Nucleus accumbens neurochemistry in human anxiety: A 7 T
Adult
Anxiety
/ diagnostic imaging
Aspartic Acid
/ analogs & derivatives
Correlation of Data
Female
Glutamic Acid
/ metabolism
Glutamine
/ metabolism
Humans
Hydrocortisone
/ metabolism
Male
Neurochemistry
Nucleus Accumbens
/ diagnostic imaging
Personality
Proton Magnetic Resonance Spectroscopy
Psychiatric Status Rating Scales
Psychometrics
Saliva
/ chemistry
Taurine
/ metabolism
Tritium
/ metabolism
Young Adult
gamma-Aminobutyric Acid
/ metabolism
Anxiety
GABA
Nucleus accumbens
Personality
Stress
Taurine
Journal
European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology
ISSN: 1873-7862
Titre abrégé: Eur Neuropsychopharmacol
Pays: Netherlands
ID NLM: 9111390
Informations de publication
Date de publication:
03 2019
03 2019
Historique:
received:
16
10
2018
revised:
18
12
2018
accepted:
20
12
2018
pubmed:
3
1
2019
medline:
27
8
2019
entrez:
3
1
2019
Statut:
ppublish
Résumé
Individual differences in anxiety provide a differential predisposition to develop neuropsychiatric disorders. The neurochemical underpinnings of anxiety remain elusive, particularly in deep structures, such as the nucleus accumbens (NAc) whose involvement in anxiety is being increasingly recognized. We examined the associations between the neurochemical profile of human NAc metabolites involved in neural excitation and inhibition and inter-individual variation in temperamental and situational anxiety. Twenty-seven healthy 20-30 years-old human males were phenotyped with questionnaires for state and trait anxiety (State-Trait Anxiety Inventory, STAI), social anxiety (Liebowitz Social Anxiety Scale), negative mood (Beck Depression Inventory, BDI) and fatigue (Mental and Physical State Energy and Fatigue Scales, SEF). Using proton magnetic resonance spectroscopy (
Identifiants
pubmed: 30600114
pii: S0924-977X(18)32006-6
doi: 10.1016/j.euroneuro.2018.12.015
pii:
doi:
Substances chimiques
Glutamine
0RH81L854J
Tritium
10028-17-8
Taurine
1EQV5MLY3D
Aspartic Acid
30KYC7MIAI
Glutamic Acid
3KX376GY7L
gamma-Aminobutyric Acid
56-12-2
N-acetylaspartate
997-55-7
Hydrocortisone
WI4X0X7BPJ
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Pagination
365-375Informations de copyright
Copyright © 2018. Published by Elsevier B.V.