Impact of polymorphisms in DNA repair genes XPD, hOGG1 and XRCC4 on colorectal cancer risk in a Chinese Han Population.
Adult
Aged
Alleles
Asian People
Case-Control Studies
Colorectal Neoplasms
/ diagnosis
DNA Glycosylases
/ genetics
DNA-Binding Proteins
/ genetics
Female
Gene Expression
Gene Frequency
Genotype
Heterozygote
Homozygote
Humans
Male
Middle Aged
Odds Ratio
Polymorphism, Single Nucleotide
Risk
Smoking
/ genetics
Xeroderma Pigmentosum Group D Protein
/ genetics
Colorectal cancer
DNA repair genes
gene polymorphism
Journal
Bioscience reports
ISSN: 1573-4935
Titre abrégé: Biosci Rep
Pays: England
ID NLM: 8102797
Informations de publication
Date de publication:
31 01 2019
31 01 2019
Historique:
received:
03
07
2018
revised:
16
10
2018
accepted:
01
11
2018
pubmed:
16
11
2018
medline:
30
7
2019
entrez:
16
11
2018
Statut:
epublish
Résumé
This research aimed to study the associations between XPD (G751A, rs13181), hOGG1 (C326G, rs1052133) and XRCC4 (G1394T, rs6869366) gene polymorphisms and the risk of colorectal cancer (CRC) in a Chinese Han population. A total of 225 Chinese Han patients with CRC were selected as the study group, and 200 healthy subjects were recruited as the control group. The polymorphisms of XPD G751A, hOGG1 C326G and XRCC4 G1394T loci were detected by the RFLP-PCR technique in the peripheral blood of all subjects. Compared with individuals carrying the XPD751 GG allele, the A allele carriers (GA/AA) had a significantly increased risk of CRC (adjusted OR = 2.109, 95%CI = 1.352-3.287, Our results suggest that XPD G751A, hOGG1 C326G and XRCC4 G1394T gene polymorphisms might play an important role in colorectal carcinogenesis and increase the risk of developing CRC in the Chinese Han population. The interaction between smoking and these gene polymorphisms would increase the risk of CRC.
Sections du résumé
BACKGROUND
This research aimed to study the associations between XPD (G751A, rs13181), hOGG1 (C326G, rs1052133) and XRCC4 (G1394T, rs6869366) gene polymorphisms and the risk of colorectal cancer (CRC) in a Chinese Han population.
METHOD
A total of 225 Chinese Han patients with CRC were selected as the study group, and 200 healthy subjects were recruited as the control group. The polymorphisms of XPD G751A, hOGG1 C326G and XRCC4 G1394T loci were detected by the RFLP-PCR technique in the peripheral blood of all subjects.
RESULTS
Compared with individuals carrying the XPD751 GG allele, the A allele carriers (GA/AA) had a significantly increased risk of CRC (adjusted OR = 2.109, 95%CI = 1.352-3.287,
CONCLUSION
Our results suggest that XPD G751A, hOGG1 C326G and XRCC4 G1394T gene polymorphisms might play an important role in colorectal carcinogenesis and increase the risk of developing CRC in the Chinese Han population. The interaction between smoking and these gene polymorphisms would increase the risk of CRC.
Identifiants
pubmed: 30429230
pii: BSR20181074
doi: 10.1042/BSR20181074
pmc: PMC6331672
pii:
doi:
Substances chimiques
DNA-Binding Proteins
0
XRCC4 protein, human
0
DNA Glycosylases
EC 3.2.2.-
oxoguanine glycosylase 1, human
EC 3.2.2.-
Xeroderma Pigmentosum Group D Protein
EC 3.6.4.12
ERCC2 protein, human
EC 5.99.-
Types de publication
Journal Article
Langues
eng
Informations de copyright
© 2019 The Author(s).
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