Peptoids advance multidisciplinary research and undergraduate education in parallel: Sequence effects on conformation and lipid interactions.
chemistry education
fluorescence spectroscopy
peptidomimetics
phospholipid membranes
sequence-structure relationships
Journal
Biopolymers
ISSN: 1097-0282
Titre abrégé: Biopolymers
Pays: United States
ID NLM: 0372525
Informations de publication
Date de publication:
Apr 2019
Apr 2019
Historique:
received:
29
09
2018
revised:
17
12
2018
accepted:
21
12
2018
pubmed:
12
1
2019
medline:
14
8
2019
entrez:
12
1
2019
Statut:
ppublish
Résumé
Peptoids are versatile peptidomimetic molecules with wide-ranging applications from drug discovery to materials science. An understanding of peptoid sequence features that contribute to both their three-dimensional structures and their interactions with lipids will expand functions of peptoids in varied fields. Furthermore, these topics capture the enthusiasm of undergraduate students who prepare and study diverse peptoids in laboratory coursework and/or in faculty led research. Here, we present the synthesis and study of 21 peptoids with varied functionality, including 19 tripeptoids and 2 longer oligomers. We observed differences in fluorescence spectral features for 10 of the tripeptoids that correlated with peptoid flexibility and relative positioning of chromophores. Interactions of representative peptoids with sonicated glycerophospholipid vesicles were also evaluated using fluorescence spectroscopy. We observed evidence of conformational changes effected by lipids for select peptoids. We also summarize our experiences engaging students in peptoid-based projects to advance both research and undergraduate educational objectives in parallel.
Identifiants
pubmed: 30633339
doi: 10.1002/bip.23256
pmc: PMC6590334
doi:
Substances chimiques
Glycerophospholipids
0
Peptoids
0
Types de publication
Journal Article
Langues
eng
Pagination
e23256Subventions
Organisme : Bastiani Research Award
Organisme : Carl Gellert and Celia Berta Gellert Foundation
Organisme : Research Corporation for Scientific Advancement
ID : Cottrell Scholar Award
Organisme : Henry Luce Foundation, Clare Boothe Luce Professorship and Clare Boothe Luce Undergraduate Research Fellowship
Organisme : Santa Clara University
Organisme : National Science Foundation
ID : CHE-1566604
Informations de copyright
© 2019 The Authors. Biopolymers published by Wiley Periodicals, Inc.
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