The use of steroids to reduce complications after tonsillectomy: a systematic review and meta-analysis of randomized controlled studies.
Bleed
Meta-analysis
Nausea
Pain
Steroids
Tonsillectomy
Journal
European archives of oto-rhino-laryngology : official journal of the European Federation of Oto-Rhino-Laryngological Societies (EUFOS) : affiliated with the German Society for Oto-Rhino-Laryngology - Head and Neck Surgery
ISSN: 1434-4726
Titre abrégé: Eur Arch Otorhinolaryngol
Pays: Germany
ID NLM: 9002937
Informations de publication
Date de publication:
Feb 2019
Feb 2019
Historique:
received:
29
10
2018
accepted:
08
11
2018
pubmed:
19
11
2018
medline:
11
4
2019
entrez:
19
11
2018
Statut:
ppublish
Résumé
To systemically review and compare the efficacy of intravenous, local, and oral steroids in decreasing post-tonsillectomy pain, nausea, and vomiting, and its risk of causing hemorrhage. We searched electronic databases (PubMed, Scopus, Cochrane Library) and additional sources. The date of the most recent search was June 20th, 2018. We selected RCTs of steroids in all routes of administration, in all age groups who underwent tonsillectomy or adenotonsillectomy and studied the results of nausea/vomiting, pain, and hemorrhage. Data analysis was done using Review Manager 5.3.5 software. We included 64 studies (6,327 participants) with variety quality assessed by the Cochrane Handbook for Systematic Reviews of Interventions. IV steroids statistically and clinically significant decrease post-tonsillectomy nausea/vomiting in children and adult, with superior effect to local steroids (Children: OR 0.21; 95% CI 0.15-0.30; P < 0.001, I Intravenous steroids statistically significantly decrease post-tonsillectomy nausea/vomiting, and immediate pain scores (< 24 h) in children and adults. There is evidence in only children that local steroids statistically significantly decreases post-tonsillectomy nausea/vomiting, and pain scores during the 0-h to 1-day period.
Identifiants
pubmed: 30448929
doi: 10.1007/s00405-018-5202-2
pii: 10.1007/s00405-018-5202-2
doi:
Substances chimiques
Glucocorticoids
0
Types de publication
Journal Article
Meta-Analysis
Systematic Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
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