Atopic Dermatitis Is an IL-13-Dominant Disease with Greater Molecular Heterogeneity Compared to Psoriasis.
Cohort Studies
Dermatitis, Atopic
/ genetics
Gene Expression Profiling
Humans
Interleukin-13
/ genetics
Interleukin-4
/ metabolism
Organ Specificity
/ genetics
Psoriasis
/ genetics
RNA
/ genetics
RNA, Long Noncoding
/ genetics
Sequence Analysis, RNA
Signal Transduction
Skin
/ metabolism
Th2 Cells
/ immunology
Transcriptome
Journal
The Journal of investigative dermatology
ISSN: 1523-1747
Titre abrégé: J Invest Dermatol
Pays: United States
ID NLM: 0426720
Informations de publication
Date de publication:
07 2019
07 2019
Historique:
received:
04
06
2018
revised:
29
11
2018
accepted:
05
12
2018
pubmed:
15
1
2019
medline:
28
5
2020
entrez:
15
1
2019
Statut:
ppublish
Résumé
Atopic dermatitis (AD) affects up to 20% of children and adults worldwide. To gain a deeper understanding of the pathophysiology of AD, we conducted a large-scale transcriptomic study of AD with deeply sequenced RNA-sequencing samples using long (126-bp) paired-end reads. In addition to the comparisons against previous transcriptomic studies, we conducted in-depth analysis to obtain a high-resolution view of the global architecture of the AD transcriptome and contrasted it with that of psoriasis from the same cohort. By using 147 RNA samples in total, we found striking correlation between dysregulated genes in lesional psoriasis and lesional AD skin with 81% of AD dysregulated genes being shared with psoriasis. However, we described disease-specific molecular and cellular features, with AD skin showing dominance of IL-13 pathways, but with near undetectable IL-4 expression. We also demonstrated greater disease heterogeneity and larger proportion of dysregulated long noncoding RNAs in AD, and illustrated the translational impact, including skin-type classification and drug-target prediction. This study is by far the largest study comparing the AD and psoriasis transcriptomes using RNA sequencing and demonstrating the shared inflammatory components, as well as specific discordant cytokine signatures of these two skin diseases.
Identifiants
pubmed: 30641038
pii: S0022-202X(19)30007-7
doi: 10.1016/j.jid.2018.12.018
pmc: PMC6711380
mid: NIHMS1044514
pii:
doi:
Substances chimiques
Interleukin-13
0
RNA, Long Noncoding
0
Interleukin-4
207137-56-2
RNA
63231-63-0
Types de publication
Comparative Study
Journal Article
Research Support, N.I.H., Extramural
Research Support, Non-U.S. Gov't
Langues
eng
Sous-ensembles de citation
IM
Pagination
1480-1489Subventions
Organisme : NIAMS NIH HHS
ID : P30 AR057216
Pays : United States
Organisme : NIAMS NIH HHS
ID : K08 AR060802
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR042742
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR054966
Pays : United States
Organisme : NIAMS NIH HHS
ID : K01 AR072773
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR069071
Pays : United States
Organisme : NIAMS NIH HHS
ID : P30 AR075043
Pays : United States
Organisme : NIAMS NIH HHS
ID : K01 AR072129
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR065183
Pays : United States
Organisme : NIAMS NIH HHS
ID : R01 AR063611
Pays : United States
Informations de copyright
Copyright © 2019 The Authors. Published by Elsevier Inc. All rights reserved.
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