
pubmed: 21084296
Nucleic Acids Res. 2010 Jul;38(Web Server issue):W555-62
pubmed: 20478824
J Biol Chem. 2010 Dec 10;285(50):39249-59
pubmed: 20926390
J Appl Crystallogr. 2007 Aug 1;40(Pt 4):658-674
pubmed: 19461840
J Biol Chem. 2003 Dec 5;278(49):48786-93
pubmed: 14514675
Nat Struct Biol. 2003 Jan;10(1):19-25
pubmed: 12483204
Biochem Biophys Res Commun. 1967 Apr 20;27(2):157-62
pubmed: 6035483
Acta Crystallogr D Biol Crystallogr. 2007 Apr;63(Pt 4):550-4
pubmed: 17372361