Crosstalk between Ras and inositol phosphate signaling revealed by lithium action on inositol monophosphatase in Schizophyllum commune.
IMPA
Inositol monophosphatase
Inositol phosphates
Ras
Schizophyllum commune
Signaling
basidiomycete fungi
lithium
Journal
Advances in biological regulation
ISSN: 2212-4934
Titre abrégé: Adv Biol Regul
Pays: England
ID NLM: 101572336
Informations de publication
Date de publication:
05 2019
05 2019
Historique:
received:
12
12
2018
revised:
31
12
2018
accepted:
02
01
2019
pubmed:
15
1
2019
medline:
16
4
2020
entrez:
15
1
2019
Statut:
ppublish
Résumé
Mushroom forming basidiomycete Schizophyllum commune has been used as a tractable model organism to study fungal sexual development. Ras signaling activation via G-protein-coupled receptors (GPCRs) has been postulated to play a significant role in the mating and development of S. commune. In this study, a crosstalk between Ras signaling and inositol phosphate signaling by inositol monophosphatase (IMPase) is revealed. Constitutively active Ras1 leads to the repression of IMPase transcription and lithium action on IMPase activity is compensated by the induction of IMPase at transcriptome level. Astonishingly, in S. commune lithium induces a considerable shift to inositol phosphate metabolism leading to a massive increase in the level of higher phosphorylated inositol species up to the inositol pyrophosphates. The lithium induced metabolic changes are not observable in a constitutively active Ras1 mutant. In addition to that, proteome profile helps us to elucidate an overview of lithium action to the broad aspect of fungal metabolism and cellular signaling. Taken together, these findings imply a crosstalk between Ras and inositol phosphate signaling.
Identifiants
pubmed: 30639095
pii: S2212-4926(18)30170-2
doi: 10.1016/j.jbior.2019.01.001
pmc: PMC6520614
pii:
doi:
Substances chimiques
Fungal Proteins
0
Inositol Phosphates
0
Lithium
9FN79X2M3F
Phosphoric Monoester Hydrolases
EC 3.1.3.2
myo-inositol-1 (or 4)-monophosphatase
EC 3.1.3.25
Types de publication
Journal Article
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
78-88Subventions
Organisme : Medical Research Council
ID : MC_U122680443
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_00012/4
Pays : United Kingdom
Organisme : Medical Research Council
ID : MC_UU_12018/4
Pays : United Kingdom
Informations de copyright
Copyright © 2019. Published by Elsevier Ltd.
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