TOWARDS THE USE OF NANODOSIMETRY TO PREDICT CELL SURVIVAL.
Journal
Radiation protection dosimetry
ISSN: 1742-3406
Titre abrégé: Radiat Prot Dosimetry
Pays: England
ID NLM: 8109958
Informations de publication
Date de publication:
01 May 2019
01 May 2019
Historique:
received:
21
11
2018
accepted:
21
11
2018
pubmed:
20
12
2018
medline:
5
6
2019
entrez:
20
12
2018
Statut:
ppublish
Résumé
Experimental nanodosimetry aims to develop a new concept of radiation quality, based on the correlation between initial features of particle tracks and late biological outcome. A direct proportionality has been observed between the cumulative probability of measuring at least k ionisations within a nanometric volume and inactivation cross sections at specific survival levels. Based on this proportionality, physical quantities which are measurable at the nanometre level can be used to estimate the alpha and beta parameters of the linear-quadratic dose-response model, provided that two proportionality factors are determined in a reference radiation field. This work describes the procedure and first results applied to published data for V79 cell survival after irradiation with protons and carbon ions.
Identifiants
pubmed: 30566675
pii: 5253225
doi: 10.1093/rpd/ncy274
doi:
Substances chimiques
Ions
0
Protons
0
Carbon
7440-44-0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
192-196Informations de copyright
© The Author(s) 2018. Published by Oxford University Press. All rights reserved. For Permissions, please email: journals.permissions@oup.com.