Helix-loop-helix proteins and the advent of cellular diversity: 30 years of discovery.
E proteins
HLH
Id proteins
hematopoiesis
myogenesis
neurogenesis
phylogeny
programming differentiation
somitogenesis
structure
Journal
Genes & development
ISSN: 1549-5477
Titre abrégé: Genes Dev
Pays: United States
ID NLM: 8711660
Informations de publication
Date de publication:
01 01 2019
01 01 2019
Historique:
entrez:
4
1
2019
pubmed:
4
1
2019
medline:
23
1
2019
Statut:
ppublish
Résumé
Helix-loop-helix (HLH) proteins are dimeric transcription factors that control lineage- and developmental-specific gene programs. Genes encoding for HLH proteins arose in unicellular organisms >600 million years ago and then duplicated and diversified from ancestral genes across the metazoan and plant kingdoms to establish multicellularity. Hundreds of HLH proteins have been identified with diverse functions in a wide variety of cell types. HLH proteins orchestrate lineage specification, commitment, self-renewal, proliferation, differentiation, and homing. HLH proteins also regulate circadian clocks, protect against hypoxic stress, promote antigen receptor locus assembly, and program transdifferentiation. HLH proteins deposit or erase epigenetic marks, activate noncoding transcription, and sequester chromatin remodelers across the chromatin landscape to dictate enhancer-promoter communication and somatic recombination. Here the evolution of HLH genes, the structures of HLH domains, and the elaborate activities of HLH proteins in multicellular life are discussed.
Identifiants
pubmed: 30602438
pii: 33/1-2/6
doi: 10.1101/gad.320663.118
pmc: PMC6317319
doi:
Substances chimiques
Basic Helix-Loop-Helix Transcription Factors
0
Types de publication
Journal Article
Research Support, N.I.H., Extramural
Review
Langues
eng
Sous-ensembles de citation
IM
Pagination
6-25Subventions
Organisme : NIAID NIH HHS
ID : P01 AI102853
Pays : United States
Organisme : NIAID NIH HHS
ID : R01 AI082850
Pays : United States
Organisme : Intramural NIH HHS
ID : Z01 AI000880
Pays : United States
Informations de copyright
© 2019 Murre; Published by Cold Spring Harbor Laboratory Press.
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