RNA Sequencing of the

Adult Aged Biomarkers / analysis Case-Control Studies Cytokines / blood DNA, Viral Female Herpesvirus 6, Human / genetics High-Throughput Nucleotide Sequencing / methods Humans Lymphoma, Large B-Cell, Diffuse / genetics Male Middle Aged Roseolovirus Infections / diagnosis Transcriptome Viral Proteins / genetics Viremia / diagnosis Virus Activation Virus Latency
HHV-6 RNA sequencing RNA-seq bone marrow transplantation diagnose diagnostics gene sequencing herpes human herpesviruses transcription transcriptome transplant transplant infectious diseases

Journal

Journal of virology
ISSN: 1098-5514
Titre abrégé: J Virol
Pays: United States
ID NLM: 0113724

Informations de publication

Date de publication:
01 02 2019
Historique:
received: 20 08 2018
accepted: 01 11 2018
pubmed: 16 11 2018
medline: 9 11 2019
entrez: 16 11 2018
Statut: epublish

Résumé

Human herpesvirus 6B (HHV-6B) DNA is frequently detected in human samples. Diagnostic assays distinguishing HHV-6B reactivation from latency are limited. This has impaired strategies to diagnose and treat HHV-6B-associated diseases. We used RNA sequencing to characterize and compare the HHV-6B transcriptome in multiple sample types, including (i) whole blood from hematopoietic cell transplant (HCT) recipients with and without HHV-6B plasma viremia, (ii) tumor tissue samples from subjects with large B cell lymphoma infected with HHV-6B, (iii) lymphoblastoid cell lines (LCLs) from subjects with inherited chromosomally integrated HHV-6B or latent infection with HHV-6B, and (iv) HHV-6B Z29 infected SupT1 CD4

Identifiants

DOI: 10.1128/JVI.01419-18 PMID: 30429336 PMC: PMC6340040
pubmed: 30429336
pii: JVI.01419-18
doi: 10.1128/JVI.01419-18
pmc: PMC6340040
pii:
doi:

Substances chimiques

Biomarkers 0
Cytokines 0
DNA, Viral 0
Viral Proteins 0

Types de publication

Journal Article Research Support, N.I.H., Extramural Research Support, Non-U.S. Gov't

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIAID NIH HHS
ID : K23 AI119133
Pays : United States
Organisme : NHLBI NIH HHS
ID : K99 HL088021
Pays : United States
Organisme : NHLBI NIH HHS
ID : R00 HL088021
Pays : United States
Organisme : NHLBI NIH HHS
ID : K24 HL093294
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA015704
Pays : United States
Organisme : NHLBI NIH HHS
ID : P01 HL122173
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA018029
Pays : United States
Organisme : NCI NIH HHS
ID : P01 CA078902
Pays : United States
Organisme : NHLBI NIH HHS
ID : P50 HL110787
Pays : United States

Informations de copyright

Copyright © 2019 American Society for Microbiology.

Références

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Auteurs

Joshua A Hill (JA)

Department of Medicine, University of Washington, Seattle, Washington, USA jahill3@fredhutch.org.
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
ORCID: 0000-0002-7665-7100

Minako Ikoma (M)

Seattle Children's Research Institute, Seattle, Washington, USA.

Danielle M Zerr (DM)

Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.
Seattle Children's Research Institute, Seattle, Washington, USA.

Ryan S Basom (RS)

Genomics and Bioinformatics Shared Resource, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Vikas Peddu (V)

Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

Meei-Li Huang (ML)

Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

Ruth Hall Sedlak (R)

Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

Keith R Jerome (KR)

Department of Laboratory Medicine, University of Washington, Seattle, Washington, USA.

Michael Boeckh (M)

Department of Medicine, University of Washington, Seattle, Washington, USA.
Vaccine and Infectious Disease Division, Fred Hutchinson Cancer Research Center, Seattle, Washington, USA.

Serge Barcy (S)

Seattle Children's Research Institute, Seattle, Washington, USA.

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Classifications MeSH

questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › RNA Sequencing of the
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Sujet âgé › RNA Sequencing of the
questionsmedicales.fr › Facteurs biologiques › Marqueurs biologiques › RNA Sequencing of the
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Caractéristiques des études épidémiologiques › Études épidémiologiques › Études cas-témoins › RNA Sequencing of the
questionsmedicales.fr › Facteurs biologiques › Protéines et peptides de signalisation intercellulaire › Cytokines › RNA Sequencing of the
questionsmedicales.fr › Acides nucléiques, nucléotides et nucléosides › Acides nucléiques › ADN › ADN viral › RNA Sequencing of the
questionsmedicales.fr › Virus › Virus à ADN › Herpesviridae › Betaherpesvirinae › Roseolovirus › Herpèsvirus humain de type 6 › RNA Sequencing of the
questionsmedicales.fr › Techniques d'investigation › Techniques génétiques › Analyse de séquence › Séquençage nucléotidique à haut débit › RNA Sequencing of the
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › RNA Sequencing of the
questionsmedicales.fr › Maladies du système immunitaire › Syndromes immunoprolifératifs › Syndromes lymphoprolifératifs › Lymphomes › Lymphome malin non hodgkinien › Lymphome B › Lymphome B diffus à grandes cellules › RNA Sequencing of the
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Adulte d'âge moyen › RNA Sequencing of the
questionsmedicales.fr › Infection › Maladies virales › Infections à virus à ADN › Infections à Herpesviridae › Infections à roséolovirus › RNA Sequencing of the
questionsmedicales.fr › Phénomènes génétiques › Structures génétiques › Transcriptome › RNA Sequencing of the
questionsmedicales.fr › Acides aminés, peptides et protéines › Protéines › Protéines virales › RNA Sequencing of the
questionsmedicales.fr › États, signes et symptômes pathologiques › Processus pathologiques › Inflammation › Sepsie › Virémie › RNA Sequencing of the
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Réplication virale › Activation virale › RNA Sequencing of the
questionsmedicales.fr › Phénomènes microbiologiques › Phénomènes physiologiques viraux › Latence virale › RNA Sequencing of the