Cesarean Section Induces Microbiota-Regulated Immune Disturbances in C57BL/6 Mice.
Animals
CD11c Antigen
/ metabolism
Cesarean Section
/ adverse effects
Diet
Forkhead Transcription Factors
/ metabolism
Gastrointestinal Microbiome
/ immunology
Humans
Inflammation
/ diet therapy
Interleukin-4
/ metabolism
Intestinal Mucosa
/ immunology
Macrophages
/ immunology
Mice
Mice, Inbred C57BL
Models, Animal
Natural Killer T-Cells
/ immunology
Prebiotics
/ administration & dosage
Risk
T-Lymphocytes, Regulatory
/ immunology
Journal
Journal of immunology (Baltimore, Md. : 1950)
ISSN: 1550-6606
Titre abrégé: J Immunol
Pays: United States
ID NLM: 2985117R
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
received:
14
05
2018
accepted:
23
10
2018
pubmed:
30
11
2018
medline:
5
11
2019
entrez:
30
11
2018
Statut:
ppublish
Résumé
Epidemiological studies have shown that children born by cesarean section (CS) are at higher risk of developing chronic inflammatory diseases, and it has been suggested that a skewed gut microbial colonization process early in life and altered priming of the immune system are causative. The aim of this study was to clarify whether impaired regulatory immunity in CS-delivered C57BL/6 mice is dependent on gut microbiota (GM) disturbances. The GM of conventionally bred mice born by CS differed clearly from mice born by vaginal delivery. The proportion of regulatory T cells was reduced in mice born by CS, whereas the invariant NKT (iNKT) cell subset was increased compared with vaginal delivery mice. In addition, regulatory markers (
Identifiants
pubmed: 30487172
pii: jimmunol.1800666
doi: 10.4049/jimmunol.1800666
doi:
Substances chimiques
CD11c Antigen
0
Forkhead Transcription Factors
0
Foxp3 protein, mouse
0
Prebiotics
0
Interleukin-4
207137-56-2
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
142-150Informations de copyright
Copyright © 2018 by The American Association of Immunologists, Inc.