A deletion in the Ctns gene causes renal tubular dysfunction and cystine accumulation in LEA/Tohm rats.
Alleles
Amino Acid Sequence
Amino Acid Transport Systems, Neutral
/ genetics
Animals
Biomarkers
Cystine
/ metabolism
DNA Mutational Analysis
Fibroblasts
/ drug effects
Genetic Linkage
Genotype
Kidney Tubules
/ metabolism
Mutation
Phenotype
Quantitative Trait Loci
Rats
Rats, Transgenic
Sequence Deletion
Journal
Mammalian genome : official journal of the International Mammalian Genome Society
ISSN: 1432-1777
Titre abrégé: Mamm Genome
Pays: United States
ID NLM: 9100916
Informations de publication
Date de publication:
02 2019
02 2019
Historique:
received:
04
11
2018
accepted:
19
12
2018
pubmed:
29
12
2018
medline:
28
7
2019
entrez:
29
12
2018
Statut:
ppublish
Résumé
The Long-Evans Agouti (LEA/Tohm) rat has recently been established as a new rat model of type 2 diabetes. The onset of diabetes mellitus was observed only in male LEA/Tohm rats; however, urinary glucose appeared before the onset of diabetes. To clarify the genetic basis of urinary glucose, we performed genetic linkage analysis using (BN × LEA) F
Identifiants
pubmed: 30591971
doi: 10.1007/s00335-018-9790-3
pii: 10.1007/s00335-018-9790-3
pmc: PMC6397714
doi:
Substances chimiques
Amino Acid Transport Systems, Neutral
0
Biomarkers
0
Cystine
48TCX9A1VT
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
23-33Références
Hum Mol Genet. 1999 Dec;8(13):2507-14
pubmed: 10556299
Genome Res. 2000 Feb;10(2):165-73
pubmed: 10673275
Exp Anim. 2001 Apr;50(2):147-51
pubmed: 11381618
EMBO J. 2001 Nov 1;20(21):5940-9
pubmed: 11689434
N Engl J Med. 2002 Jul 11;347(2):111-21
pubmed: 12110740
Biochem Biophys Res Commun. 2003 Apr 25;304(1):196-206
pubmed: 12705906
Rapid Commun Mass Spectrom. 2003;17(12):1297-311
pubmed: 12811753
Hum Mol Genet. 2004 Jul 1;13(13):1361-71
pubmed: 15128704
Chem Pharm Bull (Tokyo). 2007 Apr;55(4):503-10
pubmed: 17409537
Clin Biochem. 2007 Jun;40(9-10):692-8
pubmed: 17459360
Ann Intern Med. 2007 Aug 21;147(4):242-50
pubmed: 17709758
Amino Acids. 2009 Jul;37(2):367-75
pubmed: 18716858
Blood. 2009 Sep 17;114(12):2542-52
pubmed: 19506297
Nephrol Dial Transplant. 2010 Apr;25(4):1059-66
pubmed: 19846395
J Am Soc Nephrol. 2010 Feb;21(2):272-83
pubmed: 19959713
Mol Genet Metab. 2010 Apr;99(4):384-8
pubmed: 20061170
Mod Rheumatol. 2011 Jun;21(3):251-7
pubmed: 21188453
Kidney Int. 2011 Jun;79(11):1198-206
pubmed: 21248718
Kidney Int. 2012 Jan;81(2):179-89
pubmed: 21900880
Kidney Int. 2012 Jan;81(2):127-9
pubmed: 22205430
Transplant Proc. 2012 Jan;44(1):80-2
pubmed: 22310585
PLoS One. 2012;7(8):e42840
pubmed: 22912749
Clin Biochem. 2013 Feb;46(3):271-4
pubmed: 23078879
Drug Discov Today. 2013 Aug;18(15-16):785-92
pubmed: 23416144
J Diabetes Res. 2013;2013:986462
pubmed: 23691528
J Am Soc Nephrol. 2014 Jun;25(6):1163-9
pubmed: 24525029
ScientificWorldJournal. 2015;2015:309410
pubmed: 25866837
Endocrinology. 2016 Apr;157(4):1363-71
pubmed: 26812160
Orphanet J Rare Dis. 2016 Apr 22;11:47
pubmed: 27102039
BMC Nephrol. 2017 Sep 26;18(1):300
pubmed: 28950840
J Diabetes Investig. 2019 Mar;10(2):227-237
pubmed: 29987871
BMJ. 1988 Oct 29;297(6656):1086-91
pubmed: 3143437
Adv Pediatr. 1986;33:95-126
pubmed: 3541536
Nature. 1973 Aug 17;244(5416):458-9
pubmed: 4582506
Biochem Biophys Res Commun. 1994 Jul 15;202(1):512-8
pubmed: 8037756
Alcohol Alcohol Suppl. 1994;29(1):39-43
pubmed: 9063817
Nat Genet. 1997 Nov;17(3):280-4
pubmed: 9354790
Nat Genet. 1998 Apr;18(4):319-24
pubmed: 9537412
Bioinformatics. 1998;14(4):378-9
pubmed: 9632836
BMJ. 1998 Sep 12;317(7160):703-13
pubmed: 9732337