Oxytocin inhibits methamphetamine-associated learning and memory alterations by regulating DNA methylation at the Synaptophysin promoter.
Amphetamine-Related Disorders
/ metabolism
Animals
Central Nervous System Stimulants
/ pharmacology
DNA Methylation
/ drug effects
Disease Models, Animal
Learning
/ drug effects
Male
Memory
/ drug effects
Methamphetamine
/ pharmacology
Mice
Mice, Inbred C57BL
Oxytocics
/ pharmacology
Oxytocin
/ pharmacology
Promoter Regions, Genetic
/ drug effects
Synaptophysin
/ genetics
DNA methylation
DNA methyltransferase
methamphetamine
methyl CpG binding protein 2
oxytocin
synaptophysin
Journal
Addiction biology
ISSN: 1369-1600
Titre abrégé: Addict Biol
Pays: United States
ID NLM: 9604935
Informations de publication
Date de publication:
01 2020
01 2020
Historique:
received:
14
08
2018
revised:
26
09
2018
accepted:
17
10
2018
pubmed:
27
12
2018
medline:
11
2
2021
entrez:
27
12
2018
Statut:
ppublish
Résumé
Methamphetamine (METH) causes memory changes, but the underlying mechanisms are poorly understood. Epigenetic mechanisms, including DNA methylation, can potentially cause synaptic changes in the brain. Oxytocin (OT) plays a central role in learning and memory, but little is known of the impact of OT on METH-associated memory changes. Here, we explored the role of OT in METH-induced epigenetic alterations that underlie spatial and cognitive memory changes. METH (2.0 mg/kg, i.p.) was administered to male C57BL/6 mice once every other day for 8 days. OT (2.5 μg, i.c.v.) or aCSF was given prior to METH. Spatial and cognitive memory were assessed. In Hip and PFC, synaptic structures and proteins were examined, levels of DNA methyltransferases (DNMTs) and methyl CpG binding protein 2 (MECP2) were determined, and the DNA methylation status at the Synaptophysin (Syn) promoter was assessed. METH enhanced spatial memory, decreased synapse length, downregulated DNMT1, DNMT3A, DNMT3B, and MECP2, and induced DNA hypomethylation at the Syn promoter in Hip. In contrast, METH reduced cognitive memory, increased synapse thickness, upregulated DNMT1, DNMT3A, and MECP2, and induced DNA hypermethylation at the Syn promoter in PFC. OT pretreatment specifically ameliorated METH-induced learning and memory alterations, normalized synapse structures, and regulated DNMTs and MECP2 to reverse the DNA methylation status changes at the Syn promoter in Hip and PFC. DNA methylation is an important gene regulatory mechanism underlying METH-induced learning and memory alterations. OT can potentially be used to specifically manipulate METH-related memory changes.
Substances chimiques
Central Nervous System Stimulants
0
Oxytocics
0
SYP protein, human
0
Synaptophysin
0
Methamphetamine
44RAL3456C
Oxytocin
50-56-6
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
e12697Subventions
Organisme : National Key Scientific Project
Pays : International
Informations de copyright
© 2018 Society for the Study of Addiction.
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