Metabolic heterogeneity underlies reciprocal fates of T
Animals
Autoimmune Diseases
/ immunology
Cell Transdifferentiation
Disease Models, Animal
Female
Immunologic Memory
/ immunology
Inflammation
/ immunology
Male
Mechanistic Target of Rapamycin Complex 1
/ metabolism
Mice
Regulatory-Associated Protein of mTOR
/ deficiency
Sequence Analysis, RNA
Signal Transduction
Single-Cell Analysis
Stem Cells
/ cytology
T Cell Transcription Factor 1
/ biosynthesis
T-Box Domain Proteins
/ biosynthesis
Th17 Cells
/ cytology
Tumor Necrosis Factor Receptor Superfamily, Member 7
/ metabolism
Journal
Nature
ISSN: 1476-4687
Titre abrégé: Nature
Pays: England
ID NLM: 0410462
Informations de publication
Date de publication:
01 2019
01 2019
Historique:
received:
30
11
2017
accepted:
30
10
2018
pubmed:
21
12
2018
medline:
30
6
2019
entrez:
21
12
2018
Statut:
ppublish
Résumé
A defining feature of adaptive immunity is the development of long-lived memory T cells to curtail infection. Recent studies have identified a unique stem-like T-cell subset amongst exhausted CD8-positive T cells in chronic infection
Identifiants
pubmed: 30568299
doi: 10.1038/s41586-018-0806-7
pii: 10.1038/s41586-018-0806-7
pmc: PMC6420879
mid: NIHMS1511275
doi:
Substances chimiques
Regulatory-Associated Protein of mTOR
0
T Cell Transcription Factor 1
0
T-Box Domain Proteins
0
T-box transcription factor TBX21
0
Tumor Necrosis Factor Receptor Superfamily, Member 7
0
Mechanistic Target of Rapamycin Complex 1
EC 2.7.11.1
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Pagination
101-105Subventions
Organisme : NIAID NIH HHS
ID : R01 AI131703
Pays : United States
Organisme : NCI NIH HHS
ID : P30 CA021765
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA176624
Pays : United States
Organisme : NCI NIH HHS
ID : R01 CA221290
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI101407
Pays : United States
Organisme : NINDS NIH HHS
ID : R01 NS064599
Pays : United States
Organisme : NIAID NIH HHS
ID : R37 AI105887
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI140761
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI105887
Pays : United States
Commentaires et corrections
Type : CommentIn
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