TNF-α Inhibitors Decrease Classical CD14
Adult
Arthritis, Rheumatoid
/ drug therapy
Blood Cell Count
CD11b Antigen
/ metabolism
CD11c Antigen
/ metabolism
Female
GPI-Linked Proteins
/ metabolism
Humans
Immunosuppressive Agents
/ administration & dosage
Lipopolysaccharide Receptors
/ metabolism
Male
Middle Aged
Monocytes
/ drug effects
Receptors, IgG
/ metabolism
Spondylitis, Ankylosing
/ drug therapy
Treatment Outcome
Tumor Necrosis Factor-alpha
/ antagonists & inhibitors
ankylosing spondylitis
disease activity
monocytes
rheumatoid arthritis
tumor necrosis factor inhibitor
Journal
International journal of molecular sciences
ISSN: 1422-0067
Titre abrégé: Int J Mol Sci
Pays: Switzerland
ID NLM: 101092791
Informations de publication
Date de publication:
12 Jan 2019
12 Jan 2019
Historique:
received:
17
12
2018
revised:
04
01
2019
accepted:
04
01
2019
entrez:
16
1
2019
pubmed:
16
1
2019
medline:
27
4
2019
Statut:
epublish
Résumé
Monocytes are pivotal cells in inflammatory joint diseases. We aimed to determine the effect of TNF-α inhibitors (TNFi) on peripheral blood monocyte subpopulations and their activation in ankylosing spondylitis (AS) and rheumatoid arthritis (RA) patients with high disease activity. To address this, we studied 50 (32 AS, 18 RA) patients with highly active disease with no prior history of TNFi use who were recruited and assigned to TNFi or placebo treatment for 12 weeks. Cytometric and clinical assessment was determined at baseline, four, and 12 weeks after initiation of TNFi treatment. We observed that treatment with TNFi led to a significant decrease in CD14
Identifiants
pubmed: 30642076
pii: ijms20020291
doi: 10.3390/ijms20020291
pmc: PMC6358965
pii:
doi:
Substances chimiques
CD11b Antigen
0
CD11c Antigen
0
FCGR3B protein, human
0
GPI-Linked Proteins
0
ITGAM protein, human
0
Immunosuppressive Agents
0
Lipopolysaccharide Receptors
0
Receptors, IgG
0
Tumor Necrosis Factor-alpha
0
Types de publication
Journal Article
Langues
eng
Sous-ensembles de citation
IM
Subventions
Organisme : Ministerstwo Nauki i Szkolnictwa Wyższego
ID : 1280/MOB/IV/2015/0
Organisme : Ministerstwo Nauki i Szkolnictwa Wyższego
ID : 1300/1/MOB/IV/2015/0
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