Omega-3 Fatty Acid Supplementation, Pro-Resolving Mediators, and Clinical Outcomes in Maternal-Infant Pairs.

Adjuvants, Immunologic Adult Anti-Inflammatory Agents Diet Records Dietary Supplements Docosahexaenoic Acids / administration & dosage Fatty Acids, Omega-3 / administration & dosage Female Fetal Blood / chemistry Humans Infant, Newborn Intensive Care, Neonatal Male Pregnancy Pregnancy Outcome Pregnancy, High-Risk Prenatal Care Surveys and Questionnaires
docosahexaenoic acid (DHA) fetal health omega-3 fatty acid pregnancy resolvins specialized pro-resolving lipid mediator (SPM)

Journal

Nutrients
ISSN: 2072-6643
Titre abrégé: Nutrients
Pays: Switzerland
ID NLM: 101521595

Informations de publication

Date de publication:
05 Jan 2019
Historique:
received: 05 12 2018
revised: 21 12 2018
accepted: 03 01 2019
entrez: 10 1 2019
pubmed: 10 1 2019
medline: 12 2 2019
Statut: epublish

Résumé

Omega (n)-3 fatty acids are vital to neonatal maturation, and recent investigations reveal n-3 fatty acids serve as substrates for the biosynthesis of specialized pro-resolving lipid mediators (SPM) that have anti-inflammatory and immune-stimulating effects. The role SPM play in the protection against negative maternal-fetal health outcomes is unclear, and there are no current biomarkers of n-3 fatty acid sufficiency. We sought to ascertain the relationships between n-3 fatty acid intake, SPM levels, and maternal-fetal health outcomes. We obtained n-3 fatty acid intake information from 136 mothers admitted for delivery using a food frequency questionnaire and measured docosahexaenoic acid (DHA)-derived SPMs resolvin D1 (RvD1) and RvD2 in maternal and cord plasma. We found significantly elevated SPM in maternal versus cord plasma, and increased SPM levels were associated with at-risk outcomes. We also identified that increased DHA intake was associated with elevated maternal plasma RvD1 (

Identifiants

DOI: 10.3390/nu11010098 PMID: 30621269 PMC: PMC6356980
pubmed: 30621269
pii: nu11010098
doi: 10.3390/nu11010098
pmc: PMC6356980
pii:
doi:

Substances chimiques

Adjuvants, Immunologic 0
Anti-Inflammatory Agents 0
Fatty Acids, Omega-3 0
resolvin D1 0
resolvin D2 0
Docosahexaenoic Acids 25167-62-8

Types de publication

Journal Article

Langues

eng

Sous-ensembles de citation

IM

Subventions

Organisme : NIEHS NIH HHS
ID : R00 ES025819
Pays : United States
Organisme : National Institute of Environmental Health Sciences
ID : K99ES025819
Organisme : National Institute of Environmental Health Sciences
ID : R00ES025819
Organisme : University of Nebraska Foundation
ID : Edna Ittner Pediatric Research Support Fund

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Auteurs

Tara M Nordgren (TM)

Division of Biomedical Sciences, School of Medicine, University of California, Riverside, CA 92521, USA. tmnordgren@gmail.com.
Pulmonary, Critical Care, Sleep & Allergy Division, Department of Internal Medicine, University of Nebraska Medical Center, Omaha, NE 68198-5910, USA. tmnordgren@gmail.com.

Ann Anderson Berry (A)

Department of Pediatrics, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-1205, USA. alanders@unmc.edu.

Matthew Van Ormer (M)

Department of Pediatrics, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-1205, USA. matthew.vanormer@unmc.edu.
ORCID: 0000-0002-1541-0155

Samuel Zoucha (S)

Department of Pediatrics, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-1205, USA. samuel_b_zoucha@rush.edu.

Elizabeth Elliott (E)

Department of Pediatrics, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-1205, USA. eelliott@childrensnational.org.

Rebecca Johnson (R)

Department of Pediatrics, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-1205, USA. Rebecca.johnson@unmc.edu.

Elizabeth McGinn (E)

Department of Pediatrics, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-1205, USA. elizabeth.mcginn@unmc.edu.

Caleb Cave (C)

Department of Pediatrics, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-1205, USA. caleb.cave@unmc.edu.
ORCID: 0000-0003-4829-6122

Katherine Rilett (K)

Department of Pediatrics, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-1205, USA. katherine.rilett@unmc.edu.

Kara Weishaar (K)

Department of Pediatrics, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-1205, USA. Kara.weishaar@unmc.edu.

Sai Sujana Maddipati (SS)

Department of Pediatrics, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-1205, USA. sujanamaddipati@creighton.edu.

Harriet Appeah (H)

Department of Pediatrics, College of Medicine, University of Nebraska Medical Center, Omaha, NE 68198-1205, USA. harriet.appeah@unmc.edu.

Corrine Hanson (C)

Medical Nutrition Education Division, College of Allied Health Professions, University of Nebraska Medical Center, Omaha, NE 68198-4045, USA. ckhanson@unmc.edu.

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Classifications MeSH

questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Effets physiologiques des médicaments › Facteurs immunologiques › Adjuvants immunologiques › Omega-3 Fatty Acid Supplementation,...
questionsmedicales.fr › Personnes › Tranches d'âge › Adulte › Omega-3 Fatty Acid Supplementation,...
questionsmedicales.fr › Actions chimiques et utilisations › Actions pharmacologiques › Utilisations thérapeutiques › Anti-inflammatoires › Omega-3 Fatty Acid Supplementation,...
questionsmedicales.fr › Administration des services de santé › Organisation et administration › Journaux alimentaires › Omega-3 Fatty Acid Supplementation,...
questionsmedicales.fr › Aliments et boissons › Aliments › Compléments alimentaires › Omega-3 Fatty Acid Supplementation,...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Acide docosahexaénoïque › Omega-3 Fatty Acid Supplementation,...
questionsmedicales.fr › Lipides › Huiles › Huiles de poisson › Acides gras omega-3 › Omega-3 Fatty Acid Supplementation,...
questionsmedicales.fr › Structures de l'embryon › Foetus › Sang foetal › Omega-3 Fatty Acid Supplementation,...
questionsmedicales.fr › Eucaryotes › Animaux › Chordés › Vertébrés › Mammifères › Eutheria › Primates › Haplorhini › Catarrhini › Hominidae › Humains › Omega-3 Fatty Acid Supplementation,...
questionsmedicales.fr › Personnes › Tranches d'âge › Nourrisson › Nouveau-né › Omega-3 Fatty Acid Supplementation,...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Soins de réanimation › Soins intensifs néonatals › Omega-3 Fatty Acid Supplementation,...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Omega-3 Fatty Acid Supplementation,...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Issue de la grossesse › Omega-3 Fatty Acid Supplementation,...
questionsmedicales.fr › Phénomènes physiologiques des appareils urinaire et reproducteur › Phénomènes physiologiques de la reproduction › Reproduction › Grossesse › Grossesse à haut risque › Omega-3 Fatty Acid Supplementation,...
questionsmedicales.fr › Établissements, main d'oeuvre et services de soins de santé › Services de santé › Soins aux patients › Prise en charge prénatale › Omega-3 Fatty Acid Supplementation,...
questionsmedicales.fr › Environnement et santé publique › Santé publique › Méthodes épidémiologiques › Collecte de données › Enquêtes et questionnaires › Omega-3 Fatty Acid Supplementation,...