Expression of CD44, EGFR, p16, and their mutual combinations in patients with head and neck cancer: Impact on outcomes of intensity-modulated radiation therapy.
Adult
Aged
Cohort Studies
Disease-Free Survival
ErbB Receptors
/ genetics
Female
Gene Expression Regulation, Neoplastic
Genes, p16
Head and Neck Neoplasms
/ genetics
Humans
Hyaluronan Receptors
/ genetics
Kaplan-Meier Estimate
Male
Middle Aged
Multivariate Analysis
Prognosis
Proportional Hazards Models
Radiotherapy, Intensity-Modulated
/ methods
Retrospective Studies
Risk Assessment
Squamous Cell Carcinoma of Head and Neck
/ genetics
Survival Analysis
Treatment Outcome
CD44
EGFR
P16
immunohistochemistry
intensity-modulated radiotherapy
Journal
Head & neck
ISSN: 1097-0347
Titre abrégé: Head Neck
Pays: United States
ID NLM: 8902541
Informations de publication
Date de publication:
04 2019
04 2019
Historique:
received:
03
11
2017
revised:
18
07
2018
accepted:
28
09
2018
pubmed:
16
12
2018
medline:
10
10
2020
entrez:
16
12
2018
Statut:
ppublish
Résumé
Progress in radiation treatment of head and neck squamous cell carcinoma (HNSCC) deserves the studies focused on molecular predictors that would help to enhance individually tailored treatment. p16/epidermal growth factor receptor (EGFR)/cluster of differentiation-44 (CD44) was immunohistochemically analyzed in 165 HNSCC patients. In the entire group and the p16 negative cohort, better 3-year overall survival and locoregional control correlated with p16 positivity, CD44, and EGFR negativity were observed. Combined analysis revealed the worst results in the CD44+/p16-, EGFR+/p16-, and EGFR+/CD44+ groups and in the EGFR+/CD44+ within p16 negative cohort. Multivariate analysis found tumor stage, Karnofsky index, p16, and CD44 as prognostic factors of overall survival and clinical stage, and p16 as a prognostic factor for locoregional control. Clinical stage and Karnofsky index affected overall survival and tumor stage. EGFR affected locoregional control in the p16 negative subgroup. Our study confirmed the negative effect of CD44 and EGFR and the positive effect of p16 on radiotherapy results.
Sections du résumé
BACKGROUND
Progress in radiation treatment of head and neck squamous cell carcinoma (HNSCC) deserves the studies focused on molecular predictors that would help to enhance individually tailored treatment.
METHODS
p16/epidermal growth factor receptor (EGFR)/cluster of differentiation-44 (CD44) was immunohistochemically analyzed in 165 HNSCC patients.
RESULTS
In the entire group and the p16 negative cohort, better 3-year overall survival and locoregional control correlated with p16 positivity, CD44, and EGFR negativity were observed. Combined analysis revealed the worst results in the CD44+/p16-, EGFR+/p16-, and EGFR+/CD44+ groups and in the EGFR+/CD44+ within p16 negative cohort. Multivariate analysis found tumor stage, Karnofsky index, p16, and CD44 as prognostic factors of overall survival and clinical stage, and p16 as a prognostic factor for locoregional control. Clinical stage and Karnofsky index affected overall survival and tumor stage. EGFR affected locoregional control in the p16 negative subgroup.
CONCLUSION
Our study confirmed the negative effect of CD44 and EGFR and the positive effect of p16 on radiotherapy results.
Substances chimiques
CD44 protein, human
0
Hyaluronan Receptors
0
EGFR protein, human
EC 2.7.10.1
ErbB Receptors
EC 2.7.10.1
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
940-949Subventions
Organisme : Ministry of Health of the Czech Republic, by the Czech Health Research Council project, No. 15-31627A
Pays : International
Informations de copyright
© 2018 Wiley Periodicals, Inc.