Diagnostic biologique des angioedèmes bradykiniques : les recommandations du CREAK.
Algorithms
Angioedema
/ chemically induced
Angioedemas, Hereditary
/ classification
Angiotensin-Converting Enzyme Inhibitors
/ adverse effects
Bradykinin
/ metabolism
Child
Comorbidity
Complement C1 Inhibitor Protein
/ analysis
Early Diagnosis
Factor XII
/ physiology
Female
Fibrinolysin
/ physiology
Hematologic Diseases
/ epidemiology
Hereditary Angioedema Types I and II
/ diagnosis
Humans
Kallikreins
/ physiology
Lupus Erythematosus, Systemic
/ epidemiology
Pregnancy
Pregnancy Complications
/ blood
Symptom Assessment
Journal
Presse medicale (Paris, France : 1983)
ISSN: 2213-0276
Titre abrégé: Presse Med
Pays: France
ID NLM: 8302490
Informations de publication
Date de publication:
Jan 2019
Jan 2019
Historique:
received:
29
03
2018
revised:
01
06
2018
accepted:
25
06
2018
pubmed:
13
11
2018
medline:
27
2
2019
entrez:
13
11
2018
Statut:
ppublish
Résumé
Bradykinin mediated angioedema (BK-AE) can be associated either with C1Inhibitor deficiency (hereditary and acquired forms), either with normal C1Inh (hereditary form and drug induced AE as angiotensin converting enzyme inhibitors…). In case of high clinical suspicion of BK-AE, C1Inh exploration must be done at first: C1Inh function and antigenemy as well as C4 concentration. C1Inh deficiency is significant if the tests are below 50 % of the normal values and controlled a second time. In case of C1Inh deficiency, you have to identify hereditary from acquired forms. C1q and anti-C1Inh antibody tests are useful for acquired BK-AE. SERPING1 gene screening must be done if a hereditary angioedema is suspected, even if there is no family context (de novo mutation 15 %). If a hereditary BK-AE with normal C1Inh is suspected, F12 and PLG gene screening is suitable.
Identifiants
pubmed: 30416009
pii: S0755-4982(18)30325-7
doi: 10.1016/j.lpm.2018.06.015
pii:
doi:
Substances chimiques
Angiotensin-Converting Enzyme Inhibitors
0
Complement C1 Inhibitor Protein
0
SERPING1 protein, human
0
Factor XII
9001-30-3
Kallikreins
EC 3.4.21.-
Fibrinolysin
EC 3.4.21.7
Bradykinin
S8TIM42R2W
Types de publication
Journal Article
Practice Guideline
Langues
fre
Sous-ensembles de citation
IM
Pagination
55-62Informations de copyright
Copyright © 2018. Published by Elsevier Masson SAS.